2010
Computerized ambulatory monitoring in mood disorders: Feasibility, compliance, and reactivity
Husky MM, Gindre C, Mazure CM, Brebant C, Nolen-Hoeksema S, Sanacora G, Swendsen J. Computerized ambulatory monitoring in mood disorders: Feasibility, compliance, and reactivity. Psychiatry Research 2010, 178: 440-442. PMID: 20488558, DOI: 10.1016/j.psychres.2010.04.045.Peer-Reviewed Original Research
2007
Depressive Symptoms and Sex Affect Completion Rates and Clinical Outcomes in Cardiac Rehabilitation
Caulin‐Glaser T, Maciejewski PK, Snow R, LaLonde M, Mazure C. Depressive Symptoms and Sex Affect Completion Rates and Clinical Outcomes in Cardiac Rehabilitation. Preventive Cardiology 2007, 10: 15-21. PMID: 17215628, DOI: 10.1111/j.1520-037.2007.05666.x.Peer-Reviewed Original ResearchConceptsBDI-II scoresClinical outcomesDepressive symptomsMultiple logistic regression analysisCardiac rehabilitation completionBody mass indexCoronary heart diseaseLogistic regression analysisSymptoms of depressionLower BDI-II scoresRehabilitation completionExercise capacityCardiac rehabilitationCardiovascular benefitsMass indexCR programCardiovascular healthHeart diseaseLipid profileSymptomsPatientsIndependent effectsWomenRegression analysisCompletion rates
2003
Discontinuation of Antidepressants in Newly Admitted Psychotic Patients
Bowers MB, McKay BG, Mazure CM. Discontinuation of Antidepressants in Newly Admitted Psychotic Patients. Journal Of Neuropsychiatry 2003, 15: 227-230. PMID: 12724466, DOI: 10.1176/jnp.15.2.227.Peer-Reviewed Original ResearchPsychotic Depression and Mortality
Vythilingam M, Chen J, Bremner JD, Mazure CM, Maciejewski PK, Nelson JC. Psychotic Depression and Mortality. American Journal Of Psychiatry 2003, 160: 574-576. PMID: 12611843, DOI: 10.1176/appi.ajp.160.3.574.Peer-Reviewed Original ResearchConceptsPsychotic depressionNonpsychotic major depressionHigh mortality rateMortality rateMajor depressionHospital admissionNonpsychotic depressionVital statusMedical statusCumulative Illness Rating ScaleIllness Rating ScaleMajor depressive disorderProportional hazards modelSeverity of depressionPsychotic major depressionPositive DST resultsSurvival analytic techniquesElevated mortality ratesDepressive disorderDST resultsHazards modelPatientsGreater riskRating ScaleDepression
2002
Plasma catecholamine metabolites in antidepressant-exacerbated mania and psychosis
Fortunati F, Mazure C, Preda A, Wahl R, Bowers M. Plasma catecholamine metabolites in antidepressant-exacerbated mania and psychosis. Journal Of Affective Disorders 2002, 68: 331-334. PMID: 12063160, DOI: 10.1016/s0165-0327(00)00327-x.Peer-Reviewed Original Research
1998
Pretreatment plasma HVA predicts neuroleptic response in manic psychosis
Mazure C, Bowers M. Pretreatment plasma HVA predicts neuroleptic response in manic psychosis. Journal Of Affective Disorders 1998, 48: 83-86. PMID: 9495606, DOI: 10.1016/s0165-0327(97)00159-6.Peer-Reviewed Original ResearchAcute Neuroleptic Treatment in Elderly Patients Without Dementia
Mazure C, Nelson J, Jatlow P, Bowers M. Acute Neuroleptic Treatment in Elderly Patients Without Dementia. American Journal Of Geriatric Psychiatry 1998, 6: 221-229. PMID: 9659955, DOI: 10.1097/00019442-199800630-00005.Peer-Reviewed Original ResearchConceptsNon-elderly adultsElderly patientsNeuroleptic treatmentAcute responseLow dosesLow-dose neuroleptic treatmentAcute neuroleptic treatmentAdverse effectsHigh-dose treatmentLow-dose treatmentDrug blood levelsPrimary psychotic illnessInitial doseBlood levelsPsychotic illnessEffective treatmentPatientsDose ratioLonger durationTreatmentLower ratesDosesAdultsResponseNeurolepticsManagement of the Adverse Effects of Clozapine
Young CR, Bowers MB, Mazure CM. Management of the Adverse Effects of Clozapine. Schizophrenia Bulletin 1998, 24: 381-390. PMID: 9718630, DOI: 10.1093/oxfordjournals.schbul.a033333.Peer-Reviewed Original ResearchConceptsAdverse effectsElevated liver enzymesPercent of patientsSuccessful pharmacological managementPositive therapeutic outcomesHypothesized pathophysiologyPharmacological managementRefractory schizophreniaNeuromuscular effectsTraditional neurolepticsLiver enzymesPharmacological interventionsClozapineAffective disordersTherapeutic outcomesNeurological disordersMental disordersMaximum doseObsessive-compulsive symptomsWeight gainDisordersPatientsPathophysiologyNew hopeTreatmentMeasurement of dissociative states with the Clinician‐Administered Dissociative States Scale (CADSS)
