Featured Publications
Characteristics Associated With Racial/Ethnic Disparities in COVID-19 Outcomes in an Academic Health Care System
Gu T, Mack J, Salvatore M, Sankar S, Valley T, Singh K, Nallamothu B, Kheterpal S, Lisabeth L, Fritsche L, Mukherjee B. Characteristics Associated With Racial/Ethnic Disparities in COVID-19 Outcomes in an Academic Health Care System. JAMA Network Open 2020, 3: e2025197. PMID: 33084902, PMCID: PMC7578774, DOI: 10.1001/jamanetworkopen.2020.25197.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBetacoronavirusBlack or African AmericanComorbidityCoronavirus InfectionsCOVID-19Diabetes Mellitus, Type 2FemaleHealth Status DisparitiesHospitalizationHumansIntensive Care UnitsKidney DiseasesMaleMichiganMiddle AgedNeoplasmsObesityOdds RatioPandemicsPneumonia, ViralPopulation DensityRetrospective StudiesRisk FactorsSARS-CoV-2White PeopleConceptsAssociated with higher riskInternational Classification of DiseasesRisk of hospitalizationPreexisting type 2 diabetesHigher risk of hospitalizationClassification of DiseasesType 2 diabetesCOVID-19 outcomesRacial/ethnic disparitiesWhite patientsBlack patientsIntensive care unitInternational ClassificationResidential-level socioeconomic characteristicsOdds ratioStatistically significant racial differencesHigh riskAssociated with higher risk of hospitalizationNon-Hispanic blacksAssociation of risk factorsNon-Hispanic whitesMichigan Department of HealthAssociated with increased risk of hospitalizationComorbidity scoreDepartment of HealthRisk of Non-Melanoma Cancers in First-Degree Relatives of CDKN2A Mutation Carriers
Mukherjee B, DeLancey J, Raskin L, Everett J, Jeter J, Begg C, Orlow I, Berwick M, Armstrong B, Kricker A, Marrett L, Millikan R, Culver H, Rosso S, Zanetti R, Kanetsky P, From L, Gruber S, Investigators F. Risk of Non-Melanoma Cancers in First-Degree Relatives of CDKN2A Mutation Carriers. Journal Of The National Cancer Institute 2012, 104: 953-956. PMID: 22534780, PMCID: PMC3379723, DOI: 10.1093/jnci/djs221.Peer-Reviewed Original ResearchConceptsFirst-degree relatives of carriersCDKN2A mutation carriersFirst-degree relativesMutation carriersNon-melanoma cancersFirst-degree relatives of melanoma patientsFirst-degree relatives of mutation carriersKin-cohort methodConfidence intervalsRisk of cancerMelanoma patientsLifetime riskProband's genotypeNon-melanomaFamily membersIncreased riskGastrointestinal cancerCDKN2A mutationsWilms tumorRiskMelanoma StudyPancreatic cancerNoncarriersGenotype distributionMelanoma
2023
Mortality and Severe Complications Among Newly Graduated Surgeons in the United States
Howard R, Thelen A, Chen X, Gates R, Krumm A, Millis M, Gupta T, Brown C, Bandeh-Ahmadi H, Wnuk G, Yee C, Ryan A, Mukherjee B, Dimick J, George B. Mortality and Severe Complications Among Newly Graduated Surgeons in the United States. Annals Of Surgery 2023, 279: 555-560. PMID: 37830271, PMCID: PMC10939969, DOI: 10.1097/sla.0000000000006128.Peer-Reviewed Original ResearchConceptsYears of practiceSevere complicationsRelative riskGeneral surgeonsIndependent practiceYears of independent practiceCareer surgeonsRelative risk of mortalityAmerican Board of SurgerySurgeon yearsMixed modelsSurgeon characteristicsRate of mortalityMedicare claimsComplicationsSurgeonsPatient outcomesPatientsMortalityAmerican BoardOutcomesEvaluating Educational Outcomes Using Patient Outcomes of New Surgeons Performing Partial Colectomy Compared to Cholecystectomy
