Plasma Biomarkers and Incident CKD Among Individuals Without Diabetes
Le D, Chen J, Shlipak M, Ix J, Sarnak M, Gutierrez O, Schelling J, Bonventre J, Sabbisetti V, Schrauben S, Coca S, Kimmel P, Vasan R, Grams M, Parikh C, Coresh J, Rebholz C, Consortium C. Plasma Biomarkers and Incident CKD Among Individuals Without Diabetes. Kidney Medicine 2023, 5: 100719. PMID: 37841418, PMCID: PMC10568645, DOI: 10.1016/j.xkme.2023.100719.Peer-Reviewed Original ResearchSoluble urokinase plasminogen activator receptorKidney injury molecule-1Incident chronic kidney diseaseChronic kidney diseaseLevels of kidney injury molecule-1Development of kidney diseaseMonocyte chemoattractant protein-1Kidney diseaseTNFR-2TNFR-1Development of chronic kidney diseaseConcentrations of kidney injury molecule-1Odds of incident chronic kidney diseaseAssociated with incident chronic kidney diseaseTumor necrosis factor receptor 2Urokinase plasminogen activator receptorCases of incident CKDYears of follow-upTumor necrosis factor receptor 1AbstractText Label="PLAIN-LANGUAGE SUMMARYBaseline plasma biomarkersHuman cartilage glycoprotein-39Kidney disease progressionPlasminogen activator receptorChemoattractant protein-1Urinary Biomarkers of Kidney Tubule Health and Mortality in Persons with CKD and Diabetes Mellitus
Vasquez-Rios G, Katz R, Levitan E, Cushman M, Parikh C, Kimmel P, Bonventre J, Waikar S, Schrauben S, Greenberg J, Sarnak M, Ix J, Shlipak M, Gutierrez O. Urinary Biomarkers of Kidney Tubule Health and Mortality in Persons with CKD and Diabetes Mellitus. Kidney360 2023, 4: e1257-e1264. PMID: 37533144, PMCID: PMC10547219, DOI: 10.34067/kid.0000000000000226.Peer-Reviewed Original ResearchConceptsKidney injury molecule-1Monocyte chemoattractant protein-1Kidney tubule healthCause-specific mortalityUrine biomarkersYKL-40Risk factorsCardiovascular deathCause mortalityHigh riskChitinase-3-like protein 1Greater riskHigher MCP-1Higher urine levelsUrine KIM-1Injury molecule-1Cause-specific deathMortality risk factorsProportional hazards regressionRisk of deathAdditional risk factorsProtein 1Cancer-related deathChemoattractant protein-1Alpha-1-microglobulin