Bremner J, Krystal J, Putnam F, Southwick S, Marmar C, Charney D, Mazure C. Measurement of dissociative states with the Clinician‐Administered Dissociative States Scale (CADSS). Journal Of Traumatic Stress 1998, 11: 125-136. PMID: 9479681, DOI: 10.1023/a:1024465317902.Peer-Reviewed Original Research
1997
The Expanding Indications for Clozapine
Young C, Longhurst J, Bowers M, Mazure C. The Expanding Indications for Clozapine. Experimental And Clinical Psychopharmacology 1997, 5: 216-234. PMID: 9260069, DOI: 10.1037/1064-1297.5.3.216.Peer-Reviewed Original ResearchConceptsUnique pharmacodynamic profileUse of clozapineTreatment-resistant schizophreniaTraditional drug treatmentExpanding IndicationsClozapine treatmentNeurologic conditionsPharmacodynamic profileClinical indicationsDrug treatmentMood disordersEffective treatmentClozapineSubstance abuseChildhood schizophreniaRelevant literatureSchizophreniaDisordersTreatmentAggressive behaviorIndicationsInitial rationaleAgranulocytosisPatientsBody of literatureChronic neuroleptic exposure in bipolar outpatients.
Sernyak MJ, Godleski LS, Griffin RA, Mazure CM, Woods SW. Chronic neuroleptic exposure in bipolar outpatients. The Journal Of Clinical Psychiatry 1997, 58: 193-5. PMID: 9184612, DOI: 10.4088/jcp.v58n0503.Peer-Reviewed Original ResearchConceptsChronic neuroleptic exposureNeuroleptic exposureBipolar outpatientsBipolar disorderConnecticut Mental Health CenterChronic neuroleptic administrationMental health centersComputerized administrative databasesNeuroleptic medicationChlorpromazine equivalentsNeuroleptic administrationChronic useMedical recordsAdministrative databasesNeuroleptic dosageHealth centersBipolar patientsPatientsOutpatientsReview criteriaDisordersExposurePast yearMedicationsDiagnosisMagnetic resonance imaging-based measurement of hippocampal volume in posttraumatic stress disorder related to childhood physical and sexual abuse—a preliminary report
Bremner J, Randall P, Vermetten E, Staib L, Bronen R, Mazure C, Capelli S, McCarthy G, Innis R, Charney D. Magnetic resonance imaging-based measurement of hippocampal volume in posttraumatic stress disorder related to childhood physical and sexual abuse—a preliminary report. Biological Psychiatry 1997, 41: 23-32. PMID: 8988792, PMCID: PMC3229101, DOI: 10.1016/s0006-3223(96)00162-x.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderLeft hippocampal volumeHippocampal volumeChildhood abuseAdult survivorsSmaller left hippocampal volumeAbuse-related posttraumatic stress disorderStress disorderSmaller hippocampal volumesCombat-related posttraumatic stress disorderMagnetic resonance imagingShort-term memoryHealthy subjectsYears of educationAlcohol abuseMagnetic resonance imaging-based measurementsComparison subjectsPTSD patientsImaging-based measurementsResonance imagingPatientsSexual abusePreliminary reportSurvivorsComparison region
1996
Possible acceleration of alcoholic cirrhosis in a patient with bulimia
Platis I, Carpenter L, Vojvoda D, Bowers M, Mazure C. Possible acceleration of alcoholic cirrhosis in a patient with bulimia. International Journal Of Eating Disorders 1996, 20: 439-442. PMID: 8953333, DOI: 10.1002/(sici)1098-108x(199612)20:4<439::aid-eat13>3.0.co;2-t.Peer-Reviewed Original Research
1995
Desipramine Treatment of Major Depression in Patients Over 75 Years of Age
Nelson J, Mazure C, Jatlow P. Desipramine Treatment of Major Depression in Patients Over 75 Years of Age. Journal Of Clinical Psychopharmacology 1995, 15: 99-105.. PMID: 7782495, DOI: 10.1097/00004714-199504000-00004.Peer-Reviewed Original ResearchConceptsYounger patientsYears of ageElderly patientsMajor depressionDesipramine concentrationsDrug treatmentPatient trialsAdverse reaction rateMore effective drug treatmentsEffective drug treatmentUnipolar major depressionDesipramine treatmentDepressed patientsComparable dosesPatientsSide effectsResponse rateSimilar durationTrialsSecond trialTreatmentLower ratesBloodDepressionAge
1994
Serotonin function in aggression: The effect of acute plasma tryptophan depletion in aggressive patients
Salomon R, Mazure C, Delgado P, Mendia P, Charney D. Serotonin function in aggression: The effect of acute plasma tryptophan depletion in aggressive patients. Biological Psychiatry 1994, 35: 570-572. PMID: 8038301, DOI: 10.1016/0006-3223(94)90105-8.Peer-Reviewed Original ResearchCharacteristics of desipramine-refractory depression.
