Featured Publications
Exploring the Big Data Paradox for various estimands using vaccination data from the global COVID-19 Trends and Impact Survey (CTIS)
Yang Y, Dempsey W, Han P, Deshmukh Y, Richardson S, Tom B, Mukherjee B. Exploring the Big Data Paradox for various estimands using vaccination data from the global COVID-19 Trends and Impact Survey (CTIS). Science Advances 2024, 10: eadj0266. PMID: 38820165, PMCID: PMC11314312, DOI: 10.1126/sciadv.adj0266.Peer-Reviewed Original ResearchAssociation of Polygenic Risk Scores for Multiple Cancers in a Phenome-wide Study: Results from The Michigan Genomics Initiative
Fritsche L, Gruber S, Wu Z, Schmidt E, Zawistowski M, Moser S, Blanc V, Brummett C, Kheterpal S, Abecasis G, Mukherjee B. Association of Polygenic Risk Scores for Multiple Cancers in a Phenome-wide Study: Results from The Michigan Genomics Initiative. American Journal Of Human Genetics 2018, 102: 1048-1061. PMID: 29779563, PMCID: PMC5992124, DOI: 10.1016/j.ajhg.2018.04.001.Peer-Reviewed Original ResearchConceptsPolygenic risk scoresElectronic health recordsAssociations of polygenic risk scoresPhenome-wide significant associationsPolygenic risk score associationsLongitudinal biorepository effortNon-cancer diagnosesPatients' electronic health recordsPhenome-wide association studyAnalysis of temporal orderMichigan Genomics InitiativeRisk scoreAssociated with multiple phenotypesFemale breast cancerNHGRI-EBI CatalogRisk profileGenetic risk profilesMeasures of genomic variationCancer traitsCase-control studyPheWAS analysisHealth recordsHealth systemMichigan MedicineCancer diagnosisCharacteristics Associated With Racial/Ethnic Disparities in COVID-19 Outcomes in an Academic Health Care System
Gu T, Mack J, Salvatore M, Sankar S, Valley T, Singh K, Nallamothu B, Kheterpal S, Lisabeth L, Fritsche L, Mukherjee B. Characteristics Associated With Racial/Ethnic Disparities in COVID-19 Outcomes in an Academic Health Care System. JAMA Network Open 2020, 3: e2025197. PMID: 33084902, PMCID: PMC7578774, DOI: 10.1001/jamanetworkopen.2020.25197.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBetacoronavirusBlack or African AmericanComorbidityCoronavirus InfectionsCOVID-19Diabetes Mellitus, Type 2FemaleHealth Status DisparitiesHospitalizationHumansIntensive Care UnitsKidney DiseasesMaleMichiganMiddle AgedNeoplasmsObesityOdds RatioPandemicsPneumonia, ViralPopulation DensityRetrospective StudiesRisk FactorsSARS-CoV-2White PeopleConceptsAssociated with higher riskInternational Classification of DiseasesRisk of hospitalizationPreexisting type 2 diabetesHigher risk of hospitalizationClassification of DiseasesType 2 diabetesCOVID-19 outcomesRacial/ethnic disparitiesWhite patientsBlack patientsIntensive care unitInternational ClassificationResidential-level socioeconomic characteristicsOdds ratioStatistically significant racial differencesHigh riskAssociated with higher risk of hospitalizationNon-Hispanic blacksAssociation of risk factorsNon-Hispanic whitesMichigan Department of HealthAssociated with increased risk of hospitalizationComorbidity scoreDepartment of HealthRisk of Non-Melanoma Cancers in First-Degree Relatives of CDKN2A Mutation Carriers