George B, Thelen A, Howard R, Kendrick D, Chen X, Clark M, Gupta T, Brown C, Bandeh-Ahmadi H, Luckoski J, Wnuk G, Fan Z, Krumm A, Ryan A, Buyske J, Mukherjee B, Dimick J. Evaluating Educational Outcomes Using Patient Outcomes of New Surgeons Performing Partial Colectomy Compared to Cholecystectomy. Academic Medicine 2023, 98: s143-s148. PMID: 37983406, DOI: 10.1097/acm.0000000000005368.Peer-Reviewed Original ResearchConceptsPartial colectomyPatient outcomesYears of practiceExperienced surgeonSurgeon yearsRisk-adjusted ratesCholecystectomyColectomyTraining of surgeonsInpatient cholecystectomyComplicationsImprove surgical educationPatientsEvaluate educational outcomesSurgeonsSurgical residentsBenefit patientsInpatient operationsResidency trainingStudy periodDeathOutcomesSurgical educationMixed modelsTrainingAssociation of Surgical Resident Competency Ratings With Patient Outcomes
Kendrick D, Thelen A, Chen X, Gupta T, Yamazaki K, Krumm A, Bandeh-Ahmadi H, Clark M, Luckoscki J, Fan Z, Wnuk G, Ryan A, Mukherjee B, Hamstra S, Dimick J, Holmboe E, George B. Association of Surgical Resident Competency Ratings With Patient Outcomes. Academic Medicine 2023, 98: 813-820. PMID: 36724304, DOI: 10.1097/acm.0000000000005157.Peer-Reviewed Original ResearchConceptsPatient outcomesGeneral surgery residentsMilestone ratingsSevere complicationsInpatient general surgical proceduresSurgery residentsGeneral surgical proceduresHigh-risk procedureCross-sectional studyCompetency ratingsGeneral surgical residentsRisk-adjusted ratesClinical outcomesIndex operationSurgical proceduresGeneral surgeonsMedicare populationComplicationsNational MedicareYears of practiceSecondary analysisClinical performanceSurgical residentsOutcomesMortality
2022
Understanding Baseline Physical Activity in Cardiac Rehabilitation Enrollees Using Mobile Health Technologies
Golbus J, Gupta K, Stevens R, Jeganathan V, Luff E, Boyden T, Mukherjee B, Klasnja P, Kheterpal S, Kohnstamm S, Nallamothu B. Understanding Baseline Physical Activity in Cardiac Rehabilitation Enrollees Using Mobile Health Technologies. Circulation Cardiovascular Quality And Outcomes 2022, 15: e009182. PMID: 35559648, PMCID: PMC9308648, DOI: 10.1161/circoutcomes.122.009182.Peer-Reviewed Original ResearchConceptsBaseline physical activityMobile health technologyCardiac rehabilitationPhysical activityExercise minutesHealth technologiesWalking distanceRehabilitation indicatorsModerate-risk patientsAssociated with daily step countsPhysical activity of patientsDaily step countCardiac rehabilitation programMobile health interventionsInitiate cardiac rehabilitationPatient-level featuresActivity of patientsMultivariate linear regressionStep countsUsual careRehabilitation programHealth interventionsAssociated with ageWear timePersonal careHigh pre-diagnosis inflammation-related risk score associated with decreased ovarian cancer survival
