2020
Age-Related Structural and Functional Changes of the Hippocampus and the Relationship with Inhibitory Control
Hu S, Li CR. Age-Related Structural and Functional Changes of the Hippocampus and the Relationship with Inhibitory Control. Brain Sciences 2020, 10: 1013. PMID: 33352718, PMCID: PMC7766783, DOI: 10.3390/brainsci10121013.Peer-Reviewed Original ResearchStop-signal reaction timeGray matter volumeHippocampal gray matter volumePosterior hippocampusSequential effectsAge-related changesAnterior hippocampal activationTrial reaction timeStop-signal taskDistinct neural markersRight posterior hippocampusSignal reaction timeStop-signal probabilityRegional activityReaction timeAge-Related StructuralCognitive controlCognitive agingHippocampal activationProactive controlSignal taskBehavioral performanceAge-related reductionInhibitory controlHippocampal activity
2019
Neural correlates of enhanced response inhibition in the aftermath of stress
Chang J, Hu J, Li CR, Yu R. Neural correlates of enhanced response inhibition in the aftermath of stress. NeuroImage 2019, 204: 116212. PMID: 31546050, PMCID: PMC7509808, DOI: 10.1016/j.neuroimage.2019.116212.Peer-Reviewed Original ResearchConceptsInhibitory controlAcute stressMagnetic resonance imaging studySignal taskResonance imaging studyFunctional magnetic resonance imaging studyMiddle frontal gyrusTrier Social Stress TestControl conditionSignal reaction timeAftermath of stressSocial Stress TestImaging studiesCognitive functionDynamic causal modelingStress exposureEnhanced response inhibitionPilot studyFrontal gyrusLife stressNeural mechanismsStriatumResponse inhibitionNeural correlatesImmediate effectsImaging the effects of age on proactive control in healthy adults
Hu S, Job M, Jenks SK, Chao HH, Li CR. Imaging the effects of age on proactive control in healthy adults. Brain Imaging And Behavior 2019, 13: 1526-1537. PMID: 31011949, PMCID: PMC6812594, DOI: 10.1007/s11682-019-00103-w.Peer-Reviewed Original ResearchConceptsInferior occipital gyrusStop-signal reaction timePrefrontal cortexProactive controlProactive inhibitionOlder adultsReactive inhibitionSuperior parietal lobuleSequential effectsEffect of ageSignal reaction timeCaudate headDistinct neural processesParacentral lobuleTrial reaction timeVentromedial prefrontal cortexLateral prefrontal cortexHealthy adultsNeural changesNeural plasticityOccipital gyrusParietal lobuleReaction timeYoung adultsBelief Model
2018
Structural and functional cerebral bases of diminished inhibitory control during healthy aging
Hu S, Ide JS, Chao HH, Castagna B, Fischer KA, Zhang S, Li C. Structural and functional cerebral bases of diminished inhibitory control during healthy aging. Human Brain Mapping 2018, 39: 5085-5096. PMID: 30113124, PMCID: PMC6287913, DOI: 10.1002/hbm.24347.Peer-Reviewed Original ResearchConceptsProlonged stop signal reaction timeStop-signal reaction timeAge-related reductionInhibitory controlFunctional changesPrefrontal cortexAge-related diminutionSignal taskRight dorsolateral prefrontal cortexSame brain regionsFunctional magnetic resonance imagingMagnetic resonance imagingMedial prefrontal cortexInferior parietal cortexResponse inhibitionDorsolateral prefrontal cortexInferior frontal cortexDiminished inhibitory controlCerebral changesStructure-function associationsSignal reaction timeCaudate headAge-related differencesStop-signal taskFrontal cortexTime scale properties of task and resting-state functional connectivity: Detrended partial cross-correlation analysis
