2022
Biomarkers of Exposure to Phthalate Mixtures and Adverse Birth Outcomes in a Puerto Rico Birth Cohort
Cathey A, Watkins D, Rosario Z, Vélez C, Mukherjee B, Alshawabkeh A, Cordero J, Meeker J. Biomarkers of Exposure to Phthalate Mixtures and Adverse Birth Outcomes in a Puerto Rico Birth Cohort. Environmental Health Perspectives 2022, 130: 037009. PMID: 35333099, PMCID: PMC8953418, DOI: 10.1289/ehp8990.Peer-Reviewed Original ResearchConceptsSpontaneous preterm birthPreterm birthFetal sexGestational agePregnancy outcomesBirth outcomesBayesian kernel machine regressionPhthalate metabolitesRisk of early deliveryAssociated with increased odds of PTBOdds of preterm birthPhthalate mixtureReduced gestational ageIndividual phthalate metabolitesMeasures of birth weightAssociated with increased riskPhthalate metabolite mixturesAdverse birth outcomesAssociated with increased oddsPuerto Rico TestsiteEnvironmental risk scoreEarly deliveryBirth weightPregnancy cohortLongitudinal pregnancy cohort
2018
The associations between prenatal exposure to triclocarban, phenols and parabens with gestational age and birth weight in northern Puerto Rico
Aker A, Ferguson K, Rosario Z, Mukherjee B, Alshawabkeh A, Cordero J, Meeker J. The associations between prenatal exposure to triclocarban, phenols and parabens with gestational age and birth weight in northern Puerto Rico. Environmental Research 2018, 169: 41-51. PMID: 30412856, PMCID: PMC6347499, DOI: 10.1016/j.envres.2018.10.030.Peer-Reviewed Original ResearchConceptsAssociated with gestational ageGestational ageOdds of SGAInfant sexBirth outcomesStudy visitsVisit 1Odds of preterm birthOdds of LGAAssociated with adverse birth outcomesBirthweight z-scoreBiomarker concentrationsAdverse birth outcomesPuerto Rico TestsitePreterm birthPregnant womenBirth weightUrinary biomarker concentrationsExposure biomarkersLogistic regression modelsVisit 3SGADecreased oddsZ-scoreCalculate oddsAssociations between repeated ultrasound measures of fetal growth and biomarkers of maternal oxidative stress and inflammation in pregnancy
Ferguson K, Kamai E, Cantonwine D, Mukherjee B, Meeker J, McElrath T. Associations between repeated ultrasound measures of fetal growth and biomarkers of maternal oxidative stress and inflammation in pregnancy. American Journal Of Reproductive Immunology 2018, 80: e13017. PMID: 29984454, PMCID: PMC6160349, DOI: 10.1111/aji.13017.Peer-Reviewed Original ResearchConceptsAssociated with reduced fetal growthFetal growthAssociated with poorer childAdult health outcomesOxidative stress markersBirth cohort studyInterquartile rangeAssociated with head circumferenceRepeated-measures modelFetal weight z-scoreAssociated with fetal weightOxidative stressHealth outcomesStandard deviation decreaseWeight z-scoreStress markersSecondary analysisMaternal oxidative stressCohort studyZ-scoreFetal weightMaternal inflammationDeviation decreasePreterm birthHead circumference
2017
Environmental phenol associations with ultrasound and delivery measures of fetal growth
Ferguson K, Meeker J, Cantonwine D, Mukherjee B, Pace G, Weller D, McElrath T. Environmental phenol associations with ultrasound and delivery measures of fetal growth. Environment International 2017, 112: 243-250. PMID: 29294443, PMCID: PMC5899051, DOI: 10.1016/j.envint.2017.12.011.Peer-Reviewed Original ResearchMeSH KeywordsBirth WeightFemaleFetal DevelopmentHumansInfant, NewbornMaleMaternal ExposurePhenolPregnancyProspective StudiesConceptsInverse associationBirth weight z-scoreWeight z-scoreZ-scoreFetal weightInterquartile range differenceFetal growthBirth weightUltrasound estimationUltrasound estimation of fetal weightEstimation of fetal weightLIFECODES birth cohortStandard deviation decreaseEstimated fetal weightBirth cohortOutcome measuresInvestigate sex differencesWomen's HospitalPregnant womenStudy populationStudy visitsDeviation decreaseDelivery measuresPregnancyAssociationSubclinical Changes in Maternal Thyroid Function Parameters in Pregnancy and Fetal Growth
