2013
Linking metabolism and epigenetic regulation in development of hepatocellular carcinoma
Puszyk W, Le Trinh T, Chapple S, Liu C. Linking metabolism and epigenetic regulation in development of hepatocellular carcinoma. Laboratory Investigation 2013, 93: 983-990. PMID: 23917878, PMCID: PMC4028619, DOI: 10.1038/labinvest.2013.94.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCarcinoma, HepatocellularDNA MethylationEpigenomicsHumansLiver NeoplasmsMetabolomeMicroRNAsConceptsHepatocellular carcinomaLate-stage hepatocellular carcinomaDevelopment of HCCAltered liver metabolismHepatitis B virusMajor risk factorProgression of HCCHepatitis CLiver functionB virusMicro RNA expressionRisk factorsLiver metabolismMetabolic organSurvival rateCancerRNA expressionCommon formCarcinomaUnderlying metabolic processesLiverExogenous environmental factorsEnvironmental factorsExcessive consumptionExposure
2012
Linking DNA Methyltransferases to Epigenetic Marks and Nucleosome Structure Genome-wide in Human Tumor Cells
Jin B, Ernst J, Tiedemann R, Xu H, Sureshchandra S, Kellis M, Dalton S, Liu C, Choi J, Robertson K. Linking DNA Methyltransferases to Epigenetic Marks and Nucleosome Structure Genome-wide in Human Tumor Cells. Cell Reports 2012, 2: 1411-1424. PMID: 23177624, PMCID: PMC3625945, DOI: 10.1016/j.celrep.2012.10.017.Peer-Reviewed Original ResearchMeSH KeywordsCarcinoma, EmbryonalCell LineChromatinCpG IslandsDNADNA (Cytosine-5-)-Methyltransferase 1DNA (Cytosine-5-)-MethyltransferasesDNA MethylationDNA Methyltransferase 3AEmbryonic Stem CellsEpigenomicsGenes, OverlappingGenetic LociGenome, HumanHCT116 CellsHistonesHumansMaleNucleosomesProtein BindingTesticular NeoplasmsTranscription, GeneticConceptsDNA methylationDNA methyltransferasesDifferentiated stateGenome-wide localizationCancerous stem cellsEpigenetic marksMammalian developmentHistone modificationsNucleosome structureCellular transformationDNA hypermethylationLocalization patternsHuman tumor cellsMethylationDNMTsHuman tumor cell linesTumor cell linesStem cellsMethyltransferasesCancer cellsCell linesLociCellsTumor cellsEpigenome