2020
Urinary metal mixtures and longitudinal changes in glucose homeostasis: The Study of Women’s Health Across the Nation (SWAN)
Wang X, Mukherjee B, Karvonen-Gutierrez C, Herman W, Batterman S, Harlow S, Park S. Urinary metal mixtures and longitudinal changes in glucose homeostasis: The Study of Women’s Health Across the Nation (SWAN). Environment International 2020, 145: 106109. PMID: 32927284, PMCID: PMC7577932, DOI: 10.1016/j.envint.2020.106109.Peer-Reviewed Original ResearchMeSH KeywordsCross-Sectional StudiesFemaleGlucoseHomeostasisHumansInsulin ResistanceMetalsMiddle AgedWomen's HealthConceptsEnvironmental risk scoreStudy of Women's HealthWomen's HealthExposure to metal mixturesElevated diabetes riskAssociated with lower HOMA-IRUrinary metal mixtureLongitudinal changesMetal mixturesHOMA-BYears of follow-upRate of changeHOMA-IRAdaptive elastic-netStandard deviation increaseDiabetes riskLinear mixed effects modelsLower HOMA-IRRandom interceptMixed effects modelsRisk scoreAssociated with higher HOMA-IRMetal mixture effectsEpidemiological studiesDeviation increase
2015
Extreme Air Pollution Conditions Adversely Affect Blood Pressure and Insulin Resistance
Brook R, Sun Z, Brook J, Zhao X, Ruan Y, Yan J, Mukherjee B, Rao X, Duan F, Sun L, Liang R, Lian H, Zhang S, Fang Q, Gu D, Sun Q, Fan Z, Rajagopalan S. Extreme Air Pollution Conditions Adversely Affect Blood Pressure and Insulin Resistance. Hypertension 2015, 67: 77-85. PMID: 26573709, PMCID: PMC4830086, DOI: 10.1161/hypertensionaha.115.06237.Peer-Reviewed Original ResearchConceptsFine particulate matterParticulate matterAmbient fine particulate matterSD increaseAssociated with worsening insulin resistanceBlack carbon levelsBlack carbon exposurePublic health warningsAir pollutionBeijing metropolitan areaBlack carbonHealth warningsAssociated with rangeCardiometabolic healthCarbon levelsDiastolic blood pressureExposure windowsCardiometabolic diseasesHealth effectsNonsmoking adultsMetabolic syndromeDeveloping world todayCarbon exposureSystolic blood pressure elevationHealth
2014
Central IKKβ inhibition prevents air pollution mediated peripheral inflammation and exaggeration of type II diabetes
Liu C, Fonken L, Wang A, Maiseyeu A, Bai Y, Wang T, Maurya S, Ko Y, Periasamy M, Dvonch T, Morishita M, Brook R, Harkema J, Ying Z, Mukherjee B, Sun Q, Nelson R, Rajagopalan S. Central IKKβ inhibition prevents air pollution mediated peripheral inflammation and exaggeration of type II diabetes. Particle And Fibre Toxicology 2014, 11: 53. PMID: 25358444, PMCID: PMC4226918, DOI: 10.1186/s12989-014-0053-5.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, MonoclonalAnti-Inflammatory AgentsBenzamidesBlood GlucoseDiabetes Mellitus, Type 2Disease Models, AnimalEnergy MetabolismHypothalamusI-kappa B KinaseInflammationInfliximabInhalation ExposureInjections, IntraventricularInsulinInsulin ResistanceInterleukin-6MiceOxygen ConsumptionParticulate MatterProtein Kinase InhibitorsRisk AssessmentRNA, MessengerThermogenesisTime FactorsTumor Necrosis Factor-alpha
2012
Air-Pollution and Cardiometabolic Diseases (AIRCMD): A prospective study investigating the impact of air pollution exposure and propensity for type II diabetes
Sun Z, Mukherjee B, Brook R, Gatts G, Yang F, Sun Q, Brook J, Fan Z, Rajagopalan S. Air-Pollution and Cardiometabolic Diseases (AIRCMD): A prospective study investigating the impact of air pollution exposure and propensity for type II diabetes. The Science Of The Total Environment 2012, 448: 72-78. PMID: 23182147, PMCID: PMC4548977, DOI: 10.1016/j.scitotenv.2012.10.087.Peer-Reviewed Original ResearchConceptsAir pollution exposureAir pollutionAmbient fine particulate matterMeasures of air pollution exposureImpact of air pollution exposureFine particulate matterExposure to PM2.5Air pollution measurementsPersonal exposure measurementsCreation of novel methodologiesSub-acute exposurePolluted urban environmentsImpact of environmental factorsParticulate matterPollution exposureStudy visitsPollution measurementsType II diabetesProspective cohort studyEnvironmental risk factorsAmbient measurementsII diabetesCohort studyUrban environmentScreening visit