2023
The effects of cocaine use severity and abstinence on behavioral performance and neural processes of response inhibition
Li G, Zhang Z, Zhang Y, Tang X, Li C. The effects of cocaine use severity and abstinence on behavioral performance and neural processes of response inhibition. Psychiatry Research Neuroimaging 2023, 336: 111734. PMID: 37871409, DOI: 10.1016/j.pscychresns.2023.111734.Peer-Reviewed Original ResearchConceptsDays of abstinenceStop-signal reaction timeHealthy controlsCocaine dependenceSuperior temporal gyrusCocaine use severityStop-signal taskCocaine useResponse inhibitionUse severityBilateral superior temporal gyrusFunctional magnetic resonanceWhole-brain regressionNeural processesPoor response inhibitionInhibition dysfunctionCerebral markersTemporal gyrusSTG activityAbstinenceSuccess trialsSeverityNeural mechanismsInhibitionBehavioral performance
2022
Acute effects of ketamine and esketamine on cognition in healthy subjects: A meta-analysis
Zhornitsky S, Tourjman V, Pelletier J, Assaf R, Li CR, Potvin S. Acute effects of ketamine and esketamine on cognition in healthy subjects: A meta-analysis. Progress In Neuro-Psychopharmacology And Biological Psychiatry 2022, 118: 110575. PMID: 35568275, DOI: 10.1016/j.pnpbp.2022.110575.Peer-Reviewed Original ResearchConceptsVerbal learningCognitive domainsResponse inhibitionAcute ketamine administrationVerbal learning/memorySpeed of processingLearning/memorySocial cognitionVerbal memoryExecutive functionVisual learningVisuospatial abilitiesMemory figuresCognitionMemoryCognitive impairmentAcute ketamineKetamine administrationEffect sizeLearningImpairmentModerate impairmentDeficitsNegative effectsHealthy individuals
2021
Distinct patterns of prefrontal cortical disengagement during inhibitory control in addiction: A meta-analysis based on population characteristics
Le TM, Potvin S, Zhornitsky S, Li CR. Distinct patterns of prefrontal cortical disengagement during inhibitory control in addiction: A meta-analysis based on population characteristics. Neuroscience & Biobehavioral Reviews 2021, 127: 255-269. PMID: 33933507, PMCID: PMC8411123, DOI: 10.1016/j.neubiorev.2021.04.028.Peer-Reviewed Original ResearchConceptsDorsal anterior cingulate cortexMiddle frontal gyrusHealthy controlsLeft dorsal anterior cingulate cortexMFG activationSubstance use statusPrefrontal cortical dysfunctionAnterior cingulate cortexPrefrontal cortical regionsResponse inhibitionPopulation characteristicsImpaired task performanceInhibitory control deficitsCortical dysfunctionCerebral functionBenefits of abstinenceNicotine usersCortical activationCingulate cortexCortical regionsFrontal gyrusBrain activationDrug addictionUse statusControl deficits
2019
Neural correlates of enhanced response inhibition in the aftermath of stress
Chang J, Hu J, Li CR, Yu R. Neural correlates of enhanced response inhibition in the aftermath of stress. NeuroImage 2019, 204: 116212. PMID: 31546050, PMCID: PMC7509808, DOI: 10.1016/j.neuroimage.2019.116212.Peer-Reviewed Original ResearchConceptsInhibitory controlAcute stressMagnetic resonance imaging studySignal taskResonance imaging studyFunctional magnetic resonance imaging studyMiddle frontal gyrusTrier Social Stress TestControl conditionSignal reaction timeAftermath of stressSocial Stress TestImaging studiesCognitive functionDynamic causal modelingStress exposureEnhanced response inhibitionPilot studyFrontal gyrusLife stressNeural mechanismsStriatumResponse inhibitionNeural correlatesImmediate effectsPosterior Cingulate Cortical Response to Active Avoidance Mediates the Relationship between Punishment Sensitivity and Problem Drinking
Le TM, Zhornitsky S, Wang W, Ide J, Zhang S, Li CR. Posterior Cingulate Cortical Response to Active Avoidance Mediates the Relationship between Punishment Sensitivity and Problem Drinking. Journal Of Neuroscience 2019, 39: 6354-6364. PMID: 31189577, PMCID: PMC6687909, DOI: 10.1523/jneurosci.0508-19.2019.Peer-Reviewed Original ResearchConceptsPosterior cingulate cortexMaladaptive coping mechanismPunishment sensitivityNeural substratesBehavioral avoidanceResponse inhibitionNegative affectAlcohol usePosterior cingulate cortex activationCoping mechanismsProblem drinkingAlcohol misusePCC responseSensation-seeking traitsAvoidance strategiesAlcohol Use Disorders Identification TestHazardous alcohol useAvoidance tendenciesAlcohol Use Disorders Identification Test (AUDIT) scoresGo taskNeural processesReward QuestionnaireAction inhibitionBrain activationCerebral correlates
