2023
Sleep dysfunction mediates the relationship between hypothalamic-insula connectivity and anxiety-depression symptom severity bidirectionally in young adults
Li G, Chen Y, Chaudhary S, Li C, Hao D, Yang L, Li C. Sleep dysfunction mediates the relationship between hypothalamic-insula connectivity and anxiety-depression symptom severity bidirectionally in young adults. NeuroImage 2023, 279: 120340. PMID: 37611815, DOI: 10.1016/j.neuroimage.2023.120340.Peer-Reviewed Original ResearchMeSH KeywordsAnxietyDepressionEmotionsFemaleHumansHypothalamusMaleSleepSleep Wake DisordersYoung AdultConceptsPittsburgh Sleep Quality IndexRight insulaSymptom severityMediation analysisSleep dysfunctionWhole-brain regressionHuman Connectome Project datasetSubjective mood stateYoung adultsState functional connectivityDepression symptom severityNegative emotionsCognitive performanceEmotional deficitsEmotional statesPotential sex differencesAffective functionsDrinking severityMood statesMotivated behaviorFunctional connectivityPoor sleep qualityRSFCSleep Quality IndexSleep quality
2022
Hypothalamic connectivities predict individual differences in ADT-elicited changes in working memory and quality of life in prostate cancer patients
Chaudhary S, Roy A, Summers C, Zhornitsky S, Ahles T, Li CR, Chao HH. Hypothalamic connectivities predict individual differences in ADT-elicited changes in working memory and quality of life in prostate cancer patients. Scientific Reports 2022, 12: 9567. PMID: 35688928, PMCID: PMC9187668, DOI: 10.1038/s41598-022-13361-4.Peer-Reviewed Original ResearchConceptsAndrogen deprivation therapyProstate cancer patientsQuality of lifeCancer patientsCorrect response rateMonths of ADTLong-term androgen deprivation therapyResponse rateNon-metastatic prostate cancerMontreal Cognitive Assessment scoreProspective observational studyState functional connectivityCognitive Assessment scoreDeprivation therapyHypothalamic connectivityAndrogen deprivationPrognostic markerProstate cancerGonadal axisObservational studyYears of educationQOL effectsControl groupQoLSalience networkThe effects of androgen deprivation on working memory and quality of life in prostate cancer patients: The roles of hypothalamic connectivity
Chaudhary S, Zhornitsky S, Roy A, Summers C, Ahles T, Li C, Chao HH. The effects of androgen deprivation on working memory and quality of life in prostate cancer patients: The roles of hypothalamic connectivity. Cancer Medicine 2022, 11: 3425-3436. PMID: 35315585, PMCID: PMC9487881, DOI: 10.1002/cam4.4704.Peer-Reviewed Original ResearchConceptsAndrogen deprivation therapyMid-cingulate cortexEffects of ADTFunctional connectivityPrecentral gyrusN-back taskN-back performanceState functional connectivityMontreal Cognitive Assessment scoreHypothalamic functional connectivityProspective observational studyNonmetastatic prostate cancerProstate cancer patientsCognitive Assessment scoreQuality of lifeSustain attentionAffective functionsDeprivation therapyHypothalamic connectivityYears of educationAndrogen deprivationCorrect response rateQOL scoresCancer patientsClinical correlates
2020
Resting state hypothalamic and dorsomedial prefrontal cortical connectivity of the periaqueductal gray in cocaine addiction
Zhang S, Zhornitsky S, Wang W, Le TM, Dhingra I, Chen Y, Li C. Resting state hypothalamic and dorsomedial prefrontal cortical connectivity of the periaqueductal gray in cocaine addiction. Addiction Biology 2020, 26: e12989. PMID: 33300238, PMCID: PMC8614224, DOI: 10.1111/adb.12989.Peer-Reviewed Original ResearchConceptsPeriaqueductal grayPain circuitsDrug useCocaine addictionFunctional connectivityPrefrontal cortical connectivityState functional connectivityReward circuit dysfunctionRecent cocaine useHealthy control participantsInferior parietal cortexCompulsive drug useHabitual drug useCircuit dysfunctionCocaine withdrawalCocaine-dependent individualsCocaine cravingCortical connectivitySignificant anxietyDorsomedial prefrontalParietal cortexCocaine useIntrinsic connectivitySubcortical hubsDrug seekingThe Neural Processes Interlinking Social Isolation, Social Support, and Problem Alcohol Use
