2022
Suspected cholinergic toxicity due to cevimeline hydrochloride and Bacopa monnieri interaction: a case report
Acquarulo B, Tandon P, Macica C. Suspected cholinergic toxicity due to cevimeline hydrochloride and Bacopa monnieri interaction: a case report. Journal Of Medical Case Reports 2022, 16: 253. PMID: 35765109, PMCID: PMC9241182, DOI: 10.1186/s13256-022-03479-4.Peer-Reviewed Original ResearchConceptsSjögren's syndromePossible drug-herb interactionsPrimary care officesDrug-herb interactionsST-T changesCevimeline hydrochlorideClinical improvementUndesirable side effectsUrinary retentionCase presentationACare officesCase reportCholinergic toxicityCaucasian femaleHerbal supplementsSide effectsClinical relevanceDrug responsivenessCommon genetic variantsSyndromeDrugsPrevious nightCytochrome P450Genetic variantsSupplementation interaction
2020
Osteoarthritis, Osteophytes, and Enthesophytes Affect Biomechanical Function in Adults With X-linked Hypophosphatemia
Steele A, Gonzalez R, Garbalosa JC, Steigbigel K, Grgurich T, Parisi EJ, Feinn RS, Tommasini SM, Macica CM. Osteoarthritis, Osteophytes, and Enthesophytes Affect Biomechanical Function in Adults With X-linked Hypophosphatemia. The Journal Of Clinical Endocrinology & Metabolism 2020, 105: dgaa064. PMID: 32047911, PMCID: PMC8416779, DOI: 10.1210/clinem/dgaa064.Peer-Reviewed Original ResearchConceptsMusculoskeletal comorbiditiesGait analysisPassive ROMLifelong metabolic diseaseWeight-bearing jointsHealth care teamDiagnosis of XLHInterprofessional health care teamsKinematic gait analysisMusculoskeletal manifestationsClinical presentationMusculoskeletal disabilityDegenerative arthritisPhysical functionRadiologic imagingCervical spineGoniometric rangeDaily livingFunctional limitationsTrunk swayMetabolic diseasesMusculoskeletal functionAnkle jointSynovial jointsXLH
2016
Novel anatomic adaptation of cortical bone to meet increased mineral demands of reproduction
Macica CM, King HE, Wang M, McEachon CL, Skinner CW, Tommasini SM. Novel anatomic adaptation of cortical bone to meet increased mineral demands of reproduction. Bone 2016, 85: 59-69. PMID: 26825813, PMCID: PMC7429445, DOI: 10.1016/j.bone.2015.12.056.Peer-Reviewed Original ResearchConceptsHyp miceMineral homeostasisElevated serum PTHMaternal bone massMineralized trabecular boneIntestinal calcium absorptionCortical boneWild-type miceSerum PTHCalcitriol productionFemale patientsMaternal skeletonPostnatal nutritionCalcium absorptionBone resorptionFracture riskMaternal adaptationBone massBone fragilityMurine modelIntracortical porosityUnaffected miceMouse modelMMP-13Fetal development
2012
Mineralizing Enthesopathy Is a Common Feature of Renal Phosphate-Wasting Disorders Attributed to FGF23 and Is Exacerbated by Standard Therapy in Hyp Mice
Karaplis A, Bai X, Falet J, Macica C. Mineralizing Enthesopathy Is a Common Feature of Renal Phosphate-Wasting Disorders Attributed to FGF23 and Is Exacerbated by Standard Therapy in Hyp Mice. Endocrinology 2012, 153: 5906-5917. PMID: 23038738, PMCID: PMC3512070, DOI: 10.1210/en.2012-1551.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsExtracellular Matrix ProteinsFamilial Hypophosphatemic RicketsFemaleFibroblast Growth Factor-23Fibroblast Growth FactorsGenetic Diseases, X-LinkedImmunohistochemistryKidneyMaleMiceMice, Inbred C57BLMice, TransgenicModels, GeneticMutationPedigreePhosphatesPhosphoproteinsRheumatic DiseasesTransgenesUp-RegulationConceptsPhosphate-wasting disordersStandard therapyFGF23 levelsElevated fibroblast growth factor 23Hyp miceRenal phosphate-wasting disordersFibroblast growth factor 23High FGF23 levelsGrowth factor 23Elevated FGF23 levelsAction of FGF23Dentin matrix acidic phosphoprotein 1Phosphate wasting disorderAutosomal recessive hypophosphatemic ricketsRecessive hypophosphatemic ricketsLigament insertion sitesChildhood managementOral phosphateFactor 23Achilles insertionDisease morbidityPotential morbidityBone spursUntoward effectsMurine model
