Featured Publications
Exploring the Big Data Paradox for various estimands using vaccination data from the global COVID-19 Trends and Impact Survey (CTIS)
Yang Y, Dempsey W, Han P, Deshmukh Y, Richardson S, Tom B, Mukherjee B. Exploring the Big Data Paradox for various estimands using vaccination data from the global COVID-19 Trends and Impact Survey (CTIS). Science Advances 2024, 10: eadj0266. PMID: 38820165, PMCID: PMC11314312, DOI: 10.1126/sciadv.adj0266.Peer-Reviewed Original ResearchAssociation of Polygenic Risk Scores for Multiple Cancers in a Phenome-wide Study: Results from The Michigan Genomics Initiative
Fritsche L, Gruber S, Wu Z, Schmidt E, Zawistowski M, Moser S, Blanc V, Brummett C, Kheterpal S, Abecasis G, Mukherjee B. Association of Polygenic Risk Scores for Multiple Cancers in a Phenome-wide Study: Results from The Michigan Genomics Initiative. American Journal Of Human Genetics 2018, 102: 1048-1061. PMID: 29779563, PMCID: PMC5992124, DOI: 10.1016/j.ajhg.2018.04.001.Peer-Reviewed Original ResearchConceptsPolygenic risk scoresElectronic health recordsAssociations of polygenic risk scoresPhenome-wide significant associationsPolygenic risk score associationsLongitudinal biorepository effortNon-cancer diagnosesPatients' electronic health recordsPhenome-wide association studyAnalysis of temporal orderMichigan Genomics InitiativeRisk scoreAssociated with multiple phenotypesFemale breast cancerNHGRI-EBI CatalogRisk profileGenetic risk profilesMeasures of genomic variationCancer traitsCase-control studyPheWAS analysisHealth recordsHealth systemMichigan MedicineCancer diagnosisCharacteristics Associated With Racial/Ethnic Disparities in COVID-19 Outcomes in an Academic Health Care System
Gu T, Mack J, Salvatore M, Sankar S, Valley T, Singh K, Nallamothu B, Kheterpal S, Lisabeth L, Fritsche L, Mukherjee B. Characteristics Associated With Racial/Ethnic Disparities in COVID-19 Outcomes in an Academic Health Care System. JAMA Network Open 2020, 3: e2025197. PMID: 33084902, PMCID: PMC7578774, DOI: 10.1001/jamanetworkopen.2020.25197.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBetacoronavirusBlack or African AmericanComorbidityCoronavirus InfectionsCOVID-19Diabetes Mellitus, Type 2FemaleHealth Status DisparitiesHospitalizationHumansIntensive Care UnitsKidney DiseasesMaleMichiganMiddle AgedNeoplasmsObesityOdds RatioPandemicsPneumonia, ViralPopulation DensityRetrospective StudiesRisk FactorsSARS-CoV-2White PeopleConceptsAssociated with higher riskInternational Classification of DiseasesRisk of hospitalizationPreexisting type 2 diabetesHigher risk of hospitalizationClassification of DiseasesType 2 diabetesCOVID-19 outcomesRacial/ethnic disparitiesWhite patientsBlack patientsIntensive care unitInternational ClassificationResidential-level socioeconomic characteristicsOdds ratioStatistically significant racial differencesHigh riskAssociated with higher risk of hospitalizationNon-Hispanic blacksAssociation of risk factorsNon-Hispanic whitesMichigan Department of HealthAssociated with increased risk of hospitalizationComorbidity scoreDepartment of HealthRisk of Non-Melanoma Cancers in First-Degree Relatives of CDKN2A Mutation Carriers
Mukherjee B, DeLancey J, Raskin L, Everett J, Jeter J, Begg C, Orlow I, Berwick M, Armstrong B, Kricker A, Marrett L, Millikan R, Culver H, Rosso S, Zanetti R, Kanetsky P, From L, Gruber S, Investigators F. Risk of Non-Melanoma Cancers in First-Degree Relatives of CDKN2A Mutation Carriers. Journal Of The National Cancer Institute 2012, 104: 953-956. PMID: 22534780, PMCID: PMC3379723, DOI: 10.1093/jnci/djs221.Peer-Reviewed Original ResearchConceptsFirst-degree relatives of carriersCDKN2A mutation carriersFirst-degree relativesMutation carriersNon-melanoma cancersFirst-degree relatives of melanoma patientsFirst-degree relatives of mutation carriersKin-cohort methodConfidence intervalsRisk of cancerMelanoma patientsLifetime riskProband's genotypeNon-melanomaFamily membersIncreased riskGastrointestinal cancerCDKN2A mutationsWilms tumorRiskMelanoma StudyPancreatic cancerNoncarriersGenotype distributionMelanoma
