2024
Immunosenescence-related T cell phenotypes and white matter in schizophrenia patients with tardive dyskinesia
Li N, Li Y, Yu T, Gou M, Chen W, Wang X, Tong J, Chen S, Tan S, Wang Z, Tian B, Li C, Tan Y. Immunosenescence-related T cell phenotypes and white matter in schizophrenia patients with tardive dyskinesia. Schizophrenia Research 2024, 269: 36-47. PMID: 38723519, DOI: 10.1016/j.schres.2024.04.017.Peer-Reviewed Original ResearchCD95+ T cellsTardive dyskinesiaT-cell phenotypeT cell subpopulationsBrain structural abnormalitiesT cellsSchizophrenia patientsFractional anisotropyCD95+Distribution of T cell phenotypesStructural abnormalitiesAssociated with brain structural abnormalitiesMemory T-cell subpopulationsCD8+ T cellsLevels of IFN-gInferior fronto-occipital fasciculusLevels of cytokinesSuperior longitudinal fasciculusFronto-occipital fasciculusChoroid plexus volumeIntracellular levelsWhite matter tractsOrofacial TDPallidum volumesPublished routines
2023
Regional Homogeneity in schizophrenia patients with tardive dyskinesia: a resting-state fMRI study
Yu T, Li Y, Li N, Huang J, Fan F, Luo X, Tan S, Yang F, Tian B, Tian L, Li C, Tan Y. Regional Homogeneity in schizophrenia patients with tardive dyskinesia: a resting-state fMRI study. Psychiatry Research Neuroimaging 2023, 335: 111724. PMID: 37871408, DOI: 10.1016/j.pscychresns.2023.111724.Peer-Reviewed Original ResearchConceptsAbnormal Involuntary Movement ScaleTardive dyskinesiaInferior semilunar lobuleSchizophrenia patientsCourse of TDRegional homogeneityResting-state functional magnetic resonance imagingResting-state fMRI studySeverity of TDCerebral regional homogeneityUpper limb scoreNegative Syndrome ScaleNon-TD groupMedial frontal gyrusFunctional magnetic resonance imagingMagnetic resonance imagingLower ReHoReHo valuesHigher ReHoLimb scoreNeuronal degenerationHealthy controlsFunctional abnormalitiesMovement ScaleLeft supramarginal gyrus
2022
Dysfunctional monocytic toll-like receptor 4 signaling pathway and cognitive deficits in chronic schizophrenia patients with tardive dyskinesia
Li N, Li Y, Huang J, Zhang P, Tong J, Chen S, Cui Y, Tan S, Wang Z, Yang F, Hong E, Li CR, Tian L, Tan Y. Dysfunctional monocytic toll-like receptor 4 signaling pathway and cognitive deficits in chronic schizophrenia patients with tardive dyskinesia. Neuroscience Letters 2022, 777: 136581. PMID: 35337952, DOI: 10.1016/j.neulet.2022.136581.Peer-Reviewed Original ResearchConceptsToll-like receptor 4Abnormal Involuntary Movement ScaleTardive dyskinesiaChronic schizophrenia patientsSchizophrenia patientsMATRICS Consensus Cognitive BatteryReceptor 4TD patientsHigher toll-like receptor 4Cognitive deficitsSeverity of TDNegative Syndrome ScaleInnate immune systemNTD patientsTLR4 levelsHealthy controlsAIMS scoresMovement ScalePatientsConsensus Cognitive BatteryLPS stimulationTLR4 signalsPathway disturbancesLipopolysaccharide (LPS) stimulationSyndrome Scale
2021
N-methyl-D-aspartate receptor antibody and the choroid plexus in schizophrenia patients with tardive dyskinesia
Li N, Huang J, Zhang P, Tong J, Chen S, Cui Y, Tan S, Wang Z, Tian B, Li CR, Hong LE, Tian L, Tan Y. N-methyl-D-aspartate receptor antibody and the choroid plexus in schizophrenia patients with tardive dyskinesia. Journal Of Psychiatric Research 2021, 142: 290-298. PMID: 34411812, DOI: 10.1016/j.jpsychires.2021.08.010.Peer-Reviewed Original ResearchConceptsNMDAR antibody levelsNeuronal N-methyl-D-aspartate receptorAbnormal Involuntary Movement ScaleTardive dyskinesiaAntibody levelsCentral nervous systemChoroid plexusAIMS scoresN-methyl-D-aspartate receptor antibodiesSchizophrenia patientsN-methyl-D-aspartate receptorsOrofacial tardive dyskinesiaCP volumeNegative Syndrome ScaleEnzyme-linked immunosorbentNMDAR antibodiesAutoimmune abnormalitiesImmune disturbancesReceptor antibodiesHealthy controlsImmune barrierMovement ScaleNervous systemNTD groupSyndrome ScaleKynurenine metabolism and metabolic syndrome in patients with schizophrenia
