2022
Effects of androgen deprivation on white matter integrity and processing speed in prostate cancer patients.
Chaudhary S, Roy A, Summers C, Ahles T, Li C, Chao H. Effects of androgen deprivation on white matter integrity and processing speed in prostate cancer patients. American Journal Of Cancer Research 2022, 12: 4802-4814. PMID: 36381311, PMCID: PMC9641391.Peer-Reviewed Original ResearchAndrogen deprivation therapyProstate cancer patientsWhite matter integrityCancer patientsAndrogen deprivationFractional anisotropyNon-metastatic prostate cancerSignificant FA changesImpaired white matter integrityPosterior corona radiataAnterior thalamic radiationDiffusion tensor imagingADT patientsDeprivation therapyProspective studyCorpus callosumProstate cancerCorona radiataYears of educationThalamic radiationPatientsWhole brainCognitive deficitsCognitive functionTensor imagingSerum hyperhomocysteine and cognitive impairment in first-episode patients with schizophrenia: Moderated by brain cortical thickness
Lin C, Gou M, Pan S, Tong J, Zhou Y, Xie T, Yu T, Feng W, Li Y, Chen S, Tian B, Tan S, Wang Z, Luo X, Li CR, Zhang P, Huang J, Hong L, Tan Y. Serum hyperhomocysteine and cognitive impairment in first-episode patients with schizophrenia: Moderated by brain cortical thickness. Neuroscience Letters 2022, 788: 136826. PMID: 35944595, DOI: 10.1016/j.neulet.2022.136826.Peer-Reviewed Original ResearchConceptsBrain cortical thicknessCognitive impairmentCognitive deficitsGray matter thicknessSchizophrenia (MATRICS) Consensus Cognitive BatteryAttention/vigilanceConsensus Cognitive BatteryCortical thicknessSerum Hcy levelsFirst-episode patientsHealthy controlsHigh homocysteineWorking memoryHcy levelsCognitive batteryNegative Symptom ScaleCognitive functionTreatment researchHigh-resolution magnetic resonance imagingSymptom ScaleSandwich enzyme-linked immunosorbentSchizophreniaHigher cortical thicknessImpairmentEnzyme-linked immunosorbentChildhood trauma and cognitive deficits in patients with schizophrenia: mediation by orbitofrontal cortex H-shaped sulci volume
Wang L, Yin Y, Feng W, Zhou Y, Huang J, Zhang P, Chen S, Fan H, Cui Y, Luo X, Tan S, Wang Z, Tian B, Tian L, Li CR, Tan Y. Childhood trauma and cognitive deficits in patients with schizophrenia: mediation by orbitofrontal cortex H-shaped sulci volume. Journal Of Psychiatry And Neuroscience 2022, 47: e209-e217. PMID: 35654451, PMCID: PMC9177195, DOI: 10.1503/jpn.210178.Peer-Reviewed Original ResearchConceptsFirst-episode schizophreniaCTQ total scoresHealthy controlsCognitive functionChildhood Trauma QuestionnaireTotal scoreCognitive deficitsChildhood trauma experiencesMATRICS Consensus Cognitive BatteryChildhood traumaOrbitofrontal cortexWorse cognitive functionTrauma experiencesHigh-resolution MRIRetrospective designPatientsConsensus Cognitive BatterySchizophreniaTraumaSubscoresSmall sample sizeTrauma QuestionnaireComposite scoreLines of evidenceScoresEmotion Processing Dysfunction in Alzheimer’s Disease: An Overview of Behavioral Findings, Systems Neural Correlates, and Underlying Neural Biology