Mukherjee B, DeLancey J, Raskin L, Everett J, Jeter J, Begg C, Orlow I, Berwick M, Armstrong B, Kricker A, Marrett L, Millikan R, Culver H, Rosso S, Zanetti R, Kanetsky P, From L, Gruber S, Investigators F. Risk of Non-Melanoma Cancers in First-Degree Relatives of CDKN2A Mutation Carriers. Journal Of The National Cancer Institute 2012, 104: 953-956. PMID: 22534780, PMCID: PMC3379723, DOI: 10.1093/jnci/djs221.Peer-Reviewed Original ResearchConceptsFirst-degree relatives of carriersCDKN2A mutation carriersFirst-degree relativesMutation carriersNon-melanoma cancersFirst-degree relatives of melanoma patientsFirst-degree relatives of mutation carriersKin-cohort methodConfidence intervalsRisk of cancerMelanoma patientsLifetime riskProband's genotypeNon-melanomaFamily membersIncreased riskGastrointestinal cancerCDKN2A mutationsWilms tumorRiskMelanoma StudyPancreatic cancerNoncarriersGenotype distributionMelanoma
2024
Cross-shift changes in pulmonary function and occupational exposure to particulate matter among e-waste workers in Ghana
Laskaris Z, O'Neill M, Batterman S, Mukherjee B, Fobil J, Robins T. Cross-shift changes in pulmonary function and occupational exposure to particulate matter among e-waste workers in Ghana. Frontiers In Public Health 2024, 12: 1368112. PMID: 38784567, PMCID: PMC11111984, DOI: 10.3389/fpubh.2024.1368112.Peer-Reviewed Original ResearchConceptsE-waste workersExposure to particulate matterE-wasteParticulate matterAgbogbloshie e-waste siteInhalation exposure to particulate matterE-waste sitesBurning e-wasteConcentrations of PMHealth-based guidelinesExposure to airborne pollutantsExposure to PMOccupational exposure to particulate matterCross-shift changesElectronic-wasteForced vital capacityPersonal PMPM exposureAirborne pollutantsLinear mixed modelsBreathing zone concentrationsPulmonary functionComparison populationRecovery workersMixed modelsAvocational exposure associations with ALS risk, survival, and phenotype: A Michigan-based case-control study
Goutman S, Boss J, Jang D, Piecuch C, Farid H, Batra M, Mukherjee B, Feldman E, Batterman S. Avocational exposure associations with ALS risk, survival, and phenotype: A Michigan-based case-control study. Journal Of The Neurological Sciences 2024, 457: 122899. PMID: 38278093, PMCID: PMC11060628, DOI: 10.1016/j.jns.2024.122899.Peer-Reviewed Original ResearchConceptsALS riskLower educational attainmentAssociated with ALS riskCase-control studyExercise 5Onset ageSelf-completionExposure variablesYard workExposure associationsRecreational danceIdentified exposureExerciseEducational attainmentAL burdenEnvironmental exposuresParticipantsAL factorPersonal participationAvocational exposureRiskExposomeHobbiesALS onsetComparison correction
2023
Cohort profile: Epidemiologic Questionnaire (EPI-Q) – a scalable, app-based health survey linked to electronic health record and genotype data
Salvatore M, Clark-Boucher D, Fritsche L, Ortlieb J, Houghtby J, Driscoll A, Caldwell-Larkins B, Smith J, Brummett C, Kheterpal S, Lisabeth L, Mukherjee B. Cohort profile: Epidemiologic Questionnaire (EPI-Q) – a scalable, app-based health survey linked to electronic health record and genotype data. Epidemiology And Health 2023, 45: e2023074. PMID: 37591787, PMCID: PMC10867525, DOI: 10.4178/epih.e2023074.Peer-Reviewed Original ResearchConceptsElectronic health recordsHealth recordsSelf-reported health dataFamily health historyEpidemiological questionnaireCancer screeningHealth cohortHealth SurveyHealth historyFinancial toxicityBaseline surveyEHR dataHealth dataCohort dataEPI-QAverage ageOccupational exposureGenotype dataParticipantsGenotype informationInstitutional review board approvalResponse rateCohortLife meaningQuestionnaire
2022
Psychosocial Stress and Hypothalamic-Pituitary-Adrenal Axis Stress Reactivity: Variations by Race and Socioeconomic Status Among Adults at Risk of Diabetes
