2023
Assessment of children's personal and land use regression model-estimated exposure to NO2 in Springfield, Massachusetts
Gao D, Esenther S, Minet L, De Jesus A, Hudson S, Leaderer B, Hatzopoulou M, Godri Pollitt K. Assessment of children's personal and land use regression model-estimated exposure to NO2 in Springfield, Massachusetts. The Science Of The Total Environment 2023, 892: 164681. PMID: 37302586, DOI: 10.1016/j.scitotenv.2023.164681.Peer-Reviewed Original Research
2022
Childhood asthma and household exposures to nitrogen dioxide and fine particles: a triple-crossover randomized intervention trial
Gent JF, Holford TR, Bracken MB, Plano JM, McKay LA, Sorrentino KM, Koutrakis P, Leaderer BP. Childhood asthma and household exposures to nitrogen dioxide and fine particles: a triple-crossover randomized intervention trial. Journal Of Asthma 2022, 60: 744-753. PMID: 35796019, PMCID: PMC10162040, DOI: 10.1080/02770903.2022.2093219.Peer-Reviewed Original ResearchMeSH KeywordsAir PollutantsAir Pollution, IndoorAsthmaChildHousehold ProductsHumansMassachusettsNitrogen DioxideParticulate MatterConceptsLevels of NOPersistent asthmaAsthma symptomsIntervention trialsNumber of asthmaDays of treatmentSymptom daysAsthma morbidityChildhood asthmaTreatment periodAsthmaCrossover designHousehold exposureSymptomsModest reductionTreatment effectsTreatmentGas stovesTrialsExposureTriple crossoverInterventionChildrenMixed modelsFurther research
2017
Traffic‐related air pollution associations with cytokeratin‐18, a marker of hepatocellular apoptosis, in an overweight and obese paediatric population
Hsieh S, Leaderer BP, Feldstein AE, Santoro N, McKay LA, Caprio S, McConnell R. Traffic‐related air pollution associations with cytokeratin‐18, a marker of hepatocellular apoptosis, in an overweight and obese paediatric population. Pediatric Obesity 2017, 13: 342-347. PMID: 28730729, PMCID: PMC5775922, DOI: 10.1111/ijpo.12228.Peer-Reviewed Original ResearchConceptsNon-alcoholic fatty liver diseaseTraffic-related air pollutionNon-alcoholic steatohepatitisHepatic fat fractionCK-18Pre-existing non-alcoholic fatty liver diseaseCytokeratin 18Fatty liver diseaseObese pediatric populationPediatric obesity clinicNitrogen dioxide exposureMagnetic resonance imagingObesity clinicStudy entryFatty liverLiver diseaseObese childrenPediatric populationLiver enzymesLiver susceptibilityHepatocellular apoptosisAnimal modelsResidential buffersResonance imagingAir pollution associations
2016
Unconventional oil and gas development and risk of childhood leukemia: Assessing the evidence
Elliott EG, Trinh P, Ma X, Leaderer BP, Ward MH, Deziel NC. Unconventional oil and gas development and risk of childhood leukemia: Assessing the evidence. The Science Of The Total Environment 2016, 576: 138-147. PMID: 27783932, PMCID: PMC6457992, DOI: 10.1016/j.scitotenv.2016.10.072.Peer-Reviewed Original ResearchMeSH KeywordsAir PollutantsChildEnvironmental MonitoringHumansLeukemiaOil and Gas FieldsPolycyclic Aromatic HydrocarbonsUnited StatesConceptsWater contaminantsPotential water contaminantsMajority of compoundsWater pollutantsPolycyclic aromatic hydrocarbonsHydraulic fracturing fluidsPollutantsAromatic hydrocarbonsAir pollutantsU.S. Environmental Protection AgencyCompoundsEnvironmental Protection AgencyPotential air pollutantsPossible human carcinogenContaminantsChemicalsCarcinogenicity of compoundsLeukemia/lymphomaProtection AgencyChildhood leukemiaWaterButadieneBenzeneFracturing fluidOilSpatiotemporal calibration and resolution refinement of output from deterministic models
Gilani O, McKay LA, Gregoire TG, Guan Y, Leaderer BP, Holford TR. Spatiotemporal calibration and resolution refinement of output from deterministic models. Statistics In Medicine 2016, 35: 2422-2440. PMID: 26790617, DOI: 10.1002/sim.6867.Peer-Reviewed Original ResearchConceptsGrid-cell formatCurrent calibration techniquesSpatiotemporal calibrationModeling strategyCommunity Multiscale Air Quality (CMAQ) modelAir quality modelsMultiscale Air Quality modelCalibration techniqueObserved measurementsPixel sizeSpatial resolutionGrid dataMonitoring stationsQuality modelDeterministic modelRegular gridAmbient nitrogen dioxide concentrationsDaily estimatesMeasurementsProcess of interestGridNitrogen dioxide concentrationsProcessPixelsDioxide concentrationHousehold concentrations and personal exposure of PM2.5 among urban residents using different cooking fuels
