2022
Transient Receptor Potential Vanilloid 1 Function at Central Synapses in Health and Disease
Meza R, Ancatén-González C, Chiu C, Chávez A. Transient Receptor Potential Vanilloid 1 Function at Central Synapses in Health and Disease. Frontiers In Cellular Neuroscience 2022, 16: 864828. PMID: 35518644, PMCID: PMC9062234, DOI: 10.3389/fncel.2022.864828.Peer-Reviewed Original ResearchTransient receptor potential vanilloid 1Synaptic plasticityTRPV1 functionActivity-dependent synaptic changesLigand-gated nonselective cation channelCentral synapsesNonselective cation channelsRegulate synaptic functionVanilloid 1Pain sensationCation channelsHealth and DiseaseSynaptic efficacySynaptic changesBrain regionsPostsynaptic compartmentsNeurotransmitter releasePresynaptic terminalsTherapeutic treatmentSynaptic functionBrain disordersPotential roleSynapsesBrainPain
2020
Muscarinic Regulation of Spike Timing Dependent Synaptic Plasticity in the Hippocampus
Fuenzalida M, Chiu C, Chávez A. Muscarinic Regulation of Spike Timing Dependent Synaptic Plasticity in the Hippocampus. Neuroscience 2020, 456: 50-59. PMID: 32828940, DOI: 10.1016/j.neuroscience.2020.08.015.Peer-Reviewed Original ResearchConceptsSpike timing dependent synaptic plasticityTiming-dependent plasticityCellular basis of learningMagnitude of long-term changesMuscarinic receptorsInhibitory synapsesMuscarinic regulationSynaptic transmissionSynaptic plasticityShape learningCentral synapsesBasis of learningCellular basisNetwork activityBrain network activityLong-term changesAcetylcholineHippocampusLearningSynapsesSTDPBrainMuscarinicMemoryReceptors