2024
Cross-shift changes in pulmonary function and occupational exposure to particulate matter among e-waste workers in Ghana
Laskaris Z, O'Neill M, Batterman S, Mukherjee B, Fobil J, Robins T. Cross-shift changes in pulmonary function and occupational exposure to particulate matter among e-waste workers in Ghana. Frontiers In Public Health 2024, 12: 1368112. PMID: 38784567, PMCID: PMC11111984, DOI: 10.3389/fpubh.2024.1368112.Peer-Reviewed Original ResearchConceptsE-waste workersExposure to particulate matterE-wasteParticulate matterAgbogbloshie e-waste siteInhalation exposure to particulate matterE-waste sitesBurning e-wasteConcentrations of PMHealth-based guidelinesExposure to airborne pollutantsExposure to PMOccupational exposure to particulate matterCross-shift changesElectronic-wasteForced vital capacityPersonal PMPM exposureAirborne pollutantsLinear mixed modelsBreathing zone concentrationsPulmonary functionComparison populationRecovery workersMixed models
2023
Prenatal per- and polyfluoroalkyl substances (PFAS) exposure in relation to preterm birth subtypes and size-for-gestational age in the LIFECODES cohort 2006–2008
Siwakoti R, Cathey A, Ferguson K, Hao W, Cantonwine D, Mukherjee B, McElrath T, Meeker J. Prenatal per- and polyfluoroalkyl substances (PFAS) exposure in relation to preterm birth subtypes and size-for-gestational age in the LIFECODES cohort 2006–2008. Environmental Research 2023, 237: 116967. PMID: 37634691, PMCID: PMC10913455, DOI: 10.1016/j.envres.2023.116967.Peer-Reviewed Original ResearchConceptsLarge-for-gestational agePreterm birth subtypesBayesian kernel machine regressionSize-for-gestational ageSmall-for-gestational agePreterm birthFetal sexPregnancy outcomesSex-specific estimatesIncreased risk of adverse pregnancy outcomesInterquartile range increaseRisk of adverse pregnancy outcomesBayesian kernel machine regression analysisEarly pregnancy samplesAdverse pregnancy outcomesCase-control studyPrenatal PFAS exposureAssociations of polyfluoroalkyl substancesBW z-scoreEffects of polyfluoroalkyl substancesKernel machine regressionEffect modificationEffects of prenatal exposureRange increaseStratified analysisFactor in gender to beat the heat in impoverished settlements
Bardhan R, Debnath R, Mukherjee B. Factor in gender to beat the heat in impoverished settlements. Nature 2023, 620: 727-727. PMID: 37608008, DOI: 10.1038/d41586-023-02632-3.Peer-Reviewed Original ResearchCohort profile: Epidemiologic Questionnaire (EPI-Q) – a scalable, app-based health survey linked to electronic health record and genotype data
Salvatore M, Clark-Boucher D, Fritsche L, Ortlieb J, Houghtby J, Driscoll A, Caldwell-Larkins B, Smith J, Brummett C, Kheterpal S, Lisabeth L, Mukherjee B. Cohort profile: Epidemiologic Questionnaire (EPI-Q) – a scalable, app-based health survey linked to electronic health record and genotype data. Epidemiology And Health 2023, 45: e2023074. PMID: 37591787, PMCID: PMC10867525, DOI: 10.4178/epih.e2023074.Peer-Reviewed Original ResearchConceptsElectronic health recordsHealth recordsSelf-reported health dataFamily health historyEpidemiological questionnaireCancer screeningHealth cohortHealth SurveyHealth historyFinancial toxicityBaseline surveyEHR dataHealth dataCohort dataEPI-QAverage ageOccupational exposureGenotype dataParticipantsGenotype informationInstitutional review board approvalResponse rateCohortLife meaningQuestionnaireAdverse birth outcomes are associated with circulating matrix metalloproteinases among pregnant women in Puerto Rico