Chaudhary S, Zhornitsky S, Chao HH, van Dyck CH, Li CR. Emotion Processing Dysfunction in Alzheimer’s Disease: An Overview of Behavioral Findings, Systems Neural Correlates, and Underlying Neural Biology. American Journal Of Alzheimer's Disease & Other Dementias® 2022, 37: 15333175221082834. PMID: 35357236, PMCID: PMC9212074, DOI: 10.1177/15333175221082834.Peer-Reviewed Original ResearchConceptsEmotional processing deficitsProcessing dysfunctionProcessing deficitsMultiple behavioral paradigmsEmotional memoryEmotional stimuliPositive emotionsAltered emotionsNegative emotionsNeural correlatesEmotional processing dysfunctionAmygdala reactivityBehavioral findingsEmotional disordersCognitive deficitsBehavioral paradigmsProminent deficitsEmotionsAlzheimer's diseaseBehavioral studiesLongitudinal studyNoradrenergic signalingDeficitsCircuit dysfunctionMemoryDysfunctional monocytic toll-like receptor 4 signaling pathway and cognitive deficits in chronic schizophrenia patients with tardive dyskinesia
Li N, Li Y, Huang J, Zhang P, Tong J, Chen S, Cui Y, Tan S, Wang Z, Yang F, Hong E, Li CR, Tian L, Tan Y. Dysfunctional monocytic toll-like receptor 4 signaling pathway and cognitive deficits in chronic schizophrenia patients with tardive dyskinesia. Neuroscience Letters 2022, 777: 136581. PMID: 35337952, DOI: 10.1016/j.neulet.2022.136581.Peer-Reviewed Original ResearchConceptsToll-like receptor 4Abnormal Involuntary Movement ScaleTardive dyskinesiaChronic schizophrenia patientsSchizophrenia patientsMATRICS Consensus Cognitive BatteryReceptor 4TD patientsHigher toll-like receptor 4Cognitive deficitsSeverity of TDNegative Syndrome ScaleInnate immune systemNTD patientsTLR4 levelsHealthy controlsAIMS scoresMovement ScalePatientsConsensus Cognitive BatteryLPS stimulationTLR4 signalsPathway disturbancesLipopolysaccharide (LPS) stimulationSyndrome Scale
2021
Effects of microRNA-181b-5p on cognitive deficits in first-episode patients with schizophrenia: Mediated by BCL-2
Gou M, Pan S, Tong J, Zhou Y, Han J, Xie T, Yu T, Feng W, Li Y, Chen S, Cui Y, Tian B, Tan MDS, Wang Z, Luo X, Li CR, Zhang P, Huang J, Hong LE, Tan Y, Tian L. Effects of microRNA-181b-5p on cognitive deficits in first-episode patients with schizophrenia: Mediated by BCL-2. Journal Of Psychiatric Research 2021, 136: 358-365. PMID: 33636692, DOI: 10.1016/j.jpsychires.2021.02.003.Peer-Reviewed Original ResearchConceptsFirst-episode patientsBcl-2 mRNAEnzyme Linked Immunosorbent AssayMATRICS Consensus Cognitive BatteryQuantitative real-time PCRCognitive deficitsCognitive functionGender-matched healthy controlsBcl-2Pathogenesis of schizophreniaPeripheral whole bloodExpression levelsNegative Syndrome ScaleBcl-2 protein expressionLinked Immunosorbent AssayBcl-2 protein levelsPeripheral bloodHealthy controlsBcl-2 mRNA levelsReal-time PCRTarget genes Bcl-2Consensus Cognitive BatterySchizophrenia patientsSyndrome ScaleGene Bcl-2The microRNA-195 - BDNF pathway and cognitive deficits in schizophrenia patients with minimal antipsychotic medication exposure