Ide JS, Li CR. Time scale properties of task and resting-state functional connectivity: Detrended partial cross-correlation analysis. NeuroImage 2018, 173: 240-248. PMID: 29454934, PMCID: PMC5911227, DOI: 10.1016/j.neuroimage.2018.02.029.Peer-Reviewed Original ResearchConceptsDefault mode networkResting-state functional connectivityPre-supplementary motor areaPrefrontal cortical structuresFunctional connectivity analysisFunctional connectivity measuresSignal reaction timeMotor areaBrain regionsBrain functionFunctional connectivityBarratt impulsivityCortical structuresInterest analysisLow-frequency fluctuationsMode networkBOLD signalSignal taskBrain networksConnectivity analysisConnectivity measuresFMRI dataRestPrevious studies
2016
The Right Superior Frontal Gyrus and Individual Variation in Proactive Control of Impulsive Response
Hu S, Ide JS, Zhang S, Li CR. The Right Superior Frontal Gyrus and Individual Variation in Proactive Control of Impulsive Response. Journal Of Neuroscience 2016, 36: 12688-12696. PMID: 27974616, PMCID: PMC5157110, DOI: 10.1523/jneurosci.1175-16.2016.Peer-Reviewed Original ResearchConceptsStop-signal reaction timeRight superior frontal gyrusSuperior frontal gyrusConflict anticipationProactive controlFrontal gyrusImpulsive responsesCognitive controlSignal taskInhibitory controlImpulse controlRegional activationEfficient response inhibitionReaction time differencesMotor urgencyVentromedial prefrontal cortexStop-signal taskYoung adultsSignal reaction timePosterior cingulate cortexIndividual variationError RTAction restraintNeural basisResponse inhibitionA dual but asymmetric role of the dorsal anterior cingulate cortex in response inhibition and switching from a non-salient to salient action
Manza P, Hu S, Chao HH, Zhang S, Leung HC, Li CS. A dual but asymmetric role of the dorsal anterior cingulate cortex in response inhibition and switching from a non-salient to salient action. NeuroImage 2016, 134: 466-474. PMID: 27126003, PMCID: PMC4912860, DOI: 10.1016/j.neuroimage.2016.04.055.Peer-Reviewed Original ResearchConceptsDorsal anterior cingulate cortexStop-signal reaction timeAnterior cingulate cortexSignal reaction timeCingulate cortexResponse inhibitionMotor inhibitionPre-supplementary motor areaRegional activationPre-SMA functionRegional brain activationMotor response inhibitionMotor areaStop trialsSalience processingBrain activationSalience detectionSuccess trialsSignal taskTrialsInhibitionSuccessful inhibitionInfrequent stimuliCortexActivationAssociation of Drinking Problems and Duration of Alcohol Use to Inhibitory Control in Nondependent Young Adult Social Drinkers
Hu S, Zhang S, Chao HH, Krystal JH, Li CS. Association of Drinking Problems and Duration of Alcohol Use to Inhibitory Control in Nondependent Young Adult Social Drinkers. Alcohol Clinical And Experimental Research 2016, 40: 319-328. PMID: 26833431, PMCID: PMC4742397, DOI: 10.1111/acer.12964.Peer-Reviewed Original ResearchConceptsAlcohol Use Disorders Identification TestYears of drinkingStop-signal reaction timeAlcohol useAge-related changesAlcohol misuseInhibitory controlAUDIT scoresDrinking problemsNondependent drinkersProlonged stop signal reaction timeChronic alcohol useAnterior cingulate cortexPresupplementary motor areaDisorders Identification TestRight inferior frontal gyrusResponse inhibitionSuperior temporal gyrusYoung adult social drinkersFunctional magnetic resonanceAdult social drinkersSignal reaction timeCerebral responsesInferior frontal gyrusHigher AUDIT
2015
Independent component analysis of functional networks for response inhibition: Inter‐subject variation in stop signal reaction time