Kim C, Cathey A, Watkins D, Mukherjee B, Rosario-Pabón Z, Vélez-Vega C, Alshawabkeh A, Cordero J, Meeker J. Adverse birth outcomes are associated with circulating matrix metalloproteinases among pregnant women in Puerto Rico. Journal Of Reproductive Immunology 2023, 159: 103991. PMID: 37454540, PMCID: PMC10726844, DOI: 10.1016/j.jri.2023.103991.Peer-Reviewed Original ResearchConceptsBirth outcomesMatrix metalloproteinasesFetal sexPregnant womenFemale fetusesNewborn lengthVisit 3Associated with increased odds of preeclampsiaVisit 1Impact of matrix metalloproteinasesCustomized Luminex assayGestational diabetes mellitusOdds of preeclampsiaAdverse birth outcomesAssociated with increased oddsGestational ageHealthy pregnancyMale fetusesUterine remodelingLuminex assayLogistic regression modelsDiabetes mellitusStudy visitsInverse associationExtracellular matrixAn inverse probability weighted regression method that accounts for right‐censoring for causal inference with multiple treatments and a binary outcome
Yu Y, Zhang M, Mukherjee B. An inverse probability weighted regression method that accounts for right‐censoring for causal inference with multiple treatments and a binary outcome. Statistics In Medicine 2023, 42: 3699-3715. PMID: 37392070, DOI: 10.1002/sim.9826.Peer-Reviewed Original ResearchConceptsRight censoringWeighted score functionCausal treatment effectsAverage treatment effectAsymptotic propertiesCensored componentPre-specified time windowEstimation consistencyRobustness propertiesSimulation studyBinary outcomesPresence of confoundersCensoringScoring functionInverse probabilityTreatment effectsEstimationSources of biasInferenceLetter CComparative effectiveness researchTreatment switchRegression methodLogistic regression modelsInsurance claims databaseA Synthetic Data Integration Framework to Leverage External Summary-Level Information from Heterogeneous Populations
Gu T, Taylor J, Mukherjee B. A Synthetic Data Integration Framework to Leverage External Summary-Level Information from Heterogeneous Populations. Biometrics 2023, 79: 3831-3845. PMID: 36876883, PMCID: PMC10480346, DOI: 10.1111/biom.13852.Peer-Reviewed Original ResearchConceptsCovariate effectsStatistical inferenceHeterogeneity of covariate effectsRegression coefficient estimatesSummary-level informationImprove statistical inferenceInternational studiesOutcome YCovariate informationData integration frameworkStatistical efficiencyCoefficient estimatesPartial informationExternal populationGeneral frameworkIndividual-level dataRisk prediction modelExternal modelPrediction problemInternational study populationMultiple imputation
2022
Predicting cumulative lead (Pb) exposure using the Super Learner algorithm
Wang X, Bakulski K, Mukherjee B, Hu H, Park S. Predicting cumulative lead (Pb) exposure using the Super Learner algorithm. Chemosphere 2022, 311: 137125. PMID: 36347347, PMCID: PMC10160242, DOI: 10.1016/j.chemosphere.2022.137125.Peer-Reviewed Original ResearchConceptsPatella leadNational Health and Nutrition Examination SurveyHealth and Nutrition Examination SurveyNutrition Examination SurveyLong-term health effectsPopulation-based studyK-shell X-ray fluorescenceNormative Aging StudyCumulative lead exposureEvaluate health effectsExamination SurveyLead concentrationsBone lead measurementsAging StudyTibia leadPositive associationStudy populationHealth effectsRegression-based predictive modelBone lead concentrationsBlood pressureFlexible machine learning approachCorrelation coefficientX-ray fluorescence techniqueLead measurementsOccupational history associates with ALS survival and onset segment