Brieger KK, Phung MT, Mukherjee B, Bakulski KM, Anton-Culver H, Bandera EV, Bowtell DDL, Cramer DW, DeFazio A, Doherty JA, Fereday S, Fortner RT, Gentry-Maharaj A, Goode EL, Goodman MT, Harris HR, Matsuo K, Menon U, Modugno F, Moysich KB, Qin B, Ramus SJ, Risch HA, Rossing MA, Schildkraut JM, Trabert B, Vierkant RA, Winham SJ, Wentzensen N, Wu AH, Ziogas A, Khoja L, Cho KR, McLean K, Richardson J, Grout B, Chase A, Deurloo CM, Odunsi K, Nelson BH, Brenton JD, Terry KL, Pharaoh P, Berchuck A, Hanley GE, Webb PM, Pike MC, Pearce CL. High pre-diagnosis inflammation-related risk score associated with decreased ovarian cancer survival. Cancer Epidemiology Biomarkers & Prevention 2022, 31: cebp.epi-21-0977-a.2021. PMID: 34789471, PMCID: PMC9281656, DOI: 10.1158/1055-9965.epi-21-0977.Peer-Reviewed Original ResearchConceptsOvarian cancer survivalCox proportional hazards modelProportional hazards modelCancer survivalOvarian cancerRisk scoreHazards modelNonsteroidal anti-inflammatory drug useAnti-inflammatory drug useMenopausal hormone therapy useEnvironmental tobacco smoke exposureInvasive epithelial ovarian cancerHormone therapy usePelvic inflammatory diseaseInflammation-related factorsPolycystic ovarian syndromeTobacco smoke exposureBody mass indexRisk of deathEpithelial ovarian cancerOvarian Cancer Association ConsortiumOvarian cancer diagnosisHigh death rateAspirin useOvarian syndrome
2021
Exposure to Primary Air Pollutants Generated by Highway Traffic and Daily Mortality Risk in Near-Road Communities: A Case-Crossover Study
Filigrana P, Milando C, Batterman S, Levy J, Mukherjee B, Pedde M, Szpiro A, Adar S. Exposure to Primary Air Pollutants Generated by Highway Traffic and Daily Mortality Risk in Near-Road Communities: A Case-Crossover Study. American Journal Of Epidemiology 2021, 191: 63-74. PMID: 34347034, DOI: 10.1093/aje/kwab215.Peer-Reviewed Original ResearchConceptsNear-road populationsAir pollutionMortality riskExposure to traffic-related air pollutionAverage PM2.5 exposureTraffic-generated air pollutionNear-road communitiesResearch LINE sourceConcentrations of PM2.5Traffic-related air pollutionCase-crossover designPrimary air pollutantsConditional logistic regressionPuget Sound area of Washington StateDaily mortality riskCase-crossoverTime-varying covariatesCerebrovascular mortalityPM2.5 exposurePrimary pollutantsQuantify associationsAerodynamic diameterShorter averaging periodsPM2.5PollutionExposure and risk factors for COVID-19 and the impact of staying home on Michigan residents
Wu K, Hornsby W, Klunder B, Krause A, Driscoll A, Kulka J, Bickett-Hickok R, Fellows A, Graham S, Kaleba E, Hayek S, Shi X, Sutton N, Douville N, Mukherjee B, Jamerson K, Brummett C, Willer C. Exposure and risk factors for COVID-19 and the impact of staying home on Michigan residents. PLOS ONE 2021, 16: e0246447. PMID: 33556117, PMCID: PMC7870003, DOI: 10.1371/journal.pone.0246447.Peer-Reviewed Original ResearchConceptsAfrican AmericansAnnual household income <Worsening health behaviorsLong-term health outcomesHousehold income <Low socioeconomic statusExposure to family membersHigher overall concernHigh riskExposure to familyHigh risk of contracting COVID-19Positive COVID-19 testLow-income groupsHealth behaviorsHealth outcomesRates of COVID-19 casesRental housingSocioeconomic statusClinical careRisk of contracting COVID-19COVID-19 preventionChronic diseasesInequality gapState of MichiganCOVID-19 cases
2020
Cancer PRSweb: An Online Repository with Polygenic Risk Scores for Major Cancer Traits and Their Evaluation in Two Independent Biobanks