2018
Structural and functional cerebral bases of diminished inhibitory control during healthy aging
Hu S, Ide JS, Chao HH, Castagna B, Fischer KA, Zhang S, Li C. Structural and functional cerebral bases of diminished inhibitory control during healthy aging. Human Brain Mapping 2018, 39: 5085-5096. PMID: 30113124, PMCID: PMC6287913, DOI: 10.1002/hbm.24347.Peer-Reviewed Original ResearchConceptsProlonged stop signal reaction timeStop-signal reaction timeAge-related reductionInhibitory controlFunctional changesPrefrontal cortexAge-related diminutionSignal taskRight dorsolateral prefrontal cortexSame brain regionsFunctional magnetic resonance imagingMagnetic resonance imagingMedial prefrontal cortexInferior parietal cortexResponse inhibitionDorsolateral prefrontal cortexInferior frontal cortexDiminished inhibitory controlCerebral changesStructure-function associationsSignal reaction timeCaudate headAge-related differencesStop-signal taskFrontal cortexLevodopa improves response inhibition and enhances striatal activation in early-stage Parkinson's disease
Manza P, Schwartz G, Masson M, Kann S, Volkow ND, Li CR, Leung HC. Levodopa improves response inhibition and enhances striatal activation in early-stage Parkinson's disease. Neurobiology Of Aging 2018, 66: 12-22. PMID: 29501966, PMCID: PMC6436810, DOI: 10.1016/j.neurobiolaging.2018.02.003.Peer-Reviewed Original ResearchConceptsEarly-stage Parkinson's diseaseParkinson's diseaseDopaminergic medicationAdvanced Parkinson's diseaseStriatal activationResponse inhibitionRole of dopaminergicAge-matched controlsFunctional magnetic resonance imagingMagnetic resonance imagingExecutive functionLevodopa monotherapyMultiple medicationsMotor symptomsSignificant group differencesPD groupStop-signal taskAdvanced stageLevodopaResonance imagingMedicationsFunctional connectivityCritical executive functionMotor inhibitionPatients
2017
Response inhibition in Parkinson’s disease: a meta-analysis of dopaminergic medication and disease duration effects
Manza P, Amandola M, Tatineni V, Li CR, Leung HC. Response inhibition in Parkinson’s disease: a meta-analysis of dopaminergic medication and disease duration effects. Npj Parkinson's Disease 2017, 3: 23. PMID: 28702504, PMCID: PMC5501877, DOI: 10.1038/s41531-017-0024-2.Peer-Reviewed Original ResearchDopamine replacement therapyEarly-stage Parkinson's diseaseDisease durationParkinson's diseaseDopaminergic medicationDopaminergic drugsDisease patientsResponse inhibitionCognitive functionDisease duration effectHallmark motor symptomsParkinson's disease durationShorter disease durationAdvanced Parkinson's diseaseParkinson's disease patientsRole of dopamineResponse inhibition deficitsMotor symptomsBasal gangliaHealthy controlsMedication statusMedicationsPatientsCognitive deficitsNeurodegenerative disorders
2016
The Right Superior Frontal Gyrus and Individual Variation in Proactive Control of Impulsive Response
Hu S, Ide JS, Zhang S, Li CR. The Right Superior Frontal Gyrus and Individual Variation in Proactive Control of Impulsive Response. Journal Of Neuroscience 2016, 36: 12688-12696. PMID: 27974616, PMCID: PMC5157110, DOI: 10.1523/jneurosci.1175-16.2016.Peer-Reviewed Original ResearchConceptsStop-signal reaction timeRight superior frontal gyrusSuperior frontal gyrusConflict anticipationProactive controlFrontal gyrusImpulsive responsesCognitive controlSignal taskInhibitory controlImpulse controlRegional activationEfficient response inhibitionReaction time differencesMotor urgencyVentromedial prefrontal cortexStop-signal taskYoung adultsSignal reaction timePosterior cingulate cortexIndividual variationError RTAction restraintNeural basisResponse inhibitionA dual but asymmetric role of the dorsal anterior cingulate cortex in response inhibition and switching from a non-salient to salient action