Li T, Cao S, Fan D, Zhang Y, Wang B, Zhao X, Leaderer BP, Shen G, Zhang Y, Duan X. Household concentrations and personal exposure of PM2.5 among urban residents using different cooking fuels. The Science Of The Total Environment 2016, 548: 6-12. PMID: 26799802, PMCID: PMC4760902, DOI: 10.1016/j.scitotenv.2016.01.038.Peer-Reviewed Original ResearchConceptsInhalation exposure levelsExposure levelsEnvironmental risk factorsTotal PM2.5 exposuresDifferent cooking fuelsDifferent age groupsRisk factorsPM2.5 exposureAge groupsPremature deathHousehold concentrationsPersonal exposureIndoor combustion sourcesHigher indoor concentrationsCooking fuelExposureOutdoor PM2.5 concentrationsNon-heating seasonLevelsIndoor concentrationsDisease
2012
Relationship between birth weight and exposure to airborne fine particulate potassium and titanium during gestation
Bell ML, Belanger K, Ebisu K, Gent JF, Leaderer BP. Relationship between birth weight and exposure to airborne fine particulate potassium and titanium during gestation. Environmental Research 2012, 117: 83-89. PMID: 22705336, PMCID: PMC3418490, DOI: 10.1016/j.envres.2012.05.004.Peer-Reviewed Original ResearchConceptsLow birth weightBirth weightAdverse pregnancy outcomesPregnancy outcomesTerm infantsAirborne fine particulate matterStudy populationIQR increaseMothers' exposureAfrican American mothersFirst birthInfantsEffect estimatesConfidence intervalsWhite mothersPregnancyHealth impactsRiskExposureFine particulate matterMothersMost studiesGestationWeight
2011
Spatial and temporal variability of fine particle composition and source types in five cities of Connecticut and Massachusetts
Lee HJ, Gent JF, Leaderer BP, Koutrakis P. Spatial and temporal variability of fine particle composition and source types in five cities of Connecticut and Massachusetts. The Science Of The Total Environment 2011, 409: 2133-2142. PMID: 21429560, PMCID: PMC3269973, DOI: 10.1016/j.scitotenv.2011.02.025.Peer-Reviewed Original ResearchConceptsPositive matrix factorizationSource contributionsSource typesTemporal variabilityRegional pollutionSource apportionment modelingLess spatial variabilityFine particle compositionRegional average concentrationsSea saltSpatial variabilityRegional averagePMF analysisMonitoring sitesOil combustionParticle compositionRoad dustAverage concentrationSite correlationsVariability
2010
Prenatal Exposure to Fine Particulate Matter and Birth Weight
Bell ML, Belanger K, Ebisu K, Gent JF, Lee HJ, Koutrakis P, Leaderer BP. Prenatal Exposure to Fine Particulate Matter and Birth Weight. Epidemiology 2010, 21: 884-891. PMID: 20811286, PMCID: PMC3055585, DOI: 10.1097/ede.0b013e3181f2f405.Peer-Reviewed Original Research
2009
Integrated exposure modeling: A model using GIS and GLM
Holford TR, Ebisu K, McKay LA, Gent JF, Triche EW, Bracken MB, Leaderer BP. Integrated exposure modeling: A model using GIS and GLM. Statistics In Medicine 2009, 29: 116-129. PMID: 19823976, PMCID: PMC3182125, DOI: 10.1002/sim.3732.Peer-Reviewed Original ResearchConceptsGeneralized linear modelLinear modelLayout of roadsDispersion functionStatistical modelStandard regression techniquesTraffic-related health effectsSecond examplePollutant dispersionSpline modelSpatial modelRegression techniquesDaily trafficConnecticut homesIntegralsModelTraffic densityDispersionGLMTrafficVariablesFunctionMeteorologyTraffic-related pollution
2000
Model for the Analysis of Binary Time Series of Respiratory Symptoms
Zhang H, Triche E, Leaderer B. Model for the Analysis of Binary Time Series of Respiratory Symptoms. American Journal Of Epidemiology 2000, 151: 1206-1215. PMID: 10905533, DOI: 10.1093/oxfordjournals.aje.a010171.Peer-Reviewed Original ResearchConceptsDuration of symptomsRespiratory symptomsNew episodesStuffy nosePrior historyHistory of allergyDaily respiratory symptomsInfant Health StudyMeteorologic changesHealth StudySymptomsEpidemiologic researchDay careMarital statusIncidenceEnvironmental epidemiologic researchEpisodesMothersDurationSulfate levelsHusband's levelDemographic variablesNoseHigh levelsAllergy
1999
Healthy Women's PEF Variations with Ambient Summer Concentrations of PM10, PM2.5, SO4 2 −, H+, and O3
NAEHER L, HOLFORD T, BECKETT W, BELANGER K, TRICHE E, BRACKEN M, LEADERER B. Healthy Women's PEF Variations with Ambient Summer Concentrations of PM10, PM2.5, SO4 2 −, H+, and O3. American Journal Of Respiratory And Critical Care Medicine 1999, 160: 117-125. PMID: 10390388, DOI: 10.1164/ajrccm.160.1.9808153.Peer-Reviewed Original ResearchConceptsPeak expiratory flowPEF variationEvening peak expiratory flowMorning peak expiratory flowOutdoor monitoring sitePeak flow meterAmbient air pollutionMicrograms/m3Expiratory flowPhysiologic effectsPEF measurementsOnly exposureConcurrent measuresExposureMeteorologic variablesFine particulate sulfateDailyIndoor, outdoor, and regional summer and winter concentrations of PM10, PM2.5, SO4(2)-, H+, NH4+, NO3-, NH3, and nitrous acid in homes with and without kerosene space heaters.