Fritsche L, Patil S, Beesley L, VandeHaar P, Salvatore M, Ma Y, Peng R, Taliun D, Zhou X, Mukherjee B. Cancer PRSweb: An Online Repository with Polygenic Risk Scores for Major Cancer Traits and Their Evaluation in Two Independent Biobanks. American Journal Of Human Genetics 2020, 107: 815-836. PMID: 32991828, PMCID: PMC7675001, DOI: 10.1016/j.ajhg.2020.08.025.Peer-Reviewed Original ResearchConceptsPolygenic risk scoresGenome-wide association studiesMichigan Genomics InitiativeUK BiobankPopulation-based UK BiobankPolygenic risk score constructionPublished genome-wide association studiesLongitudinal biorepository effortAssociation studiesPredictive polygenic risk scoresRisk scoreNHGRI-EBI GWAS CatalogCancer traitsIndependent biobankMichigan MedicineGWAS CatalogGenome InitiativeBiobankScoresTraitsCancer researchOnline repositoryMichiganMedicineEvaluationMenopausal hormone therapy prior to the diagnosis of ovarian cancer is associated with improved survival
Brieger KK, Peterson S, Lee AW, Mukherjee B, Bakulski KM, Alimujiang A, Anton-Culver H, Anglesio MS, Bandera EV, Berchuck A, Bowtell DDL, Chenevix-Trench G, Cho KR, Cramer DW, DeFazio A, Doherty JA, Fortner RT, Garsed DW, Gayther SA, Gentry-Maharaj A, Goode EL, Goodman MT, Harris HR, Høgdall E, Huntsman DG, Shen H, Jensen A, Johnatty SE, Jordan SJ, Kjaer SK, Kupryjanczyk J, Lambrechts D, McLean K, Menon U, Modugno F, Moysich K, Ness R, Ramus SJ, Richardson J, Risch H, Rossing MA, Trabert B, Wentzensen N, Ziogas A, Terry KL, Wu AH, Hanley GE, Pharoah P, Webb PM, Pike MC, Pearce CL, Consortium F. Menopausal hormone therapy prior to the diagnosis of ovarian cancer is associated with improved survival. Gynecologic Oncology 2020, 158: 702-709. PMID: 32641237, PMCID: PMC7487048, DOI: 10.1016/j.ygyno.2020.06.481.Peer-Reviewed Original ResearchConceptsMenopausal hormone therapyOvarian cancer survivalMHT useResidual diseaseHormone therapyCancer survivalOvarian cancerHigh-grade serous carcinomaMacroscopic residual diseaseHormone therapy useFavorable prognostic factorPost-menopausal womenOvarian Cancer Association ConsortiumProportional hazards modelRecency of useImproved survivalPrognostic factorsTherapy useSerous carcinomaOvarian carcinomaHazards modelSmall studyAdvanced stageLarger studyLogistic regressionSocial regulation of inflammation related gene expression in the multi-ethnic study of atherosclerosis
Brown K, Diez-Roux A, Smith J, Needham B, Mukherjee B, Ware E, Liu Y, Cole S, Seeman T, Kardia S. Social regulation of inflammation related gene expression in the multi-ethnic study of atherosclerosis. Psychoneuroendocrinology 2020, 117: 104654. PMID: 32387875, PMCID: PMC7685527, DOI: 10.1016/j.psyneuen.2020.104654.Peer-Reviewed Original ResearchConceptsGene expressionMulti-Ethnic Study of AtherosclerosisGene set enrichment testGene Ontology databaseGene expression dataMulti-Ethnic StudyLifetime discriminationStudy of AtherosclerosisDifferential gene expressionInflammation-related genesExpression dataGene setsChronic burdenSocial factorsGene transcriptionRelated gene expressionOntology databaseGenesInflammatory responseTranscriptionGlobal analysisElastic net penalized regressionAdverse social factorsGlobal expressionExpression of inflammation-related genes
2019
Does Information on Blood Heavy Metals Improve Cardiovascular Mortality Prediction?