Zhang S, Tsai S, Hu S, Xu J, Chao HH, Calhoun VD, Li C. Independent component analysis of functional networks for response inhibition: Inter‐subject variation in stop signal reaction time. Human Brain Mapping 2015, 36: 3289-3302. PMID: 26089095, PMCID: PMC4545723, DOI: 10.1002/hbm.22819.Peer-Reviewed Original ResearchConceptsStop-signal reaction timeStop-signal taskCognitive controlSignal reaction timeResponse inhibitionStop successBeta weightsReaction timeCritical executive functionFunctional networksIndependent component analysisExecutive functionError trialsSignal taskComponent processesMotor preparationBrain networksBehavioral validityMotor regionsRace modelLinear modelingGeneral linear modelingLarge sampleIndependent componentsFMRIConflict anticipation in alcohol dependence — A model-based fMRI study of stop signal task
Hu S, Ide JS, Zhang S, Sinha R, Li CS. Conflict anticipation in alcohol dependence — A model-based fMRI study of stop signal task. NeuroImage Clinical 2015, 8: 39-50. PMID: 26106526, PMCID: PMC4473266, DOI: 10.1016/j.nicl.2015.03.008.Peer-Reviewed Original ResearchConceptsStop-signal reaction timeHealthy control individualsConflict anticipationAlcohol dependenceCognitive controlProactive controlSignal taskSequential effectsModel-based fMRI studyAlcohol consumptionStop signalPre-supplementary motor areaBilateral inferior parietal cortexPerigenual anterior cingulate cortexSignificant sequential effectInferior parietal cortexSignal reaction timeWhole-brain responsesAnterior cingulate cortexRecent alcohol consumptionNeural correlatesFMRI studyNeural markersMotor areaTrial onset
2014
Cognitive Control in Opioid Dependence and Methadone Maintenance Treatment
Liao DL, Huang CY, Hu S, Fang SC, Wu CS, Chen WT, Lee TS, Chen PC, Li CS. Cognitive Control in Opioid Dependence and Methadone Maintenance Treatment. PLOS ONE 2014, 9: e94589. PMID: 24727743, PMCID: PMC3984179, DOI: 10.1371/journal.pone.0094589.Peer-Reviewed Original ResearchConceptsMethadone maintenance treatmentOpioid dependencePost-error slowingStop-signal reaction timePsychiatric comorbidityMaintenance treatmentCognitive controlAbstinence durationOpioid-dependent individualsResponse inhibitionHealthy control participantsMethadone treatmentSignal reaction timeCognitive dysfunctionMMT groupPsychiatric clinicSubstance misuseLonger abstinenceComorbiditiesHC participantsControl participantsDependent individualsSignal taskBehavioral adjustmentPublic health
2013
Neural bases of individual variation in decision time
Hu S, Tseng Y, Winkler AD, Li C. Neural bases of individual variation in decision time. Human Brain Mapping 2013, 35: 2531-2542. PMID: 24027122, PMCID: PMC4511156, DOI: 10.1002/hbm.22347.Peer-Reviewed Original ResearchConceptsStop-signal reaction timeSupplementary motor areaNeural basisSignal taskMovement timeTrial reaction timeStop-signal taskSignal reaction timeCaudate headReaction timeCognitive controlResponse inhibitionResponse selectionIndividual variationAccumulator modelBehavioral performanceComponent processesDecision timeLonger movement timesHuman behaviorMotor areaSimple taskBrain imagingSuccessful goTaskChanges in cerebral morphometry and amplitude of low-frequency fluctuations of BOLD signals during healthy aging: correlation with inhibitory control