Pan S, Feng W, Li Y, Huang J, Chen S, Cui Y, Tian B, Tan S, Wang Z, Yao S, Chiappelli J, Kochunov P, Chen S, Yang F, Li CR, Tian L, Tan Y, Elliot Hong L. The microRNA-195 - BDNF pathway and cognitive deficits in schizophrenia patients with minimal antipsychotic medication exposure. Translational Psychiatry 2021, 11: 117. PMID: 33558459, PMCID: PMC7870897, DOI: 10.1038/s41398-021-01240-x.Peer-Reviewed Original ResearchConceptsBDNF protein levelsBrain-derived neurotrophic factorAntipsychotic medication exposureBDNF protein expressionMATRICS Consensus Cognitive BatteryMiR-195Medication exposureBDNF mRNABDNF proteinCognitive functionProtein levelsCognitive impairmentLower BDNF protein levelsCognitive deficitsSex-matched healthy controlsProtein expressionSubgroup of patientsFirst-episode patientsMiR-195 expressionBDNF reductionMedication-naïveNeurotrophic factorPeripheral bloodHealthy controlsOverall cognitive performance
2020
Catechol-O-Methyltransferase Gene Polymorphisms and the Risk of Chemotherapy-Induced Prospective Memory Impairment in Breast Cancer Patients with Varying Tumor Hormonal Receptor Expression
Li W, Zhao J, Ding K, Chao HH, Li CR, Cheng H, Shen L. Catechol-O-Methyltransferase Gene Polymorphisms and the Risk of Chemotherapy-Induced Prospective Memory Impairment in Breast Cancer Patients with Varying Tumor Hormonal Receptor Expression. Medical Science Monitor 2020, 26: e923567-1-e923567-10. PMID: 32985495, PMCID: PMC7531203, DOI: 10.12659/msm.923567.Peer-Reviewed Original ResearchConceptsBreast cancer patientsHormonal receptor expressionCancer patientsReceptor expressionMemory impairmentProgesterone receptorBreast cancerEstrogen receptorG genotypeGene polymorphismsCognitive impairmentRisks of chemotherapyBreast cancer survivorsSingle nucleotide polymorphismsProspective memory impairmentCatechol-O-methyltransferase gene polymorphismExtent of deficitsMemory scoresER-/PRBDNF polymorphismCancer survivorsCognitive dysfunctionChemotherapyPatientsCognitive deficitsHippocampus and cognitive domain deficits in treatment-resistant schizophrenia: A comparison with matched treatment-responsive patients and healthy controls✰,✰✰,★,★★
Huang J, Zhu Y, Fan F, Chen S, Hong Y, Cui Y, Luo X, Tan S, Wang Z, Shang L, Yuan Y, Zhang J, Yang F, Li CR, Rowland LM, Kochunov P, Zhang F, Hong LE, Tan Y. Hippocampus and cognitive domain deficits in treatment-resistant schizophrenia: A comparison with matched treatment-responsive patients and healthy controls✰,✰✰,★,★★. Psychiatry Research Neuroimaging 2020, 297: 111043. PMID: 32062167, PMCID: PMC7490244, DOI: 10.1016/j.pscychresns.2020.111043.Peer-Reviewed Original ResearchTreatment-resistant schizophreniaTreatment-responsive patientsHippocampal volumeHealthy controlsSmaller total hippocampal volumesSmaller hippocampal volumesTotal hippocampal volumeAvailable antipsychotic medicationsSevere cognitive dysfunctionLogistic regression analysisSubgroup of schizophreniaGlobal cognitive deficitsCognitive domain deficitsSpecific deficitsAntipsychotic medicationCognitive dysfunctionTreatment resistanceHigh riskHC groupPatientsMemory deficitsCognitive deficitsCognitive functionSchizophreniaSignificant deficits
2019
Putamen gray matter volumes in neuropsychiatric and neurodegenerative disorders.
