Central IKKβ inhibition prevents air pollution mediated peripheral inflammation and exaggeration of type II diabetes
Liu C, Fonken L, Wang A, Maiseyeu A, Bai Y, Wang T, Maurya S, Ko Y, Periasamy M, Dvonch T, Morishita M, Brook R, Harkema J, Ying Z, Mukherjee B, Sun Q, Nelson R, Rajagopalan S. Central IKKβ inhibition prevents air pollution mediated peripheral inflammation and exaggeration of type II diabetes. Particle And Fibre Toxicology 2014, 11: 53. PMID: 25358444, PMCID: PMC4226918, DOI: 10.1186/s12989-014-0053-5.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, MonoclonalAnti-Inflammatory AgentsBenzamidesBlood GlucoseDiabetes Mellitus, Type 2Disease Models, AnimalEnergy MetabolismHypothalamusI-kappa B KinaseInflammationInfliximabInhalation ExposureInjections, IntraventricularInsulinInsulin ResistanceInterleukin-6MiceOxygen ConsumptionParticulate MatterProtein Kinase InhibitorsRisk AssessmentRNA, MessengerThermogenesisTime FactorsTumor Necrosis Factor-alphaNo effect of acute exposure to coarse particulate matter air pollution in a rural location on high-density lipoprotein function
Maiseyeu A, Yang H, Ramanathan G, Yin F, Bard R, Morishita M, Dvonch J, Wang L, Spino C, Mukherjee B, Badgeley M, Barajas-Espinosa A, Sun Q, Harkema J, Rajagopalan S, Araujo J, Brook R. No effect of acute exposure to coarse particulate matter air pollution in a rural location on high-density lipoprotein function. Inhalation Toxicology 2014, 26: 23-29. PMID: 24417404, PMCID: PMC4445365, DOI: 10.3109/08958378.2013.850761.Peer-Reviewed Original ResearchConceptsRural locationsParticulate matter air pollutionHDL dysfunctionHDL anti-oxidative capacityRandomized double-blind crossover studyDouble-blind crossover studyHDL functionHDL-mediated cholesterol efflux capacityParaoxonase activityFiltered airVascular protective functionCholesterol efflux capacityHigh-density lipoprotein (HDL) particlesMetrics of HDL functionHDL-mediated effluxConcentrated ambient particlesCrossover studyImpact of PMEfflux capacityPM exposureVenous bloodAnimal studiesHealthy humansCoarse PMWilcoxon test