Wang X, Mukherjee B, Park S. Does Information on Blood Heavy Metals Improve Cardiovascular Mortality Prediction? Journal Of The American Heart Association 2019, 8: e013571. PMID: 31631727, PMCID: PMC6898859, DOI: 10.1161/jaha.119.013571.Peer-Reviewed Original ResearchConceptsCardiovascular diseaseNational Health and Nutrition Examination SurveyHealth and Nutrition Examination SurveyRisk factorsStudy sampleCardiovascular disease risk factorsCardiovascular disease mortalityCardiovascular disease risk assessmentImprove CVD risk predictionC-statisticNutrition Examination SurveyCardiovascular mortality predictionCVD risk predictionCox modelBlood markersExamination SurveyPrecision healthRisk scorePairwise interaction termsBlood metalsIntegrated discrimination improvementRisk predictionReclassification improvementMortality predictionInteraction termsExpression of socially sensitive genes: The multi-ethnic study of atherosclerosis
Brown K, Diez-Roux A, Smith J, Needham B, Mukherjee B, Ware E, Liu Y, Cole S, Seeman T, Kardia S. Expression of socially sensitive genes: The multi-ethnic study of atherosclerosis. PLOS ONE 2019, 14: e0214061. PMID: 30973896, PMCID: PMC6459532, DOI: 10.1371/journal.pone.0214061.Peer-Reviewed Original ResearchConceptsGene expressionSocial factorsAdult socioeconomic statusPopulation-based cohortMulti-Ethnic StudyMarginal significant associationPercentage of genesInfluence gene expressionLinear regressionExpression of genesLifetime discriminationSocioeconomic statusChronic burdenOverall healthInvestigate associationsGene approachGene setsLinear regression analysisSignificant associationGenesExpression patternsMultiple testingSensitive to social factorsCell typesRegression analysisFactors Associated With Use of Sipuleucel-T to Treat Patients With Advanced Prostate Cancer
Caram M, Ross R, Lin P, Mukherjee B. Factors Associated With Use of Sipuleucel-T to Treat Patients With Advanced Prostate Cancer. JAMA Network Open 2019, 2: e192589. PMID: 31002323, PMCID: PMC6481456, DOI: 10.1001/jamanetworkopen.2019.2589.Peer-Reviewed Original ResearchConceptsMinimally symptomatic metastatic castration-resistant prostate cancerSipuleucel-TProstate cancerSymptomatic metastatic castration-resistant prostate cancerDatabase of commercially insured patientsMetastatic castration-resistant prostate cancerCastration-resistant prostate cancerAge of patientsRetrospective cohort studyFactors associated with useAssociated with patientsCommercially insured patientsPatterns of treatmentConcurrent therapyTreated patientsCohort studyMultivariate analysisCancer therapyTherapyPatientsPhysician factorsCancerBarriers to treatmentBinomial logistic regressionLogistic regression
2018
Associations of cumulative exposure to heavy metal mixtures with obesity and its comorbidities among U.S. adults in NHANES 2003–2014
Wang X, Mukherjee B, Park S. Associations of cumulative exposure to heavy metal mixtures with obesity and its comorbidities among U.S. adults in NHANES 2003–2014. Environment International 2018, 121: 683-694. PMID: 30316184, PMCID: PMC6268112, DOI: 10.1016/j.envint.2018.09.035.Peer-Reviewed Original ResearchConceptsEnvironmental risk scoreAssociated with obesityHeavy metal mixturesHeavy metalsMetal mixturesAssociation of cumulative exposureCumulative exposureComplex survey designEffects of cumulative exposurePhysical activityObesity measuresAdaptive elastic-netChronic conditionsExposure to heavy metalsInteraction of heavy metalsWaist circumferenceTotal body fatNHANES cyclesU.S. adultsEpidemiological researchType 2 diabetes mellitusCorrelated heavy metalSmoking statusHigher BMISkinfold thicknessBone Lead Levels and Risk of Incident Primary Open-Angle Glaucoma: The VA Normative Aging Study