Kalesnikava V, Clarke P, Mukherjee B, Sen S, Mezuk B. Psychosocial Stress and Hypothalamic-Pituitary-Adrenal Axis Stress Reactivity: Variations by Race and Socioeconomic Status Among Adults at Risk of Diabetes. Psychosomatic Medicine 2022, 84: 813-821. PMID: 35980779, DOI: 10.1097/psy.0000000000001112.Peer-Reviewed Original ResearchConceptsDomain-specific stressMeasures of psychosocial stressTrier Social Stress TestAssociated with cortisol recoveryHypothalamic-pituitary-adrenal axis reactivityPsychosocial stressPerceived stressEvidence of effect modificationCortisol responseHigh-SES neighborhoodsHigher perceived stressPsychosocial stress measuresSocioeconomically diverse cohortCortisol recoveryRisk of diabetesAssociated with cortisol responseNeighborhood SESHealth disparitiesEffect modificationNeurobiological stress responseSocioeconomic statusSocial Stress TestSelf-report measuresType 2 diabetesSalivary cortisol responseRace-specific associations of urinary phenols and parabens with adipokines in midlife women: The Study of Women's Health Across the Nation (SWAN)
Lee S, Karvonen-Gutierrez C, Mukherjee B, Herman W, Park S. Race-specific associations of urinary phenols and parabens with adipokines in midlife women: The Study of Women's Health Across the Nation (SWAN). Environmental Pollution 2022, 303: 119164. PMID: 35306088, PMCID: PMC9883839, DOI: 10.1016/j.envpol.2022.119164.Peer-Reviewed Original ResearchConceptsStudy of Women's HealthBayesian kernel machine regressionWomen's HealthLeptin levelsBlack womenAssociated with lower leptinAssociated with favorable profilesAsian womenSoluble leptin receptorRacial differencesRace-specific associationsUrinary phenolCross-sectional associationsNo significant associationObesity-related metabolic diseasesLog-transformed levelsSOB-RKernel machine regressionSerum adipokinesMetabolic disease burdenEffect modificationNation Multi-Pollutant StudyLow leptinLeptin receptorLinear regression modelsHigh pre-diagnosis inflammation-related risk score associated with decreased ovarian cancer survival
Brieger KK, Phung MT, Mukherjee B, Bakulski KM, Anton-Culver H, Bandera EV, Bowtell DDL, Cramer DW, DeFazio A, Doherty JA, Fereday S, Fortner RT, Gentry-Maharaj A, Goode EL, Goodman MT, Harris HR, Matsuo K, Menon U, Modugno F, Moysich KB, Qin B, Ramus SJ, Risch HA, Rossing MA, Schildkraut JM, Trabert B, Vierkant RA, Winham SJ, Wentzensen N, Wu AH, Ziogas A, Khoja L, Cho KR, McLean K, Richardson J, Grout B, Chase A, Deurloo CM, Odunsi K, Nelson BH, Brenton JD, Terry KL, Pharaoh P, Berchuck A, Hanley GE, Webb PM, Pike MC, Pearce CL. High pre-diagnosis inflammation-related risk score associated with decreased ovarian cancer survival. Cancer Epidemiology Biomarkers & Prevention 2022, 31: cebp.epi-21-0977-a.2021. PMID: 34789471, PMCID: PMC9281656, DOI: 10.1158/1055-9965.epi-21-0977.Peer-Reviewed Original ResearchConceptsOvarian cancer survivalCox proportional hazards modelProportional hazards modelCancer survivalOvarian cancerRisk scoreHazards modelNonsteroidal anti-inflammatory drug useAnti-inflammatory drug useMenopausal hormone therapy useEnvironmental tobacco smoke exposureInvasive epithelial ovarian cancerHormone therapy usePelvic inflammatory diseaseInflammation-related factorsPolycystic ovarian syndromeTobacco smoke exposureBody mass indexRisk of deathEpithelial ovarian cancerOvarian Cancer Association ConsortiumOvarian cancer diagnosisHigh death rateAspirin useOvarian syndrome