Manza P, Hu S, Chao HH, Zhang S, Leung HC, Li CS. A dual but asymmetric role of the dorsal anterior cingulate cortex in response inhibition and switching from a non-salient to salient action. NeuroImage 2016, 134: 466-474. PMID: 27126003, PMCID: PMC4912860, DOI: 10.1016/j.neuroimage.2016.04.055.Peer-Reviewed Original ResearchConceptsDorsal anterior cingulate cortexStop-signal reaction timeAnterior cingulate cortexSignal reaction timeCingulate cortexResponse inhibitionMotor inhibitionPre-supplementary motor areaRegional activationPre-SMA functionRegional brain activationMotor response inhibitionMotor areaStop trialsSalience processingBrain activationSalience detectionSuccess trialsSignal taskTrialsInhibitionSuccessful inhibitionInfrequent stimuliCortexActivationAssociation of Drinking Problems and Duration of Alcohol Use to Inhibitory Control in Nondependent Young Adult Social Drinkers
Hu S, Zhang S, Chao HH, Krystal JH, Li CS. Association of Drinking Problems and Duration of Alcohol Use to Inhibitory Control in Nondependent Young Adult Social Drinkers. Alcohol Clinical And Experimental Research 2016, 40: 319-328. PMID: 26833431, PMCID: PMC4742397, DOI: 10.1111/acer.12964.Peer-Reviewed Original ResearchConceptsAlcohol Use Disorders Identification TestYears of drinkingStop-signal reaction timeAlcohol useAge-related changesAlcohol misuseInhibitory controlAUDIT scoresDrinking problemsNondependent drinkersProlonged stop signal reaction timeChronic alcohol useAnterior cingulate cortexPresupplementary motor areaDisorders Identification TestRight inferior frontal gyrusResponse inhibitionSuperior temporal gyrusYoung adult social drinkersFunctional magnetic resonanceAdult social drinkersSignal reaction timeCerebral responsesInferior frontal gyrusHigher AUDIT
2015
Independent component analysis of functional networks for response inhibition: Inter‐subject variation in stop signal reaction time
Zhang S, Tsai S, Hu S, Xu J, Chao HH, Calhoun VD, Li C. Independent component analysis of functional networks for response inhibition: Inter‐subject variation in stop signal reaction time. Human Brain Mapping 2015, 36: 3289-3302. PMID: 26089095, PMCID: PMC4545723, DOI: 10.1002/hbm.22819.Peer-Reviewed Original ResearchConceptsStop-signal reaction timeStop-signal taskCognitive controlSignal reaction timeResponse inhibitionStop successBeta weightsReaction timeCritical executive functionFunctional networksIndependent component analysisExecutive functionError trialsSignal taskComponent processesMotor preparationBrain networksBehavioral validityMotor regionsRace modelLinear modelingGeneral linear modelingLarge sampleIndependent componentsFMRIResponse Inhibition
Li C. Response Inhibition. 2015, 303-317. DOI: 10.1016/b978-0-12-397025-1.00248-7.Peer-Reviewed Original ResearchResponse inhibitionRight inferior frontal cortexStimulus-driven processesMotor response inhibitionInferior frontal cortexPresupplementary motor areaFunctional brain imagingIndividual brain regionsPsychological constructsNeural substratesComponent processesBehavioral paradigmsReactive controlMotor areaBrain regionsFrontal cortexBrain imagingConceptual frameworkCortexConstructsParadigmDistinctionMonkeys
2014
Cognitive Control in Opioid Dependence and Methadone Maintenance Treatment
Liao DL, Huang CY, Hu S, Fang SC, Wu CS, Chen WT, Lee TS, Chen PC, Li CS. Cognitive Control in Opioid Dependence and Methadone Maintenance Treatment. PLOS ONE 2014, 9: e94589. PMID: 24727743, PMCID: PMC3984179, DOI: 10.1371/journal.pone.0094589.Peer-Reviewed Original ResearchConceptsMethadone maintenance treatmentOpioid dependencePost-error slowingStop-signal reaction timePsychiatric comorbidityMaintenance treatmentCognitive controlAbstinence durationOpioid-dependent individualsResponse inhibitionHealthy control participantsMethadone treatmentSignal reaction timeCognitive dysfunctionMMT groupPsychiatric clinicSubstance misuseLonger abstinenceComorbiditiesHC participantsControl participantsDependent individualsSignal taskBehavioral adjustmentPublic health
2013
Neural bases of individual variation in decision time
Hu S, Tseng Y, Winkler AD, Li C. Neural bases of individual variation in decision time. Human Brain Mapping 2013, 35: 2531-2542. PMID: 24027122, PMCID: PMC4511156, DOI: 10.1002/hbm.22347.Peer-Reviewed Original ResearchConceptsStop-signal reaction timeSupplementary motor areaNeural basisSignal taskMovement timeTrial reaction timeStop-signal taskSignal reaction timeCaudate headReaction timeCognitive controlResponse inhibitionResponse selectionIndividual variationAccumulator modelBehavioral performanceComponent processesDecision timeLonger movement timesHuman behaviorMotor areaSimple taskBrain imagingSuccessful goTask