Hu S, Chao H, Zhang S, Ide JS, Li CS. Changes in cerebral morphometry and amplitude of low-frequency fluctuations of BOLD signals during healthy aging: correlation with inhibitory control. Brain Structure And Function 2013, 219: 983-994. PMID: 23553547, PMCID: PMC3760988, DOI: 10.1007/s00429-013-0548-0.Peer-Reviewed Original ResearchConceptsDorsal lateral prefrontal cortexInferior parietal lobuleSupplementary motor areaFrontal regionsInhibitory controlCingulate cortexStop-signal reaction timeBilateral dorsal lateral prefrontal cortexGM volumeCognitive performance decreasesRight inferior parietal lobuleLow-frequency fluctuationsLateral prefrontal cortexSignal reaction timePosterior cingulate cortexAnterior cingulate cortexBlood oxygenation level-dependent (BOLD) signalLevel-dependent signalFamily-wise errorGray matter volumeRecent alcohol useCognitive challengesParietal lobuleSpontaneous neural activityVoxel-based morphometry
2012
Decreased saliency processing as a neural measure of Barratt impulsivity in healthy adults
Farr OM, Hu S, Zhang S, Li CS. Decreased saliency processing as a neural measure of Barratt impulsivity in healthy adults. NeuroImage 2012, 63: 1070-1077. PMID: 22885245, PMCID: PMC3472158, DOI: 10.1016/j.neuroimage.2012.07.049.Peer-Reviewed Original ResearchConceptsStop-signal reaction timeStop-signal taskMiddle frontal cortexCognitive controlTrait impulsivityResponse inhibitionComponent processesSaliency processingBarratt impulsivityCognitive control functionsLeft dorsolateral prefrontal cortexPost-error slowingRegional brain activationDorsolateral prefrontal cortexSignal reaction timeYoung adult participantsBarratt Impulsivity ScaleNeural measuresError processingSignal taskBrain activationPsychophysiological interactionImpulsivity scoresBIS-11Impulsivity Scale
2011
Neural processes of preparatory control for stop signal inhibition
Hu S, Li C. Neural processes of preparatory control for stop signal inhibition. Human Brain Mapping 2011, 33: 2785-2796. PMID: 21976392, PMCID: PMC3293936, DOI: 10.1002/hbm.21399.Peer-Reviewed Original ResearchConceptsStop-signal reaction timeFunctional magnetic resonance imagingMotor inhibitionShorter stop-signal reaction timesPrefrontal cortexRight orbital frontal cortexMotor executionPrimary motor cortexOrbital frontal cortexSignal inhibitionMagnetic resonance imagingPosterior cingulate cortexInferior parietal lobuleRight prefrontal cortexMotor cortexSignal reaction timeBilateral putamenFrontal cortexHealthy adultsVentromedial prefrontal cortexCingulate cortexResonance imagingPreparatory inhibitionParietal lobuleStop-signal trials
2010
Biological markers of the effects of intravenous methylphenidate on improving inhibitory control in cocaine-dependent patients
Li CS, Morgan PT, Matuskey D, Abdelghany O, Luo X, Chang JL, Rounsaville BJ, Ding YS, Malison RT. Biological markers of the effects of intravenous methylphenidate on improving inhibitory control in cocaine-dependent patients. Proceedings Of The National Academy Of Sciences Of The United States Of America 2010, 107: 14455-14459. PMID: 20660731, PMCID: PMC2922598, DOI: 10.1073/pnas.1002467107.Peer-Reviewed Original ResearchConceptsMiddle frontal cortexStop-signal reaction timeCocaine-dependent patientsWhole-brain linear regressionLonger stop-signal reaction timesFunctional MRI studyInhibitory controlInhibition-related activationBlood pressureIntravenous methylphenidatePeripheral biomarkersSignal reaction timeFrontal cortexStop-signal taskIndividualized treatmentHealthy individualsMRI studiesVentromedial prefrontal cortexSpecific neural mechanismsCocaine dependenceBiological markersPrefrontal cortexPatientsMethylphenidate responseSignal task
2009
Activation of the pre-supplementary motor area but not inferior prefrontal cortex in association with short stop signal reaction time – an intra-subject analysis