2021
Exposure to Primary Air Pollutants Generated by Highway Traffic and Daily Mortality Risk in Near-Road Communities: A Case-Crossover Study
Filigrana P, Milando C, Batterman S, Levy J, Mukherjee B, Pedde M, Szpiro A, Adar S. Exposure to Primary Air Pollutants Generated by Highway Traffic and Daily Mortality Risk in Near-Road Communities: A Case-Crossover Study. American Journal Of Epidemiology 2021, 191: 63-74. PMID: 34347034, DOI: 10.1093/aje/kwab215.Peer-Reviewed Original ResearchConceptsNear-road populationsAir pollutionMortality riskExposure to traffic-related air pollutionAverage PM2.5 exposureTraffic-generated air pollutionNear-road communitiesResearch LINE sourceConcentrations of PM2.5Traffic-related air pollutionCase-crossover designPrimary air pollutantsConditional logistic regressionPuget Sound area of Washington StateDaily mortality riskCase-crossoverTime-varying covariatesCerebrovascular mortalityPM2.5 exposurePrimary pollutantsQuantify associationsAerodynamic diameterShorter averaging periodsPM2.5PollutionPer- and Polyfluoroalkyl Substances and Hormone Levels During the Menopausal Transition
Harlow S, Hood M, Ding N, Mukherjee B, Calafat A, Randolph J, Gold E, Park S. Per- and Polyfluoroalkyl Substances and Hormone Levels During the Menopausal Transition. The Journal Of Clinical Endocrinology & Metabolism 2021, 106: e4427-e4437. PMID: 34181018, PMCID: PMC8677593, DOI: 10.1210/clinem/dgab476.Peer-Reviewed Original ResearchConceptsMidlife womenSex hormone-binding globulinFollicle-stimulating hormoneInverse associationStudy of Women's HealthPositive associationMenopausal transitionBody mass indexReproductive ageWomen's HealthSignificant linear trendNo significant associationNulliparous womenLinear mixed modelsSmoking statusYears of ageMass indexHormone-binding globulinMenopausal statusLongitudinal serum concentrationsSignificant associationSerum PFAS concentrationsMidlifeWomenPolyfluoroalkyl substancesUrinary Heavy Metals and Longitudinal Changes in Blood Pressure in Midlife Women: The Study of Women’s Health Across the Nation
Wang X, Karvonen-Gutierrez C, Herman W, Mukherjee B, Harlow S, Park S. Urinary Heavy Metals and Longitudinal Changes in Blood Pressure in Midlife Women: The Study of Women’s Health Across the Nation. Hypertension 2021, 78: 543-551. PMID: 34148361, PMCID: PMC8266752, DOI: 10.1161/hypertensionaha.121.17295.Peer-Reviewed Original ResearchPerfluoroalkyl and polyfluoroalkyl substances and body size and composition trajectories in midlife women: the study of women’s health across the nation 1999–2018
Ding N, Karvonen-Gutierrez C, Herman W, Calafat A, Mukherjee B, Park S. Perfluoroalkyl and polyfluoroalkyl substances and body size and composition trajectories in midlife women: the study of women’s health across the nation 1999–2018. International Journal Of Obesity 2021, 45: 1937-1948. PMID: 33986457, PMCID: PMC8384652, DOI: 10.1038/s41366-021-00848-9.Peer-Reviewed Original ResearchConceptsWaist circumferenceMidlife womenFat massLowest tertileAssociated with greater body sizeStudy of women's healthResultsAfter multivariable adjustmentAssociated with accelerated increaseTrajectories of weightAssociated with weightSubjects/MethodsThis studyWomen's HealthObesity riskFollow-upDual-energy X-ray absorptiometryLinear mixed modelsHighest tertileX-ray absorptiometryGreater body sizeMultivariable adjustmentBody fatEpidemiological evidenceNo significant resultsBody compositionAverage follow-upDepot-Medroxyprogesterone Acetate Use Is Associated with Decreased Risk of Ovarian Cancer: The Mounting Evidence of a Protective Role of ProgestinsDMPA Use Decreases Ovarian Cancer Risk