Goutman S, Boss J, Godwin C, Mukherjee B, Feldman E, Batterman S. Occupational history associates with ALS survival and onset segment. Amyotrophic Lateral Sclerosis And Frontotemporal Degeneration 2022, 24: 219-229. PMID: 36193557, PMCID: PMC10067530, DOI: 10.1080/21678421.2022.2127324.Peer-Reviewed Original ResearchConceptsStandard Occupational ClassificationOccupational settingsOnset segmentSelf-reported occupational exposureAmyotrophic Lateral Sclerosis RegistrySelf-reported exposureExposure to particulate matterCervical onsetStandard Occupational Classification codesMultinomial logistic regression modelCox proportional hazards modelsLogistic regression modelsSymptom onset to diagnosisOccupational pesticide exposureProportional hazards modelAssociated with workMaintenance occupationsGrounds cleaningALS clinicALS participantsProspective cohortAdjusted modelsDiagnosis ageAmyotrophic lateral sclerosis participantsOccupational historyUnderstanding Baseline Physical Activity in Cardiac Rehabilitation Enrollees Using Mobile Health Technologies
Golbus J, Gupta K, Stevens R, Jeganathan V, Luff E, Boyden T, Mukherjee B, Klasnja P, Kheterpal S, Kohnstamm S, Nallamothu B. Understanding Baseline Physical Activity in Cardiac Rehabilitation Enrollees Using Mobile Health Technologies. Circulation Cardiovascular Quality And Outcomes 2022, 15: e009182. PMID: 35559648, PMCID: PMC9308648, DOI: 10.1161/circoutcomes.122.009182.Peer-Reviewed Original ResearchConceptsBaseline physical activityMobile health technologyCardiac rehabilitationPhysical activityExercise minutesHealth technologiesWalking distanceRehabilitation indicatorsModerate-risk patientsAssociated with daily step countsPhysical activity of patientsDaily step countCardiac rehabilitation programMobile health interventionsInitiate cardiac rehabilitationPatient-level featuresActivity of patientsMultivariate linear regressionStep countsUsual careRehabilitation programHealth interventionsAssociated with ageWear timePersonal careBiomarkers of Exposure to Phthalate Mixtures and Adverse Birth Outcomes in a Puerto Rico Birth Cohort
Cathey A, Watkins D, Rosario Z, Vélez C, Mukherjee B, Alshawabkeh A, Cordero J, Meeker J. Biomarkers of Exposure to Phthalate Mixtures and Adverse Birth Outcomes in a Puerto Rico Birth Cohort. Environmental Health Perspectives 2022, 130: 037009. PMID: 35333099, PMCID: PMC8953418, DOI: 10.1289/ehp8990.Peer-Reviewed Original ResearchConceptsSpontaneous preterm birthPreterm birthFetal sexGestational agePregnancy outcomesBirth outcomesBayesian kernel machine regressionPhthalate metabolitesRisk of early deliveryAssociated with increased odds of PTBOdds of preterm birthPhthalate mixtureReduced gestational ageIndividual phthalate metabolitesMeasures of birth weightAssociated with increased riskPhthalate metabolite mixturesAdverse birth outcomesAssociated with increased oddsPuerto Rico TestsiteEnvironmental risk scoreEarly deliveryBirth weightPregnancy cohortLongitudinal pregnancy cohortDepression, Anxiety, and Patterns of Mental Health Care Among Men With Prostate Cancer Receiving Androgen Deprivation Therapy
Tsao P, Ross R, Bohnert A, Mukherjee B, Caram M. Depression, Anxiety, and Patterns of Mental Health Care Among Men With Prostate Cancer Receiving Androgen Deprivation Therapy. The Oncologist 2022, 27: 314-322. PMID: 35298660, PMCID: PMC8982372, DOI: 10.1093/oncolo/oyab033.Peer-Reviewed Original ResearchConceptsAndrogen deprivation therapyMental health careProstate cancerMental health treatmentDiagnosis of depressionHealth careOptum's de-identified Clinformatics Data Mart DatabaseProstate cancer treated with androgen deprivation therapyInitiation of androgen deprivation therapyHealth treatmentPatterns of mental health careClinformatics Data Mart DatabaseSerotonin reuptake inhibitorsAnxiety diagnosesPsychotropic medicationsSpecialty of providersData Mart DatabasePrimary care physiciansPrescribing of psychotropic medicationsIncidence of depressionProportion of menDeprivation therapyReuptake inhibitorsMedian timeProstateMaternal blood metal concentrations are associated with matrix metalloproteinases (MMPs) among pregnant women in Puerto Rico
