2008
A Serpin that Regulates Immune Melanization in the Respiratory System of Drosophila
Tang H, Kambris Z, Lemaitre B, Hashimoto C. A Serpin that Regulates Immune Melanization in the Respiratory System of Drosophila. Developmental Cell 2008, 15: 617-626. PMID: 18854145, PMCID: PMC2671232, DOI: 10.1016/j.devcel.2008.08.017.Peer-Reviewed Original ResearchConceptsAntifungal peptide drosomycinInternal tissuesToll pathwayChemical defensesProtease cascadeMelanin biosynthesisMelanization reactionKey enzymeSerpin familyDrosophilaMelanizationPresence of microorganismsEpithelial tissuesMicrobial infectionsPhenol oxidaseHost defenseSystemic expressionEpithelial defenseProtease inhibitorsDefensePhysical barrierPathogensDrosomycinBiosynthesisTissue
2006
Two Proteases Defining a Melanization Cascade in the Immune System of Drosophila *
Tang H, Kambris Z, Lemaitre B, Hashimoto C. Two Proteases Defining a Melanization Cascade in the Immune System of Drosophila *. Journal Of Biological Chemistry 2006, 281: 28097-28104. PMID: 16861233, DOI: 10.1074/jbc.m601642200.Peer-Reviewed Original ResearchConceptsMelanization cascadeMelanization reactionResistance of DrosophilaDownstream proteasesDrosophilaKey enzymeMicrobial pathogensGenetic characterizationMelanin synthesisSerine proteasesMelanizationProteasePathogenic bacteriaMicrobial infectionsMP1PhenoloxidaseFungal infectionsCascadeImportant roleImmune systemSpn27AArthropodsFungiEnzymeBacteria