Phung M, Lee A, Wu A, Berchuck A, Cho K, Cramer D, Doherty J, Goodman M, Hanley G, Harris H, McLean K, Modugno F, Moysich K, Mukherjee B, Schildkraut J, Terry K, Titus L, Consortium O, Jordan S, Webb P, Consortium O, Pike M, Pearce C. Depot-Medroxyprogesterone Acetate Use Is Associated with Decreased Risk of Ovarian Cancer: The Mounting Evidence of a Protective Role of ProgestinsDMPA Use Decreases Ovarian Cancer Risk. Cancer Epidemiology Biomarkers & Prevention 2021, 30: 927-935. PMID: 33619020, PMCID: PMC9281627, DOI: 10.1158/1055-9965.epi-20-1355.Peer-Reviewed Original ResearchConceptsOvarian cancer riskDepot medroxyprogesterone acetate useRisk of ovarian cancerDepot medroxyprogesterone acetateCancer riskOvarian cancerDecreased riskInverse associationRisk of invasive epithelial ovarian cancerRisk of ovarian cancer overallAssociated with decreased risk of ovarian cancerDecreased risk of ovarian cancerOvarian Cancer Association ConsortiumDecreased ovarian cancer riskSystematic reviewOvarian cancer overallInvasive epithelial ovarian cancerAssociated with decreased riskCombined oral contraceptive useInjectable progestin-only contraceptivesProgestin-only contraceptive useProgestin-releasing intrauterine deviceContraceptive useAssociated with ovarian cancerProgestin-only contraceptivesExposure and risk factors for COVID-19 and the impact of staying home on Michigan residents
Wu K, Hornsby W, Klunder B, Krause A, Driscoll A, Kulka J, Bickett-Hickok R, Fellows A, Graham S, Kaleba E, Hayek S, Shi X, Sutton N, Douville N, Mukherjee B, Jamerson K, Brummett C, Willer C. Exposure and risk factors for COVID-19 and the impact of staying home on Michigan residents. PLOS ONE 2021, 16: e0246447. PMID: 33556117, PMCID: PMC7870003, DOI: 10.1371/journal.pone.0246447.Peer-Reviewed Original ResearchConceptsAfrican AmericansAnnual household income <Worsening health behaviorsLong-term health outcomesHousehold income <Low socioeconomic statusExposure to family membersHigher overall concernHigh riskExposure to familyHigh risk of contracting COVID-19Positive COVID-19 testLow-income groupsHealth behaviorsHealth outcomesRates of COVID-19 casesRental housingSocioeconomic statusClinical careRisk of contracting COVID-19COVID-19 preventionChronic diseasesInequality gapState of MichiganCOVID-19 cases
2020
Patterns of repeated diagnostic testing for COVID‐19 in relation to patient characteristics and outcomes
Salerno S, Zhao Z, Sankar S, Salvatore M, Gu T, Fritsche L, Lee S, Lisabeth L, Valley T, Mukherjee B. Patterns of repeated diagnostic testing for COVID‐19 in relation to patient characteristics and outcomes. Journal Of Internal Medicine 2020, 289: 726-737. PMID: 33253457, PMCID: PMC7753604, DOI: 10.1111/joim.13213.Peer-Reviewed Original ResearchConceptsAssociated with repeat testingFalse-negative rateNeighborhood poverty levelPre-existing type 2 diabetesSevere COVID-19-related outcomesDiagnostic testsPatient characteristicsPre-existing kidney diseaseBody mass indexICU-level careHealth outcomesCOVID-19-related outcomesCharacteristics of patientsCOVID-19 diagnostic testsType 2 diabetesMichigan MedicineMass indexCOVID-19Pain symptomsPatient agePoverty levelDownstream outcomesKidney diseaseRepeated testingLiver diseaseDo black/white differences in telomere length depend on socioeconomic status?