Chao H, Luo X, Chang J, Li CS. Activation of the pre-supplementary motor area but not inferior prefrontal cortex in association with short stop signal reaction time – an intra-subject analysis. BMC Neuroscience 2009, 10: 75. PMID: 19602259, PMCID: PMC2719646, DOI: 10.1186/1471-2202-10-75.Peer-Reviewed Original ResearchConceptsStop-signal reaction timeRight inferior prefrontal cortexStop-signal taskPre-supplementary motor areaShorter stop-signal reaction timesInferior prefrontal cortexSignal reaction timePrefrontal cortexResponse inhibitionMotor areaMiddle/posterior cingulate cortexMotor response inhibitionInferior frontal cortexRegional brain activationStop-signal inhibitionLonger stop-signal reaction timesInhibitory motor controlPosterior cingulate cortexMedial prefrontal cortexReaction timeGreater activityAttentional monitoringNeural processesSignal taskBrain activationAltered Impulse Control in Alcohol Dependence: Neural Measures of Stop Signal Performance
Li C, Luo X, Yan P, Bergquist K, Sinha R. Altered Impulse Control in Alcohol Dependence: Neural Measures of Stop Signal Performance. Alcohol Clinical And Experimental Research 2009, 33: 740-750. PMID: 19170662, PMCID: PMC2697053, DOI: 10.1111/j.1530-0277.2008.00891.x.Peer-Reviewed Original ResearchConceptsHealthy control subjectsFunctional magnetic resonance imagingAlcohol dependencePost-error behavioral adjustmentDorsolateral prefrontal cortexAlcohol urgesTrial reaction timePost-error slowingPrefrontal cortexLeft dorsolateral prefrontal cortexRight dorsolateral prefrontal cortexMagnetic resonance imagingImpulse controlStatistical parametric mappingStop errorAbstinent patientsControl subjectsNovel pharmacotherapiesSignal reaction timeTreatment outcomesFrontal cortexHC subjectsResonance imagingBehavioral adjustmentSubcortical structures
2008
Subcortical processes of motor response inhibition during a stop signal task
Li CS, Yan P, Sinha R, Lee TW. Subcortical processes of motor response inhibition during a stop signal task. NeuroImage 2008, 41: 1352-1363. PMID: 18485743, PMCID: PMC2474693, DOI: 10.1016/j.neuroimage.2008.04.023.Peer-Reviewed Original ResearchConceptsMotor response inhibitionSubthalamic nucleusStop-signal reaction timeStop-signal taskResponse inhibitionShorter stop-signal reaction timesSignal inhibitionMagnetic resonance imaging studyGreater activationLonger stop-signal reaction timesSignal taskResonance imaging studyFunctional magnetic resonance imaging studySubcortical processesStop-signal inhibitionGroups of subjectsSubthalamic activityBasal gangliaSignal reaction timeThalamic nucleiCaudate headImaging studiesStop trialsMedial prefrontal activityCortical mechanisms
2007
Neural Correlates of Impulse Control During Stop Signal Inhibition in Cocaine-Dependent Men
Li CS, Huang C, Yan P, Bhagwagar Z, Milivojevic V, Sinha R. Neural Correlates of Impulse Control During Stop Signal Inhibition in Cocaine-Dependent Men. Neuropsychopharmacology 2007, 33: 1798-1806. PMID: 17895916, PMCID: PMC2731999, DOI: 10.1038/sj.npp.1301568.Peer-Reviewed Original ResearchConceptsRostral anterior cingulate cortexCocaine-dependent menFunctional magnetic resonance imagingCocaine dependenceResponse inhibitionNeural correlatesHealthy control subjectsRisk of relapsePre-supplementary motor areaSubstance use disordersAnterior cingulate cortexImpulse controlSignal inhibitionMagnetic resonance imagingUseful neural markersStop-signal inhibitionRelative hypoactivationMale patientsControl subjectsSignal reaction timeMotor areaYears of educationUse disordersCingulate cortexResonance imaging