Leaderer B, Naeher L, Jankun T, Balenger K, Holford T, Toth C, Sullivan J, Wolfson J, Koutrakis P. Indoor, outdoor, and regional summer and winter concentrations of PM10, PM2.5, SO4(2)-, H+, NH4+, NO3-, NH3, and nitrous acid in homes with and without kerosene space heaters. Environmental Health Perspectives 1999, 107: 223-231. PMID: 10064553, PMCID: PMC1566377, DOI: 10.1289/ehp.99107223.Peer-Reviewed Original Research
1993
Assessing exposures to inhaled complex mixtures.
Leaderer B, Lioy P, Spengler J. Assessing exposures to inhaled complex mixtures. Environmental Health Perspectives 1993, 101: 167-177. PMID: 8206025, PMCID: PMC1519694, DOI: 10.1289/ehp.93101s4167.Peer-Reviewed Original Research
1986
A Study of Respiratory Effects from Exposure to 2 ppm Formaldehyde in Healthy Subjects
Schachter E, Witek T, Tosun T, Leaderer B, Beck G. A Study of Respiratory Effects from Exposure to 2 ppm Formaldehyde in Healthy Subjects. Archives Of Environmental & Occupational Health 1986, 41: 229-239. PMID: 3767432, DOI: 10.1080/00039896.1986.9938338.Peer-Reviewed Original ResearchConceptsHealthy subjectsUpper airwaySeparate daysMaximal flow-volume curvesLower airway symptomsFlow-volume curvesAirway responsesAirway symptomsPulmonary functionRespiratory symptomsSignificant bronchoconstrictionLung functionSymptom diaryAirway resistanceIrritative phenomenaModerate exercisePhysiologic alterationsRespiratory effectsSubjective complaintsBaseline responsivenessFA exposureHealthy individualsIrritative propertiesRespiratory systemSuch exposureASSESSMENT OF EXPOSURE TO INDOOR AIR CONTAMINANTS FROM COMBUSTION SOURCES: METHODOLOGY AND APPLICATION
LEADERER B, ZAGRANISKI R, BERWICK M, STOLWIJK J. ASSESSMENT OF EXPOSURE TO INDOOR AIR CONTAMINANTS FROM COMBUSTION SOURCES: METHODOLOGY AND APPLICATION. American Journal Of Epidemiology 1986, 124: 275-289. PMID: 3088984, DOI: 10.1093/oxfordjournals.aje.a114386.Peer-Reviewed Original ResearchConceptsAcute respiratory illnessIndoor air pollutant exposuresPersonal NO2 exposuresAir pollutant exposureIndoor NO2 levelsUnvented kerosene space heatersTobacco smokersIndoor air contaminant levelsRespiratory illnessAssessment of exposureIndoor NO2Health effectsEnvironmental exposuresLevels of NO2Unvented combustionNO2 exposureExposure assessmentNational health standardsGas cooking stovesKerosene space heatersPollutant exposureNO2 levelsKerosene heatersExcellent predictorExposure
1979
Ambient sulfates, photochemical oxidants, and acute adverse health effects: An epidemiological study
Zagraniski R, Leaderer B, Stolwijk J. Ambient sulfates, photochemical oxidants, and acute adverse health effects: An epidemiological study. Environmental Research 1979, 19: 306-320. PMID: 315309, DOI: 10.1016/0013-9351(79)90058-6.Peer-Reviewed Original ResearchConceptsAcute adverse health effectsAdverse health effectsHealth effectsTelephone company employeesAsthma clinicChronic bronchitisGroups of subjectsHeavy smokersAcute symptomsSymptom ratesHay feverThroat irritationEpidemiological studiesMore symptomsSuch illnessesEye irritationSusceptible peopleConnecticut areaSmokersIllnessSymptomsIrritationOxidant levelsGroupNew Haven
1978
Summary of the New York Summer Aerosol Study (Nysas)
Leaderer B, Bernstein D, Daisey J, Kleinman M, Kneip T, Knutson E, Lippmann M, Lioy P, Rahn K, Sinclair D, Tanner R, Wolff G. Summary of the New York Summer Aerosol Study (Nysas). Journal Of The Air & Waste Management Association 1978, 28: 321-327. PMID: 670583, DOI: 10.1080/00022470.1978.10470604.Peer-Reviewed Original Research