Kim C, Cathey A, Watkins D, Mukherjee B, Rosario-Pabón Z, Vélez-Vega C, Alshawabkeh A, Cordero J, Meeker J. Maternal blood metal concentrations are associated with matrix metalloproteinases (MMPs) among pregnant women in Puerto Rico. Environmental Research 2022, 209: 112874. PMID: 35123972, PMCID: PMC10443181, DOI: 10.1016/j.envres.2022.112874.Peer-Reviewed Original ResearchConceptsBlood metal concentrationsAdverse birth outcomesMetal concentrationsAssociated with matrix metalloproteinasesMatrix metalloproteinasesBirth outcomesFetal sexHealthy pregnancyLinear mixed effects modelsUterine remodelingPregnant womenFemale fetusesExposure to heavy metalsHeavy metal exposureCustomized Luminex assayFetal sex effectLevels of inflammatory cytokinesTrimester of pregnancyBlood metal levelsMetal levelsHeavy metalsMetal exposureMeasured blood concentrationsLuminex assayMale fetusesMediation by hormone concentrations on the associations between repeated measures of phthalate mixture exposure and timing of delivery
Cathey A, Aung M, Watkins D, Rosario Z, Vélez Vega C, Alshawabkeh A, Cordero J, Mukherjee B, Meeker J. Mediation by hormone concentrations on the associations between repeated measures of phthalate mixture exposure and timing of delivery. Journal Of Exposure Science & Environmental Epidemiology 2022, 32: 374-383. PMID: 34987188, PMCID: PMC9124667, DOI: 10.1038/s41370-021-00408-3.Peer-Reviewed Original ResearchConceptsSpontaneous preterm birthPreterm birthCorticotropin-releasing hormoneFetal sexMale fetusesEarly deliveryHormone concentrationsAssociated with earlier deliveryPhthalate exposurePhthalate mixtureReduced gestational ageTime of deliveryEnvironmental risk scoreGestational ageFemale fetusesUrinary phthalatesSex-specific analysesEndocrine-disrupting capabilitiesReleasing hormoneSerum hormonesFetusesRisk scoreSusceptible to endocrine disruptionBirth cohortHormone
2021
Gestational Hormone Concentrations Are Associated With Timing of Delivery in a Fetal Sex-Dependent Manner
Cathey A, Watkins D, Rosario Z, Vega C, Mukherjee B, O’Neill M, Loch-Caruso R, Alshawabkeh A, Cordero J, Meeker J. Gestational Hormone Concentrations Are Associated With Timing of Delivery in a Fetal Sex-Dependent Manner. Frontiers In Endocrinology 2021, 12: 742145. PMID: 34603214, PMCID: PMC8479114, DOI: 10.3389/fendo.2021.742145.Peer-Reviewed Original ResearchConceptsTime of deliveryFetal sexBody mass indexGestational ageMaternal agePreterm premature rupture of membranesPre-pregnancy body mass indexHormone concentrationsFetal sex-specific effectsPremature rupture of membranesOverall preterm birthPreterm premature ruptureSpontaneous preterm laborRupture of membranesReduced gestational ageOdds of PTBTime of laborSignificant public health problemTobacco smoke exposureGestational hormonesSpontaneous PTBPreterm laborWeeks gestationPreterm birthLongitudinal birth cohortIncorporating false negative tests in epidemiological models for SARS-CoV-2 transmission and reconciling with seroprevalence estimates
Bhattacharyya R, Kundu R, Bhaduri R, Ray D, Beesley L, Salvatore M, Mukherjee B. Incorporating false negative tests in epidemiological models for SARS-CoV-2 transmission and reconciling with seroprevalence estimates. Scientific Reports 2021, 11: 9748. PMID: 33963259, PMCID: PMC8105357, DOI: 10.1038/s41598-021-89127-1.Peer-Reviewed Original Research