Wang W, Moroi S, Bakulski K, Mukherjee B, Weisskopf M, Schaumberg D, Sparrow D, Vokonas P, Hu H, Park S. Bone Lead Levels and Risk of Incident Primary Open-Angle Glaucoma: The VA Normative Aging Study. Environmental Health Perspectives 2018, 126: 087002. PMID: 30102601, PMCID: PMC6108844, DOI: 10.1289/ehp3442.Peer-Reviewed Original ResearchConceptsPrimary open-angle glaucomaIncident primary open-angle glaucomaRisk of primary open-angle glaucomaOpen-angle glaucomaHazard ratioIncident cases of POAGCases of primary open-angle glaucomaAsymmetric cup-to-disc ratioFollow-upPrimary open-angle glaucoma casesEtiology of primary open-angle glaucomaCup-to-disc ratioVisual field defectsCox proportional hazards regressionAssociated with hazard ratiosProportional hazards regressionOxidative stressEstimate hazard ratiosDisc hemorrhageOcular evaluationPatella leadField defectsCumulative lead doseProspective cohortSurvival curvesTemporal and geographic variation in the systemic treatment of advanced prostate cancer
Caram M, Estes J, Griggs J, Lin P, Mukherjee B. Temporal and geographic variation in the systemic treatment of advanced prostate cancer. BMC Cancer 2018, 18: 258. PMID: 29510667, PMCID: PMC5840834, DOI: 10.1186/s12885-018-4166-3.Peer-Reviewed Original ResearchConceptsMetastatic castration-resistant prostate cancerCastration-resistant prostate cancerFirst-line therapyProstate cancerSystemic treatmentFirst-lineSystemic treatment of advanced prostate cancerTreatment of metastatic castration-resistant prostate cancerTreatment of advanced prostate cancerResultsOur final analysisAdvanced prostate cancerFirst line therapyFood and Drug AdministrationNational insurance providerLine therapySequence of treatmentTreatment patternsDisease courseStudy cohortPrescription ratesPrescribed drugsDrug AdministrationIncreased survivalCancerTherapy
2017
Construction of environmental risk score beyond standard linear models using machine learning methods: application to metal mixtures, oxidative stress and cardiovascular disease in NHANES
Park S, Zhao Z, Mukherjee B. Construction of environmental risk score beyond standard linear models using machine learning methods: application to metal mixtures, oxidative stress and cardiovascular disease in NHANES. Environmental Health 2017, 16: 102. PMID: 28950902, PMCID: PMC5615812, DOI: 10.1186/s12940-017-0310-9.Peer-Reviewed Original ResearchConceptsEnvironmental risk scoreBayesian kernel machine regressionNational Health and Nutrition Examination SurveyHealth and Nutrition Examination SurveyRisk scoreAssociated with odds ratiosNutrition Examination SurveyAssociated with systolicExamination SurveyMulti-pollutant approachKernel machine regressionPollutant mixturesSD increaseEpidemiological researchDiastolic blood pressureMortality outcomesOdds ratioBayesian additive regression treesDisease endpointsHealth endpointsCumulative riskPositive associationEnvironmental exposuresIntermediate markersCardiovascular diseaseNeighborhood characteristics influence DNA methylation of genes involved in stress response and inflammation: The Multi-Ethnic Study of Atherosclerosis
Smith J, Zhao W, Wang X, Ratliff S, Mukherjee B, Kardia S, Liu Y, Roux A, Needham B. Neighborhood characteristics influence DNA methylation of genes involved in stress response and inflammation: The Multi-Ethnic Study of Atherosclerosis. Epigenetics 2017, 12: 662-673. PMID: 28678593, PMCID: PMC5687339, DOI: 10.1080/15592294.2017.1341026.Peer-Reviewed Original ResearchConceptsMulti-Ethnic Study of AtherosclerosisMulti-Ethnic StudyStudy of AtherosclerosisSocioeconomic disadvantageIndividual-level socioeconomic factorsEtiology of health disparitiesAssociated with poor health outcomesPopulation-based sample of US adultsSocioeconomic factorsNeighborhood conditionsNeighborhood socioeconomic disadvantageSample of US adultsNeighborhood social environmentHigher socioeconomic disadvantagePoor health outcomesIndividual socioeconomic factorsPopulation-based sampleDimensions of neighborhood contextHealth disparitiesInfluence methylation levelsHealth outcomesUS adultsSocial environmentDisadvantaged neighborhoodsNeighborhood characteristics