2012
Saliency Processing and Obesity: A Preliminary Imaging Study of the Stop Signal Task
Hendrick OM, Luo X, Zhang S, Li C. Saliency Processing and Obesity: A Preliminary Imaging Study of the Stop Signal Task. Obesity 2012, 20: 1796-1802. PMID: 21720427, PMCID: PMC3653271, DOI: 10.1038/oby.2011.180.Peer-Reviewed Original ResearchConceptsStop-signal taskObese femalesBrain activationCognitive controlAltered cerebral functionSupplementary motor areaSignal taskRegional brain activationInferior parietal cortexSaliency processingCerebral functionLean femalesMotor areaFunctional magnetic resonance imagesParietal cortexSimilar behavioral performanceImaging studiesStop trialsPreliminary imaging studyObesityMagnetic resonance imagesTrialsGreater activationResonance imagesResponse inhibitionDecreased saliency processing as a neural measure of Barratt impulsivity in healthy adults
Farr OM, Hu S, Zhang S, Li CS. Decreased saliency processing as a neural measure of Barratt impulsivity in healthy adults. NeuroImage 2012, 63: 1070-1077. PMID: 22885245, PMCID: PMC3472158, DOI: 10.1016/j.neuroimage.2012.07.049.Peer-Reviewed Original ResearchConceptsStop-signal reaction timeStop-signal taskMiddle frontal cortexCognitive controlTrait impulsivityResponse inhibitionComponent processesSaliency processingBarratt impulsivityCognitive control functionsLeft dorsolateral prefrontal cortexPost-error slowingRegional brain activationDorsolateral prefrontal cortexSignal reaction timeYoung adult participantsBarratt Impulsivity ScaleNeural measuresError processingSignal taskBrain activationPsychophysiological interactionImpulsivity scoresBIS-11Impulsivity Scale
2011
Functional networks for cognitive control in a stop signal task: Independent component analysis
Zhang S, Li C. Functional networks for cognitive control in a stop signal task: Independent component analysis. Human Brain Mapping 2011, 33: 89-104. PMID: 21365716, PMCID: PMC3674850, DOI: 10.1002/hbm.21197.Peer-Reviewed Original ResearchConceptsStop-signal taskCognitive controlFronto-parietal networkStop successError processingSignal taskComponent processesFunctional networksLeft fronto-parietal networkRight fronto-parietal networkSelf-referential processingCritical executive functionCortico-subcortical networksAttentional monitoringExecutive functionResponse inhibitionError trialsNeural processesIndependent component analysisBehavioral engagementMotor preparationMotor cortical networkCortical networksSE trialsLinear modeling
2009
A neural measure of behavioral engagement: Task-residual low-frequency blood oxygenation level-dependent activity in the precuneus
Zhang S, Li CS. A neural measure of behavioral engagement: Task-residual low-frequency blood oxygenation level-dependent activity in the precuneus. NeuroImage 2009, 49: 1911-1918. PMID: 19761851, PMCID: PMC2791356, DOI: 10.1016/j.neuroimage.2009.09.004.Peer-Reviewed Original ResearchConceptsBlood oxygenation level-dependent activityRegional brain activationLevel-dependent activityTask engagementNeural measuresNeural processesBrain activationPosterior cingulate cortexAttentional monitoringResponse inhibitionHuman cognitionPrefrontal activationSignal taskGreater activationBOLD activityBehavioral engagementCingulate cortexPrecuneusBrain regionsLow-frequency fluctuationsFractional amplitudeBrain imagingSeed regionIndependent component analysisEngagementFunctional Connectivity Delineates Distinct Roles of the Inferior Frontal Cortex and Presupplementary Motor Area in Stop Signal Inhibition
Duann JR, Ide JS, Luo X, Li CS. Functional Connectivity Delineates Distinct Roles of the Inferior Frontal Cortex and Presupplementary Motor Area in Stop Signal Inhibition. Journal Of Neuroscience 2009, 29: 10171-10179. PMID: 19675251, PMCID: PMC2769086, DOI: 10.1523/jneurosci.1300-09.2009.Peer-Reviewed Original ResearchConceptsMotor response inhibitionBasal ganglia circuitryPresupplementary motor areaInferior prefrontal cortexStop-signal inhibitionMotor areaRight inferior prefrontal cortexPrefrontal cortexResponse inhibitionSignal inhibitionRecent imaging literaturePrimary motor cortexMedial prefrontal cortexInferior frontal cortexMotor cortexFrontal cortexCortical areasPrimary siteVentral attention systemPreSMAGreater effective connectivityCortexFunctional interconnectivityPsychophysiological interactionGo trials