2010
Endocannabinoid Mediated Long-Term Depression at Inhibitory Synapses
Chiu C, Castillo P. Endocannabinoid Mediated Long-Term Depression at Inhibitory Synapses. 2010, 149-166. DOI: 10.1007/978-1-4419-6978-1_11.Peer-Reviewed Original ResearchI-LTDLong-term potentiationSynaptic plasticityActivating presynaptic type 1 cannabinoid receptorsHeterosynaptic form of plasticityType 1 cannabinoid receptorInhibitory synapsesGABAergic synaptic plasticityMetabotropic glutamatergic receptorsExcitatory synaptic plasticityBasis of learningECB mobilizationFunction of neural circuitsCellular basis of learningBrain structuresExcitability of neuronsExcitatory glutamatergic synapsesGlutamatergic receptorsExcitatory/inhibitory balanceGABA releaseRetrograde messengerActivity-dependent changesNeural circuitsGABAergic synapsesGlutamatergic synapses
2007
Input-specific plasticity at excitatory synapses mediated by endocannabinoids in the dentate gyrus
Chiu C, Castillo P. Input-specific plasticity at excitatory synapses mediated by endocannabinoids in the dentate gyrus. Neuropharmacology 2007, 54: 68-78. PMID: 17706254, PMCID: PMC2225485, DOI: 10.1016/j.neuropharm.2007.06.026.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornArachidonic AcidsBenzoxazinesCalciumCalcium Channel BlockersCannabinoid Receptor ModulatorsCholinergic AgentsDentate GyrusElectric StimulationEndocannabinoidsExcitatory Postsynaptic PotentialsGlyceridesIn Vitro TechniquesMiceMice, Inbred C57BLMice, KnockoutMorpholinesNaphthalenesNeural PathwaysNeuronal PlasticityNeuronsPatch-Clamp TechniquesRatsRats, WistarReceptor, Cannabinoid, CB1ConceptsECB signalingDentate gyrusDiacyglycerol lipaseGroup I metabotropic glutamate receptorsDepress excitatory synaptic transmissionSuppression of excitationBreakdown of anandamideExcitatory synapsesMedial perforant pathAbundant eCBECB-LTDECB releaseCannabinoid receptorsExcitatory synaptic transmissionBrain structuresGlutamatergic inputsEntorhinal cortexSynaptic plasticityGlutamate receptorsPerforant pathDentate granule cellsDentateEndocannabinoidGyrusAnandamide