2013
Mislocalization of neuronal mitochondria reveals regulation of Wallerian degeneration and NMNAT/WLDS-mediated axon protection independent of axonal mitochondria
Kitay BM, McCormack R, Wang Y, Tsoulfas P, Zhai RG. Mislocalization of neuronal mitochondria reveals regulation of Wallerian degeneration and NMNAT/WLDS-mediated axon protection independent of axonal mitochondria. Human Molecular Genetics 2013, 22: 1601-1614. PMID: 23314018, PMCID: PMC3657477, DOI: 10.1093/hmg/ddt009.Peer-Reviewed Original ResearchConceptsDrosophila larval motor neuronsLarval motor neuronsAxonal mitochondriaRole of mitochondriaEvolutionary conservationMN axonsMorphological comparisonMotor neuronsMitochondriaMolecular pathwaysAxon protectionNeuronal mitochondriaWallerian degenerationNeurodegenerative diseasesCentral roleIntense investigationDistal axonsRegulationMorphological changesDorsal root ganglion explantsAxon degenerationHuman DRG neuronsCritical sitesUnderlying mechanismMislocalization
2007
Schwann Cell Transplantation Improves Reticulospinal Axon Growth and Forelimb Strength after Severe Cervical Spinal Cord Contusion
Schaal SM, Kitay BM, Cho KS, Lo TP, Barakat DJ, Marcillo AE, Sanchez AR, Andrade CM, Pearse DD. Schwann Cell Transplantation Improves Reticulospinal Axon Growth and Forelimb Strength after Severe Cervical Spinal Cord Contusion. Cell Transplantation 2007, 16: 207-228. PMID: 17503734, DOI: 10.3727/000000007783464768.Peer-Reviewed Original ResearchConceptsSpinal cord injuryAxon growthNeuroprotective efficacyCervical spinal cord contusionInjury/graft siteCell bodiesThoracic spinal cord injurySchwann cell transplantationSpinal cord contusionThoracic spinal cordAdult female Fischer ratsFemale Fischer ratsSchwann cell implantationUpper limb strengthSignificant behavioral improvementCervical contusionInjury epicenterCord contusionUpper body strengthWeeks postinjuryBBB scoresSC implantsSupraspinal axonsCell transplantationCord injury