2023
Sex differences in the effects of trait anxiety and age on resting-state functional connectivities of the amygdala
Chaudhary S, Hu S, Hu K, Dominguez J, Chao H, Li C. Sex differences in the effects of trait anxiety and age on resting-state functional connectivities of the amygdala. Journal Of Affective Disorders Reports 2023, 14: 100646. PMID: 38105798, PMCID: PMC10723810, DOI: 10.1016/j.jadr.2023.100646.Peer-Reviewed Original ResearchResting-state functional connectivityAmygdala resting-state functional connectivityTrait anxietyFunctional connectivitySex differencesInferior temporal gyrusCalcarine cortexTask-based dataNeural basisIndividual differencesEmotional traitsSupramarginal gyrusEmotional disordersTemporal gyrusNeural markersPosterior insulaAnxietyEffect of ageGyrusIndependent samplesMultiple regressionCorrelatesAmygdalaResults AnxietyCortex
2021
Neural correlates of individual variation in two-back working memory and the relationship with fluid intelligence
Li G, Chen Y, Le TM, Wang W, Tang X, Li CR. Neural correlates of individual variation in two-back working memory and the relationship with fluid intelligence. Scientific Reports 2021, 11: 9980. PMID: 33976306, PMCID: PMC8113462, DOI: 10.1038/s41598-021-89433-8.Peer-Reviewed Original ResearchConceptsDorsal anterior cingulate cortexN-back performanceRight anterior insulaStandard Progressive Matrices testFluid intelligenceNeural correlatesReaction timePre-supplementary motor areaRaven's Standard Progressive Matrices testN-back taskIndividual variationHuman Connectome Project datasetProgressive Matrices TestProlonged response timeBilateral frontoparietal cortexAnterior cingulate cortexTwo-backNeural basisDorsal precuneusRSPM performanceNeural processesNeural substratesAnterior insulaCerebral correlatesCorrect itemsSex differences in neural responses to reward and the influences of individual reward and punishment sensitivity
Dhingra I, Zhang S, Zhornitsky S, Wang W, Le TM, Li CR. Sex differences in neural responses to reward and the influences of individual reward and punishment sensitivity. BMC Neuroscience 2021, 22: 12. PMID: 33639845, PMCID: PMC7913329, DOI: 10.1186/s12868-021-00618-3.Peer-Reviewed Original ResearchConceptsMonetary incentive delay taskFunctional magnetic resonance imagingNeural responsesSex differencesReward-related brain activationBilateral orbitofrontal cortexMagnetic resonance imagingIncentive delay taskWhole-brain regressionVisual cortexResonance imagingOrbitofrontal cortexBrain activationWomenSuccess rateFMRI studyMenDelay taskImaging literatureNeural sensitivityCortexNeural basisAffective functionsHigher SR scoresLarge wins
2019
Cue-elicited craving, thalamic activity, and physiological arousal in adult non-dependent drinkers
Wang W, Zhornitsky S, Le TM, Dhingra I, Zhang S, Krystal JH, Li CR. Cue-elicited craving, thalamic activity, and physiological arousal in adult non-dependent drinkers. Journal Of Psychiatric Research 2019, 116: 74-82. PMID: 31202048, PMCID: PMC6606341, DOI: 10.1016/j.jpsychires.2019.06.005.Peer-Reviewed Original ResearchConceptsSkin conductance responsesPhysiological arousalThalamic activityNeural processesNeutral cue exposureMediation analysisHigher skin conductance responsesCue exposure paradigmCue-related activationsCue-elicited cravingCue-elicited drugNon-dependent drinkersImportant sex differencesSkin conductance dataPharmacological therapyAlcohol drinkersNeural targetsAlcohol cravingExposure paradigmCue exposureNeural correlatesNeural basisConductance responsesWomenCue activity
2017
Depression in chronic ketamine users: Sex differences and neural bases
Li CR, Zhang S, Hung CC, Chen CM, Duann JR, Lin CP, Lee TS. Depression in chronic ketamine users: Sex differences and neural bases. Psychiatry Research Neuroimaging 2017, 269: 1-8. PMID: 28892733, PMCID: PMC5634929, DOI: 10.1016/j.pscychresns.2017.09.001.Peer-Reviewed Original ResearchConceptsHealthy controlsSgACC connectivityChronic ketamine usersKetamine usersOrbitofrontal cortexEpidemiological Studies Depression ScaleSubgenual anterior cingulate cortexSex differencesPathogenesis of depressionCES-D scoresState functional connectivityBilateral superior temporal gyrusChronic ketamine useAnterior cingulate cortexSuperior temporal gyrusNeural basisDepression ScaleDorsomedial prefrontal cortexDepression scoresDepression severityKetamine useCingulate cortexTemporal gyrusFunctional connectivityPrefrontal cortexSex differences in the interacting roles of impulsivity and positive alcohol expectancy in problem drinking: A structural brain imaging study