Nelson JC, Mazure CM, Jatlow PI. Characteristics of desipramine-refractory depression. The Journal Of Clinical Psychiatry 1994, 55: 12-9. PMID: 8294386.Peer-Reviewed Original ResearchConceptsDepressive episodePoor responseMajor depressionNonpsychotic unipolar major depressionPrior treatment failureAdequate blood levelsWeeks of hospitalizationDrug responseUnipolar major depressionRecurrence of depressionDefinite personality disorderDiagnosis of melancholiaConsecutive inpatientsDesipramine levelsTreatment failureBlood levelsGeneral HospitalInitial severityPlasma concentrationsDrug treatmentSecondary depressionDepression InventoryPatientsPersonality disorderDepression
1992
Valproate Treatment of Older Psychotic Patients with Organic Mental Syndromes and Behavioral Dyscontrol
Mazure CM, Druss BG, Cellar JS. Valproate Treatment of Older Psychotic Patients with Organic Mental Syndromes and Behavioral Dyscontrol. Journal Of The American Geriatrics Society 1992, 40: 914-916. PMID: 1512389, DOI: 10.1111/j.1532-5415.1992.tb01990.x.Peer-Reviewed Original ResearchDysarthria During ECT Given for Parkinson's Disease and Depression.
Holzer JC, Giakas WJ, Mazure CM, Price BH. Dysarthria During ECT Given for Parkinson's Disease and Depression. Journal Of Ect 1992, 8: 201-203. PMID: 11941170.Peer-Reviewed Original Research
1991
A Preliminary, Open Study of the Combination of Fluoxetine and Desipramine for Rapid Treatment of Major Depression
Nelson JC, Mazure CM, Bowers MB, Jatlow PI. A Preliminary, Open Study of the Combination of Fluoxetine and Desipramine for Rapid Treatment of Major Depression. JAMA Psychiatry 1991, 48: 303-307. PMID: 2009031, DOI: 10.1001/archpsyc.1991.01810280019002.Peer-Reviewed Original ResearchConceptsMajor depressionMean changeHamilton Depression Rating Scale scoresDepression Rating Scale scoresCombination of fluoxetineDesipramine plasma levelsRating Scale scoresBeta-adrenergic receptorsOpen studyDesipramine levelsPlasma levelsStandardized doseScale scoreDesipramineDesipramine hydrochlorideRapid treatmentPatientsFluoxetineDrugsWeeksDepressionInpatientsTreatmentRecent studiesSame setting
1990
Value of the DST for predicting response of patients with major depression to hospitalization and desipramine
Nelson JC, Mazure CM, Jatlow PI. Value of the DST for predicting response of patients with major depression to hospitalization and desipramine. American Journal Of Psychiatry 1990, 147: 1488-1492. PMID: 2221161, DOI: 10.1176/ajp.147.11.1488.Peer-Reviewed Original ResearchConceptsDexamethasone suppression testResponse of patientsMajor depressionNegative dexamethasone suppression testPositive dexamethasone suppression testWeeks of hospitalizationNonpsychotic major depressionPlasma levelsSuppression testRate of responseAntidepressant drugsDrug treatmentPatientsHospitalizationDesipraminePrior reportsDepressionResponsePrior studiesPlaceboFindingsTrialsWeeks