Needham B, Salerno S, Roberts E, Boss J, Allgood K, Mukherjee B. Do black/white differences in telomere length depend on socioeconomic status? Biodemography And Social Biology 2020, 65: 287-312. PMID: 33243026, PMCID: PMC7703670, DOI: 10.1080/19485565.2020.1765734.Peer-Reviewed Original ResearchConceptsUS blacksNational Health and Nutrition Examination SurveyHealth and Nutrition Examination SurveyNutrition Examination SurveyAccelerated biological agingLeukocyte telomere lengthLonger telomere lengthExamination SurveyRisk of diseaseSocioeconomic statusHigher SESLow SESMiddle SESBlack/white differencesTelomere lengthRace differencesSESEconomic disadvantageBiological ageWhiteGenetic explanationBlackHealthDifferencesSurveyCancer PRSweb: An Online Repository with Polygenic Risk Scores for Major Cancer Traits and Their Evaluation in Two Independent Biobanks
Fritsche L, Patil S, Beesley L, VandeHaar P, Salvatore M, Ma Y, Peng R, Taliun D, Zhou X, Mukherjee B. Cancer PRSweb: An Online Repository with Polygenic Risk Scores for Major Cancer Traits and Their Evaluation in Two Independent Biobanks. American Journal Of Human Genetics 2020, 107: 815-836. PMID: 32991828, PMCID: PMC7675001, DOI: 10.1016/j.ajhg.2020.08.025.Peer-Reviewed Original ResearchConceptsPolygenic risk scoresGenome-wide association studiesMichigan Genomics InitiativeUK BiobankPopulation-based UK BiobankPolygenic risk score constructionPublished genome-wide association studiesLongitudinal biorepository effortAssociation studiesPredictive polygenic risk scoresRisk scoreNHGRI-EBI GWAS CatalogCancer traitsIndependent biobankMichigan MedicineGWAS CatalogGenome InitiativeBiobankScoresTraitsCancer researchOnline repositoryMichiganMedicineEvaluationUrinary metal mixtures and longitudinal changes in glucose homeostasis: The Study of Women’s Health Across the Nation (SWAN)
Wang X, Mukherjee B, Karvonen-Gutierrez C, Herman W, Batterman S, Harlow S, Park S. Urinary metal mixtures and longitudinal changes in glucose homeostasis: The Study of Women’s Health Across the Nation (SWAN). Environment International 2020, 145: 106109. PMID: 32927284, PMCID: PMC7577932, DOI: 10.1016/j.envint.2020.106109.Peer-Reviewed Original ResearchMeSH KeywordsCross-Sectional StudiesFemaleGlucoseHomeostasisHumansInsulin ResistanceMetalsMiddle AgedWomen's HealthConceptsEnvironmental risk scoreStudy of Women's HealthWomen's HealthExposure to metal mixturesElevated diabetes riskAssociated with lower HOMA-IRUrinary metal mixtureLongitudinal changesMetal mixturesHOMA-BYears of follow-upRate of changeHOMA-IRAdaptive elastic-netStandard deviation increaseDiabetes riskLinear mixed effects modelsLower HOMA-IRRandom interceptMixed effects modelsRisk scoreAssociated with higher HOMA-IRMetal mixture effectsEpidemiological studiesDeviation increase