Johns L, Ferguson K, Cantonwine D, Mukherjee B, Meeker J, McElrath T. Subclinical Changes in Maternal Thyroid Function Parameters in Pregnancy and Fetal Growth. The Journal Of Clinical Endocrinology & Metabolism 2017, 103: 1349-1358. PMID: 29293986, PMCID: PMC6018657, DOI: 10.1210/jc.2017-01698.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAsymptomatic DiseasesBirth WeightCase-Control StudiesFemaleFetal DevelopmentHumansInfant, NewbornPregnancyPregnancy ComplicationsPremature BirthProspective StudiesSocioeconomic FactorsThyroid DiseasesThyroid Function TestsThyroid GlandThyroid HormonesThyroxineUltrasonography, PrenatalYoung AdultConceptsBirth weight z-scoreOvert thyroid diseaseThyroid function parametersWeight z-scoreFetal growthThyroid diseaseInverse associationPregnant womenMeasurements of estimated fetal weightSubclinical changesIndices of fetal growthCase-control study of preterm birthStudy of preterm birthZ-scoreAbnormal fetal growthMaternal thyroid functionWeeks of gestationInfluence fetal growthZ-score decreaseThyroid-stimulating hormoneProspective birth cohortCase-control studyFunction parametersFetal weightPreterm birth
2016
Urinary phthalate metabolite and bisphenol A associations with ultrasound and delivery indices of fetal growth
Ferguson K, Meeker J, Cantonwine D, Chen Y, Mukherjee B, McElrath T. Urinary phthalate metabolite and bisphenol A associations with ultrasound and delivery indices of fetal growth. Environment International 2016, 94: 531-537. PMID: 27320326, PMCID: PMC4980186, DOI: 10.1016/j.envint.2016.06.013.Peer-Reviewed Original ResearchConceptsActual fetal weightUrinary phthalate metabolitesPhthalate metabolitesFetal weightFetal growthDi-2-ethylhexyl phthalate metabolitesNon-anomalous singleton pregnanciesAssociated with decreased fetal growthConcentrations of phthalate metabolitesTime pointsExposure to di-2-ethylhexyl phthalateSingleton pregnanciesLongitudinal birth cohortFetal sexDi-2-ethylhexyl phthalateInterquartile range increaseCross-sectional associationsUltrasound scanPregnancyInverse associationMaternal exposureDelivery indexUrine samplesStandard deviation decreaseBirth cohort
2011
A Latent Variable Approach to Study Gene–Environment Interactions in the Presence of Multiple Correlated Exposures
Sánchez B, Kang S, Mukherjee B. A Latent Variable Approach to Study Gene–Environment Interactions in the Presence of Multiple Correlated Exposures. Biometrics 2011, 68: 466-476. PMID: 21955029, PMCID: PMC4405908, DOI: 10.1111/j.1541-0420.2011.01677.x.Peer-Reviewed Original ResearchMeSH KeywordsAnalysis of VarianceBiasBiometryBirth WeightCase-Control StudiesComputer SimulationEnvironmental ExposureEpidemiologic FactorsFemaleGene-Environment InteractionHumansInfant, NewbornIronLead PoisoningModels, StatisticalPregnancyPrenatal Exposure Delayed EffectsPrincipal Component AnalysisConceptsGene-environment interactionsGene-environmentEnvironmental epidemiologyCohort studyGene-environment dependenceBurden of multiple testingStudy gene-environment interactionsEnvironmental exposuresExposure dataEarly life exposuresLV frameworkG x E effectsHealth StudyCorrelated exposuresG x EDisease riskLife exposureMultiple testingFunction of environmental exposureE studyGenotype categoriesStudy of lead exposureBirth weightIron metabolism genesAdaptive trade-off