Zhang P, Huang J, Gou M, Zhou Y, Tong J, Fan F, Cui Y, Luo X, Tan S, Wang Z, Yang F, Tian B, Li CR, Hong LE, Tan Y. Kynurenine metabolism and metabolic syndrome in patients with schizophrenia. Journal Of Psychiatric Research 2021, 139: 54-61. PMID: 34034146, DOI: 10.1016/j.jpsychires.2021.05.004.Peer-Reviewed Original ResearchConceptsMetabolic syndromeKP metabolitesMS scorePathogenesis of MSKynurenine pathway metabolismRegression analysisKynurenine metabolismPatient groupHealthy controlsMultiple linear regression analysisSchizophrenia patientsLinear regression analysisPathway metabolismPatientsContributory roleSchizophreniaHigh nicotinamide adenine dinucleotideNicotinamide adenine dinucleotideMS factorsPotential rolePartial correlation analysisScoresMultiple regression analysisSyndromePathogenesisEffects of microRNA-181b-5p on cognitive deficits in first-episode patients with schizophrenia: Mediated by BCL-2
Gou M, Pan S, Tong J, Zhou Y, Han J, Xie T, Yu T, Feng W, Li Y, Chen S, Cui Y, Tian B, Tan MDS, Wang Z, Luo X, Li CR, Zhang P, Huang J, Hong LE, Tan Y, Tian L. Effects of microRNA-181b-5p on cognitive deficits in first-episode patients with schizophrenia: Mediated by BCL-2. Journal Of Psychiatric Research 2021, 136: 358-365. PMID: 33636692, DOI: 10.1016/j.jpsychires.2021.02.003.Peer-Reviewed Original ResearchConceptsFirst-episode patientsBcl-2 mRNAEnzyme Linked Immunosorbent AssayMATRICS Consensus Cognitive BatteryQuantitative real-time PCRCognitive deficitsCognitive functionGender-matched healthy controlsBcl-2Pathogenesis of schizophreniaPeripheral whole bloodExpression levelsNegative Syndrome ScaleBcl-2 protein expressionLinked Immunosorbent AssayBcl-2 protein levelsPeripheral bloodHealthy controlsBcl-2 mRNA levelsReal-time PCRTarget genes Bcl-2Consensus Cognitive BatterySchizophrenia patientsSyndrome ScaleGene Bcl-2
2020
Functional disconnection between subsystems of the default mode network in schizophrenia
Fan F, Tan S, Huang J, Chen S, Fan H, Wang Z, Li CR, Tan Y. Functional disconnection between subsystems of the default mode network in schizophrenia. Psychological Medicine 2020, 52: 2270-2280. PMID: 33183375, DOI: 10.1017/s003329172000416x.Peer-Reviewed Original ResearchConceptsFirst-episode schizophreniaDysfunctional default mode networkDefault mode networkRecurrent schizophreniaIllness durationHealthy controlsSchizophrenia patientsConnectivity strengthResting-state functional connectivity analysisReduced connectivity strengthMode networkFunctional connectivity analysisClinical symptomsPatient groupConnectivity deficitsEarly diagnosisFunctional disconnectionIndependent cohortRES groupMTL dysfunctionPatientsDMN subsystemsFunctional connectivitySchizophreniaMTL subsystem
2018
Decreased Gray Matter Volume of Cuneus and Lingual Gyrus in Schizophrenia Patients with Tardive Dyskinesia is Associated with Abnormal Involuntary Movement
Yu T, Li Y, Fan F, Cao H, Luo X, Tan S, Yang F, Zhang X, Shugart YY, Hong LE, Li CR, Tan Y. Decreased Gray Matter Volume of Cuneus and Lingual Gyrus in Schizophrenia Patients with Tardive Dyskinesia is Associated with Abnormal Involuntary Movement. Scientific Reports 2018, 8: 12884. PMID: 30150749, PMCID: PMC6110787, DOI: 10.1038/s41598-018-31186-y.Peer-Reviewed Original ResearchConceptsGray matter volumeAbnormal Involuntary Movement ScaleTardive dyskinesiaMatter volumeTD severityAntipsychotic medication treatmentCerebral morphological changesAbnormal involuntary movementsBrain structural magnetic resonance imagesPsychopathological symptomsNegative Syndrome ScaleNon-TD groupVoxel-based morphometryMedication treatmentHealthy controlsGMV changesMotor disordersAIMS scoresInvoluntary movementsMovement ScaleStructural magnetic resonance imagesTemporal cortexSchizophrenia patientsLingual gyrusSyndrome Scale
2004