2009
Survey of the Enthesopathy of X-Linked Hypophosphatemia and Its Characterization in Hyp Mice
Liang G, Katz LD, Insogna KL, Carpenter TO, Macica CM. Survey of the Enthesopathy of X-Linked Hypophosphatemia and Its Characterization in Hyp Mice. Calcified Tissue International 2009, 85: 235-246. PMID: 19609735, PMCID: PMC2988401, DOI: 10.1007/s00223-009-9270-6.Peer-Reviewed Original ResearchMeSH KeywordsAchilles TendonAdolescentAdultAgedAnimalsBiomarkersCalcinosisChildDisease Models, AnimalDisease ProgressionFamilial Hypophosphatemic RicketsFemaleFibroblast Growth Factor-23Fibroblast Growth FactorsGenetic Diseases, X-LinkedHumansMiceMice, Inbred C57BLMiddle AgedPatellar LigamentPhenotypeQuadriceps MuscleRadiographyRheumatic DiseasesTendinopathyTendonsYoung AdultConceptsFGF-23Fibroblast growth factor receptor 3Hyp miceMajority of patientsHigh circulating levelsPhosphate-regulating hormoneBone spur formationTendon insertion siteGrowth factor receptor 3Insertion siteLigament insertion sitesCirculating LevelsPhosphate excretionBone-forming osteoblastsHeterotopic calcificationOsteophyte formationHistological examinationMurine modelReceptor 3Spur formationHypophosphatemiaEnthesis fibrocartilageBone mineralizationBiochemical milieuMice
1998
Role of the NH2 terminus of the cloned renal K+ channel, ROMK1, in arachidonic acid-mediated inhibition
Macica C, Yang Y, Lerea K, Hebert S, Wang W. Role of the NH2 terminus of the cloned renal K+ channel, ROMK1, in arachidonic acid-mediated inhibition. American Journal Of Physiology 1998, 274: f175-f181. PMID: 9458837, DOI: 10.1152/ajprenal.1998.274.1.f175.Peer-Reviewed Original ResearchAlanineAmino Acid SequenceAmino Acid SubstitutionAnimalsArachidonic AcidCell LineCloning, MolecularFemaleIon Channel GatingMembrane PotentialsMolecular Sequence DataMutagenesis, Site-DirectedOocytesPotassium ChannelsPotassium Channels, Inwardly RectifyingProtein Kinase CRatsRecombinant ProteinsSequence AlignmentSerineTransfectionXenopus laevis
1996
Arachidonic acid inhibits activity of cloned renal K+ channel, ROMK1
Macica CM, Yang Y, Hebert SC, Wang WH. Arachidonic acid inhibits activity of cloned renal K+ channel, ROMK1. American Journal Of Physiology 1996, 271: f588-f594. PMID: 8853420, DOI: 10.1152/ajprenal.1996.271.3.f588.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsArachidonic AcidCaffeic AcidsCloning, MolecularCyclooxygenase InhibitorsCytochrome P-450 Enzyme InhibitorsFatty AcidsFatty Acids, UnsaturatedFemaleIndomethacinKidney MedullaKineticsLipoxygenase InhibitorsOocytesPatch-Clamp TechniquesPotassium Channel BlockersPotassium ChannelsRatsXenopus laevis
1994
Endothelin-1 conversion and receptor characterization in human placental arteries
Wilkes B, Macica C, Mento P. Endothelin-1 conversion and receptor characterization in human placental arteries. American Journal Of Physiology 1994, 267: e242-e249. PMID: 8074203, DOI: 10.1152/ajpendo.1994.267.2.e242.Peer-Reviewed Original ResearchConceptsFetoplacental blood vesselsEndothelin-1Big endothelin-1Blood vesselsHuman placental arteriesEndothelin receptor subtypesEndothelin-1 receptorsAtrial natriuretic factorTime-dependent increasePlacental arteriesSpecific receptor sitesPerfusion pressureAngiotensin IIEndothelin receptorsNatriuretic factorReceptor subtypesSmall arteriesPlacental cotyledonsPotency orderFmol/High-affinity binding sitesBig endothelinReceptor characterizationScatchard analysisPressor peptide