2012
Linking DNA Methyltransferases to Epigenetic Marks and Nucleosome Structure Genome-wide in Human Tumor Cells
Jin B, Ernst J, Tiedemann R, Xu H, Sureshchandra S, Kellis M, Dalton S, Liu C, Choi J, Robertson K. Linking DNA Methyltransferases to Epigenetic Marks and Nucleosome Structure Genome-wide in Human Tumor Cells. Cell Reports 2012, 2: 1411-1424. PMID: 23177624, PMCID: PMC3625945, DOI: 10.1016/j.celrep.2012.10.017.Peer-Reviewed Original ResearchMeSH KeywordsCarcinoma, EmbryonalCell LineChromatinCpG IslandsDNADNA (Cytosine-5-)-Methyltransferase 1DNA (Cytosine-5-)-MethyltransferasesDNA MethylationDNA Methyltransferase 3AEmbryonic Stem CellsEpigenomicsGenes, OverlappingGenetic LociGenome, HumanHCT116 CellsHistonesHumansMaleNucleosomesProtein BindingTesticular NeoplasmsTranscription, GeneticConceptsDNA methylationDNA methyltransferasesDifferentiated stateGenome-wide localizationCancerous stem cellsEpigenetic marksMammalian developmentHistone modificationsNucleosome structureCellular transformationDNA hypermethylationLocalization patternsHuman tumor cellsMethylationDNMTsHuman tumor cell linesTumor cell linesStem cellsMethyltransferasesCancer cellsCell linesLociCellsTumor cellsEpigenome
2008
Identification of Liver Cancer-Specific Aptamers Using Whole Live Cells
Shangguan D, Meng L, Cao Z, Xiao Z, Fang X, Li Y, Cardona D, Witek R, Liu C, Tan W. Identification of Liver Cancer-Specific Aptamers Using Whole Live Cells. Analytical Chemistry 2008, 80: 721-728. PMID: 18177018, DOI: 10.1021/ac701962v.Peer-Reviewed Original ResearchConceptsLiver cancerLiver cancer cellsEarly diagnosisCell linesBALB/cJ miceCancer cellsSurgical resectionClinical outcomesLiver cell lineEffective treatmentMouse modelWhole live cellsDeadly cancerCurrent studyCancer-specific aptamersTumor selectionBasic mechanism studiesCancerMost cancersBNL CLCancer early diagnosisCell-SELEX methodNoncancer cell linesDiagnosisCancer recognition