Le TM, Wang W, Zhornitsky S, Dhingra I, Chen Y, Zhang S, Li CR. The Neural Processes Interlinking Social Isolation, Social Support, and Problem Alcohol Use. The International Journal Of Neuropsychopharmacology 2020, 24: 333-343. PMID: 33211853, PMCID: PMC8059487, DOI: 10.1093/ijnp/pyaa086.Peer-Reviewed Original ResearchConceptsSocial supportVentral striatumVS connectivityAlcohol misuseSocial isolationWhole-brain multiple regressionProblem drinkingProblem drinkersAlcohol useResting-state functional magnetic resonanceFunctional magnetic resonanceMiddle frontal gyrusPotential protective factorsProblem alcohol usePrefrontal cortical modulationCognitive controlIndividual differencesNeural processesNeural substratesFrontal gyrusPrefrontal connectivityElevated stress responseFunctional connectivityPath analysisNeural connectivity
2019
The interrelationship of body mass index with gray matter volume and resting-state functional connectivity of the hypothalamus
Le TM, Liao DL, Ide J, Zhang S, Zhornitsky S, Wang W, Li CR. The interrelationship of body mass index with gray matter volume and resting-state functional connectivity of the hypothalamus. International Journal Of Obesity 2019, 44: 1097-1107. PMID: 31796869, PMCID: PMC8643195, DOI: 10.1038/s41366-019-0496-8.Peer-Reviewed Original ResearchConceptsResting-state functional connectivityWhole-brain multiple regressionGray matter volumeInsula connectivityBody mass indexFunctional connectivitySeed-based resting-state functional connectivityMatter volumeSuperior parietal lobuleVoxel-based morphometry analysisMultiple regressionConclusionsThe current findingsBody weightCognitive controlMultiple brain circuitsBrain mechanismsIndividual differencesInhibitory controlParietal lobuleHypothalamic connectivityMass indexMediation analysisBrain circuitsHigher body mass indexCurrent findingsHypothalamic Responses to Cocaine and Food Cues in Individuals with Cocaine Dependence
Zhang S, Zhornitsky S, Le TM, Li CR. Hypothalamic Responses to Cocaine and Food Cues in Individuals with Cocaine Dependence. The International Journal Of Neuropsychopharmacology 2019, 22: 754-764. PMID: 31420667, PMCID: PMC6929672, DOI: 10.1093/ijnp/pyz044.Peer-Reviewed Original ResearchConceptsHealthy control participantsHypothalamic activationCocaine useCocaine-dependent participantsFood cuesCocaine addictionHypothalamic responseControl participantsCocaine Craving QuestionnaireRecent cocaine useFunctional magnetic resonance imagingMagnetic resonance imagingCue-related activationsInferior parietal cortexHypothalamic dysfunctionClinical variablesDopaminergic pathwaysTonic cravingFood intakeQuestionnaire scoresRodent studiesVisual cortexParietal cortexResonance imagingHypothalamus
2018
Hypothalamic response to cocaine cues and cocaine addiction severity
Zhang S, Zhornitsky S, Angarita GA, Li C. Hypothalamic response to cocaine cues and cocaine addiction severity. Addiction Biology 2018, 25: e12682. PMID: 30295396, PMCID: PMC6453736, DOI: 10.1111/adb.12682.Peer-Reviewed Original ResearchConceptsCocaine Craving QuestionnaireCocaine Selective Severity AssessmentFunctional magnetic resonance imagingCocaine-dependent individualsAddiction severityOrbitofrontal cortexHypothalamic responseVentral striatumCocaine addictionCocaine cuesAngular gyrusBilateral orbitofrontal cortexBilateral visual cortexCue-induced cravingMagnetic resonance imagingMiddle frontal gyrusClinical featuresNeutral cuesDopaminergic circuitsHypothalamusVisual cortexResonance imagingDopaminergic midbrainFrontal gyrusAg response
2016
Central nervous system regulation of eating: Insights from human brain imaging
Farr OM, Li CS, Mantzoros CS. Central nervous system regulation of eating: Insights from human brain imaging. Metabolism 2016, 65: 699-713. PMID: 27085777, PMCID: PMC4834455, DOI: 10.1016/j.metabol.2016.02.002.Peer-Reviewed Original ResearchConceptsCentral nervous systemCentral nervous system regulationOvereating/obesityBody weight regulationNervous system regulationWeight regulationNervous systemEnergy homeostasisObesity researchAvailable evidenceBrain imagingRespective underlying mechanismsAppetiteHomeostatic controlClinical researchersUnderlying mechanismHuman brain imagingSystem regulationHuman brainExact relative contributionObesityHumansHypothalamusPathogenesisCentral role