Luo X, Mao Q, Shi J, Wang X, Li CR. Putamen gray matter volumes in neuropsychiatric and neurodegenerative disorders. World Journal Of Psychiatry And Mental Health Research 2019, 3 PMID: 31328186, PMCID: PMC6641567.Peer-Reviewed Original ResearchGray matter volumePutamen volumeNeurodegenerative disordersMatter volumePutamen gray matter volumesSpectrum disorderParkinson's spectrum disordersAttention deficit hyperactivity disorderSchizophrenia spectrum disordersDeficit hyperactivity disorderMultiple sclerosisLewy bodiesObsessive-compulsive spectrum disordersMajor depressionTreatment outcomesMotor impairmentDopaminergic processesNeurodegenerative conditionsAmphetamine dependenceBipolar disorderAlzheimer's diseaseCognitive deficitsHuntington's diseaseDiseaseHyperactivity disorder
2018
The Comorbidity Between Internet Gaming Disorder and Depression: Interrelationship and Neural Mechanisms
Liu L, Yao YW, Li CR, Zhang JT, Xia CC, Lan J, Ma SS, Zhou N, Fang XY. The Comorbidity Between Internet Gaming Disorder and Depression: Interrelationship and Neural Mechanisms. Frontiers In Psychiatry 2018, 9: 154. PMID: 29740358, PMCID: PMC5924965, DOI: 10.3389/fpsyt.2018.00154.Peer-Reviewed Original ResearchInternet gaming disorderDorsolateral prefrontal cortexNeural mechanismsLeft amygdalaGaming disorderRight dorsolateral prefrontal cortexDepression symptomsPrecentral gyrusAutoregressive cross-lagged modelingBrain imaging researchExecutive control networkResting-state functional connectivity studyCross-lagged modelingFunctional connectivity studiesLongitudinal survey studyNeural levelBrain mechanismsEmotional deficitsPrefrontal cortexCognitive deficitsPsychotherapy interventionsControl participantsIGD severityCollege studentsConnectivity studies
2017
Response inhibition in Parkinson’s disease: a meta-analysis of dopaminergic medication and disease duration effects
Manza P, Amandola M, Tatineni V, Li CR, Leung HC. Response inhibition in Parkinson’s disease: a meta-analysis of dopaminergic medication and disease duration effects. Npj Parkinson's Disease 2017, 3: 23. PMID: 28702504, PMCID: PMC5501877, DOI: 10.1038/s41531-017-0024-2.Peer-Reviewed Original ResearchDopamine replacement therapyEarly-stage Parkinson's diseaseDisease durationParkinson's diseaseDopaminergic medicationDopaminergic drugsDisease patientsResponse inhibitionCognitive functionDisease duration effectHallmark motor symptomsParkinson's disease durationShorter disease durationAdvanced Parkinson's diseaseParkinson's disease patientsRole of dopamineResponse inhibition deficitsMotor symptomsBasal gangliaHealthy controlsMedication statusMedicationsPatientsCognitive deficitsNeurodegenerative disorders
2011
Deficits in default mode network activity preceding error in cocaine dependent individuals
Bednarski SR, Zhang S, Hong KI, Sinha R, Rounsaville BJ, Li CS. Deficits in default mode network activity preceding error in cocaine dependent individuals. Drug And Alcohol Dependence 2011, 119: e51-e57. PMID: 21703783, PMCID: PMC3188675, DOI: 10.1016/j.drugalcdep.2011.05.026.Peer-Reviewed Original ResearchConceptsDefault mode networkCocaine dependenceCocaine useHealthy controlsTask-related cerebral activationBlood oxygenation level-dependent (BOLD) signalDemographics-matched healthy controlsGray matter volumeDefault mode network activityLevel-dependent signalChronic cocaine useRegional brain activationPosterior cingulate cortexStatistical parametric mappingCerebral functionBilateral precuneusCocaine-dependent individualsCerebral activationHealthy peopleMatter volumeCingulate cortexVentromedial prefrontal cortexBrain regionsCognitive deficitsCocaine misuse
2002
Impairment of temporal attention in patients with schizophrenia
Li CS, Lin WH, Yang YY, Huang CC, Chen TW, Chen YC. Impairment of temporal attention in patients with schizophrenia. Neuroreport 2002, 13: 1427-1430. PMID: 12167767, DOI: 10.1097/00001756-200208070-00016.Peer-Reviewed Original ResearchConceptsRapid serial visual presentation taskCore cognitive deficitVisual presentation taskEducation-matched control subjectsNumber of distractorsSignal detection theoryAttentional blinkT2 detectionTemporal attentionPresentation taskAttention impairmentVisual stimuliTemporal deploymentCognitive deficitsDetection theorySchizophrenia patientsSchizophrenia subjectsRapid successionSchizophreniaImpairmentTemporal gatingAttentionDistractorsBlinkStimuli