2018
The neurobiology of depression, ketamine and rapid-acting antidepressants: Is it glutamate inhibition or activation?
Abdallah CG, Sanacora G, Duman RS, Krystal JH. The neurobiology of depression, ketamine and rapid-acting antidepressants: Is it glutamate inhibition or activation? Pharmacology & Therapeutics 2018, 190: 148-158. PMID: 29803629, PMCID: PMC6165688, DOI: 10.1016/j.pharmthera.2018.05.010.Peer-Reviewed Original ResearchConceptsRapid-acting antidepressantsNeurobiology of depressionMechanism of actionChronic stress pathologyRole of glutamateAntidepressant effectsEfficacy findingsGlutamate activationBiomarker findingsNeurobiology of stressVivo pharmacodynamicsCurrent perspective paperKetamineChronic stressReproducible biomarkersBehavioral effectsGlutamate inhibitionDepressionStress pathologyAntidepressantsNeurobiologyInhibitionActivationPharmacodynamicsPharmacokinetics
2016
Ketamine’s Mechanism of Rapid Antidepressant Activity: Evidence Gleaned from Clinical Studies
Averill L, Murrough J, Abdallah C. Ketamine’s Mechanism of Rapid Antidepressant Activity: Evidence Gleaned from Clinical Studies. 2016, 99-121. DOI: 10.1007/978-3-319-42925-0_7.Peer-Reviewed Original ResearchRapid antidepressant effectsNeurobiology of depressionRapid antidepressant actionsNovel drug developmentDrug developmentKetamine's rapid antidepressant effectsRapid antidepressant activityOpen-label trialAntidepressant drug developmentKetamine's rapid antidepressant actionsTrauma-related disordersAntidepressant actionAntidepressant effectsAntidepressant medicationKetamine's mechanismSafety profileKetamine responseAntidepressant activityClinical studiesPotential biomarkersPsychotherapeutic treatmentHuman subjectsMedical SciencesDepressionNeurobiology