Do schizophrenia patients make more perseverative than non-perseverative errors on the Wisconsin Card Sorting Test? A meta-analytic study
Li CS. Do schizophrenia patients make more perseverative than non-perseverative errors on the Wisconsin Card Sorting Test? A meta-analytic study. Psychiatry Research 2004, 129: 179-190. PMID: 15590045, DOI: 10.1016/j.psychres.2004.06.016.Peer-Reviewed Original ResearchConceptsSchizophrenia patientsWisconsin Card Sorting TestNon-perseverative errorsCard Sorting TestStudy of patientsInhibitory functionSorting TestHealthy controlsPatientsPerseverative errorsHealthy participantsSchizophreniaExecutive functionMeta-analytic studyMarginal levelsComparable numberHigher number
2003
Auditory discrimination in female adolescents varying in schizotypal features: Preliminary findings
Li C, Yang Y, Chen M, Chen WJ, Liu J. Auditory discrimination in female adolescents varying in schizotypal features: Preliminary findings. Psychiatry And Clinical Neurosciences 2003, 57: 391-397. PMID: 12839520, DOI: 10.1046/j.1440-1819.2003.01137.x.Peer-Reviewed Original ResearchConceptsSchizotypal Personality QuestionnaireAuditory discriminationPerceptual Aberration ScaleResponse biasSchizotypal featuresSPQ scoresChinese Health QuestionnaireImpaired auditory processingHigher SPQ scoresSignal detection theoryFemale adolescent subjectsPreliminary findingsAuditory perceptionDiscrimination taskAuditory processingImpaired performanceAuditory detectionDetection theoryPersonality QuestionnaireFemale adolescentsAuditory hallucinationsPsychological statusSchizophrenia patientsYoung adultsGroups of subjects
2002
Impairment of temporal attention in patients with schizophrenia
Li CS, Lin WH, Yang YY, Huang CC, Chen TW, Chen YC. Impairment of temporal attention in patients with schizophrenia. Neuroreport 2002, 13: 1427-1430. PMID: 12167767, DOI: 10.1097/00001756-200208070-00016.Peer-Reviewed Original ResearchConceptsRapid serial visual presentation taskCore cognitive deficitVisual presentation taskEducation-matched control subjectsNumber of distractorsSignal detection theoryAttentional blinkT2 detectionTemporal attentionPresentation taskAttention impairmentVisual stimuliTemporal deploymentCognitive deficitsDetection theorySchizophrenia patientsSchizophrenia subjectsRapid successionSchizophreniaImpairmentTemporal gatingAttentionDistractorsBlinkStimuliImpaired detection of visual motion in schizophrenia patients
Li CS. Impaired detection of visual motion in schizophrenia patients. Progress In Neuro-Psychopharmacology And Biological Psychiatry 2002, 26: 929-934. PMID: 12369268, DOI: 10.1016/s0278-5846(02)00207-5.Peer-Reviewed Original ResearchConceptsSchizophrenia patientsNormal controlsNormal subjectsPatientsSignal detection theorySimilar deficitsImpaired detectionCore deficitAttention impairmentMotion stimuliSensory modalitiesVisual tasksResponse biasVisual motionRecent reportsAuditory detectionDetection theoryTrialsDeficitsRandom dotsPsychometric functionsSignal intensitySensitivity variesGroupCoherent directionAltered performance of schizophrenia patients in an auditory detection and discrimination task: exploring the ‘self-monitoring’ model of hallucination
Li CS, Chen MC, Yang YY, Chen MC, Tsay PK. Altered performance of schizophrenia patients in an auditory detection and discrimination task: exploring the ‘self-monitoring’ model of hallucination. Schizophrenia Research 2002, 55: 115-128. PMID: 11955971, DOI: 10.1016/s0920-9964(01)00203-1.Peer-Reviewed Original ResearchConceptsAuditory detectionDiscrimination taskSchizophrenia patientsModel of hallucinationsSelf-generated eventsSignal detection theoryPerceptual decisionsPerceptual signalsResponse biasPerceptual channelsPsychophysical studiesDetection theoryOnline processingPsychometric functionsAltered performanceCorollary dischargeConsistent supportMood disordersTaskHallucinationsBiasHallucinatingImpairmentTheoryPatient controls