Ide JS, Zhornitsky S, Hu S, Zhang S, Krystal JH, Li CR. Sex differences in the interacting roles of impulsivity and positive alcohol expectancy in problem drinking: A structural brain imaging study. NeuroImage Clinical 2017, 14: 750-759. PMID: 28413777, PMCID: PMC5385596, DOI: 10.1016/j.nicl.2017.03.015.Peer-Reviewed Original ResearchConceptsPositive alcohol expectanciesGray matter volumeAlcohol expectanciesAlcohol Use Disorders Identification TestSocial drinkersNon-dependent social drinkersProblem drinkingRole of impulsivityBrain imaging studiesRight posterior insulaSex differencesStructural brain imagingStructural brain imaging studiesNeural basisDisorders Identification TestBarratt impulsivityPsychological factorsImpulsivityMediation analysisPosterior insulaDependent individualsRisk factorsAlcohol misuseLinear modelingGeneral linear modelingThe Effects of Age, from Young to Middle Adulthood, and Gender on Resting State Functional Connectivity of the Dopaminergic Midbrain
Peterson AC, Zhang S, Hu S, Chao HH, Li CR. The Effects of Age, from Young to Middle Adulthood, and Gender on Resting State Functional Connectivity of the Dopaminergic Midbrain. Frontiers In Human Neuroscience 2017, 11: 52. PMID: 28223929, PMCID: PMC5293810, DOI: 10.3389/fnhum.2017.00052.Peer-Reviewed Original ResearchSubstantia nigra pars compactaVentral tegmental areaAttention-deficit/ hyperactivity disorderState functional connectivityAge-related changesEffect of ageFunctional connectivityParahippocampal gyrusParkinson's diseaseMiddle adulthoodDopaminergic ventral tegmental areaBilateral angular gyrusOrbital frontal regionsBlood oxygenation level-dependent (BOLD) signalLevel-dependent signalPosterior orbital gyrusTime courseNeural basisDopaminergic midbrainHyperactivity disorderNeural mechanismsAngular gyrusPars compactaFrontal regionsDopaminergic structures
2016
The Right Superior Frontal Gyrus and Individual Variation in Proactive Control of Impulsive Response
Hu S, Ide JS, Zhang S, Li CR. The Right Superior Frontal Gyrus and Individual Variation in Proactive Control of Impulsive Response. Journal Of Neuroscience 2016, 36: 12688-12696. PMID: 27974616, PMCID: PMC5157110, DOI: 10.1523/jneurosci.1175-16.2016.Peer-Reviewed Original ResearchConceptsStop-signal reaction timeRight superior frontal gyrusSuperior frontal gyrusConflict anticipationProactive controlFrontal gyrusImpulsive responsesCognitive controlSignal taskInhibitory controlImpulse controlRegional activationEfficient response inhibitionReaction time differencesMotor urgencyVentromedial prefrontal cortexStop-signal taskYoung adultsSignal reaction timePosterior cingulate cortexIndividual variationError RTAction restraintNeural basisResponse inhibition
2015
Barratt Impulsivity and Neural Regulation of Physiological Arousal
Zhang S, Hu S, Hu J, Wu PL, Chao HH, Li CS. Barratt Impulsivity and Neural Regulation of Physiological Arousal. PLOS ONE 2015, 10: e0129139. PMID: 26079873, PMCID: PMC4469608, DOI: 10.1371/journal.pone.0129139.Peer-Reviewed Original ResearchConceptsSkin conductance responsesImpulsive individualsNeural basisPhysiological arousalArousal regulationHigh impulsivityBarratt impulsivitySkin conductanceGreater skin conductance responsesFunctional magnetic resonance imagingVentromedial prefrontal cortexStop-signal taskTheory of personalityBarratt Impulsivity ScalePoor impulse controlVmPFC activitySalient stimuliExternal stimulationImpulsive womenNeural processesNeural substratesSignal taskConductance responsesImpulsivity ScaleImpulsivity
2014
The Effects of Methylphenidate on Cerebral Activations to Salient Stimuli in Healthy Adults
Farr OM, Hu S, Matuskey D, Zhang S, Abdelghany O, Li CS. The Effects of Methylphenidate on Cerebral Activations to Salient Stimuli in Healthy Adults. Experimental And Clinical Psychopharmacology 2014, 22: 154-165. PMID: 24188171, PMCID: PMC4105943, DOI: 10.1037/a0034465.Peer-Reviewed Original ResearchConceptsStop-signal taskSalient stimuliSaliency processingFunctional MRIAttention deficit hyperactivity disorderRight inferior parietal cortexHigh motivational valueDeficit hyperactivity disorderEffects of methylphenidateInferior parietal cortexHealthy adultsNeural basisCognitive functioningMotivational valueAttention disordersHyperactivity disorderBilateral caudate headCatecholaminergic signalingMethylphenidate groupParietal cortexCerebral activationHigher activationCatecholaminergic treatmentPrimary motor cortexCerebral activity
2013
Neural bases of individual variation in decision time
Hu S, Tseng Y, Winkler AD, Li C. Neural bases of individual variation in decision time. Human Brain Mapping 2013, 35: 2531-2542. PMID: 24027122, PMCID: PMC4511156, DOI: 10.1002/hbm.22347.Peer-Reviewed Original ResearchConceptsStop-signal reaction timeSupplementary motor areaNeural basisSignal taskMovement timeTrial reaction timeStop-signal taskSignal reaction timeCaudate headReaction timeCognitive controlResponse inhibitionResponse selectionIndividual variationAccumulator modelBehavioral performanceComponent processesDecision timeLonger movement timesHuman behaviorMotor areaSimple taskBrain imagingSuccessful goTask