2024
Associations of maternal blood metal concentrations with plasma eicosanoids among pregnant women in Puerto Rico
Kim C, Cathey A, Park S, Watkins D, Mukherjee B, Rosario-Pabón Z, Vélez-Vega C, Alshawabkeh A, Cordero J, Meeker J. Associations of maternal blood metal concentrations with plasma eicosanoids among pregnant women in Puerto Rico. The Science Of The Total Environment 2024, 928: 172295. PMID: 38588744, DOI: 10.1016/j.scitotenv.2024.172295.Peer-Reviewed Original ResearchConceptsAdverse birth outcomesSex-specific associationsBirth outcomesBlood metal concentrationsMetal concentrationsPregnant womenInfant sexEicosanoid profileMetal exposurePlasma eicosanoidsWeeks of pregnancyDecreased concentrations of CdConcentrations of CdConcentrations of CuEffect modificationRegulating inflammatory responsesBirth cohortAssessed associationsAssociated with increased concentrationsPregnancy outcomesFemale fetusesEffect sizeInflammatory activitySignificant associationInflammatory response
2023
Adverse birth outcomes are associated with circulating matrix metalloproteinases among pregnant women in Puerto Rico
Kim C, Cathey A, Watkins D, Mukherjee B, Rosario-Pabón Z, Vélez-Vega C, Alshawabkeh A, Cordero J, Meeker J. Adverse birth outcomes are associated with circulating matrix metalloproteinases among pregnant women in Puerto Rico. Journal Of Reproductive Immunology 2023, 159: 103991. PMID: 37454540, PMCID: PMC10726844, DOI: 10.1016/j.jri.2023.103991.Peer-Reviewed Original ResearchConceptsBirth outcomesMatrix metalloproteinasesFetal sexPregnant womenFemale fetusesNewborn lengthVisit 3Associated with increased odds of preeclampsiaVisit 1Impact of matrix metalloproteinasesCustomized Luminex assayGestational diabetes mellitusOdds of preeclampsiaAdverse birth outcomesAssociated with increased oddsGestational ageHealthy pregnancyMale fetusesUterine remodelingLuminex assayLogistic regression modelsDiabetes mellitusStudy visitsInverse associationExtracellular matrix
2022
Biomarkers of Exposure to Phthalate Mixtures and Adverse Birth Outcomes in a Puerto Rico Birth Cohort
Cathey A, Watkins D, Rosario Z, Vélez C, Mukherjee B, Alshawabkeh A, Cordero J, Meeker J. Biomarkers of Exposure to Phthalate Mixtures and Adverse Birth Outcomes in a Puerto Rico Birth Cohort. Environmental Health Perspectives 2022, 130: 037009. PMID: 35333099, PMCID: PMC8953418, DOI: 10.1289/ehp8990.Peer-Reviewed Original ResearchConceptsSpontaneous preterm birthPreterm birthFetal sexGestational agePregnancy outcomesBirth outcomesBayesian kernel machine regressionPhthalate metabolitesRisk of early deliveryAssociated with increased odds of PTBOdds of preterm birthPhthalate mixtureReduced gestational ageIndividual phthalate metabolitesMeasures of birth weightAssociated with increased riskPhthalate metabolite mixturesAdverse birth outcomesAssociated with increased oddsPuerto Rico TestsiteEnvironmental risk scoreEarly deliveryBirth weightPregnancy cohortLongitudinal pregnancy cohortMaternal blood metal concentrations are associated with matrix metalloproteinases (MMPs) among pregnant women in Puerto Rico
Kim C, Cathey A, Watkins D, Mukherjee B, Rosario-Pabón Z, Vélez-Vega C, Alshawabkeh A, Cordero J, Meeker J. Maternal blood metal concentrations are associated with matrix metalloproteinases (MMPs) among pregnant women in Puerto Rico. Environmental Research 2022, 209: 112874. PMID: 35123972, PMCID: PMC10443181, DOI: 10.1016/j.envres.2022.112874.Peer-Reviewed Original ResearchMeSH KeywordsFemaleHumansMaleMaternal ExposureMatrix MetalloproteinasesMetals, HeavyPregnancyPuerto RicoConceptsBlood metal concentrationsAdverse birth outcomesMetal concentrationsAssociated with matrix metalloproteinasesMatrix metalloproteinasesBirth outcomesFetal sexHealthy pregnancyLinear mixed effects modelsUterine remodelingPregnant womenFemale fetusesExposure to heavy metalsHeavy metal exposureCustomized Luminex assayFetal sex effectLevels of inflammatory cytokinesTrimester of pregnancyBlood metal levelsMetal levelsHeavy metalsMetal exposureMeasured blood concentrationsLuminex assayMale fetusesMaternal urinary phthalate metabolites are associated with lipidomic signatures among pregnant women in Puerto Rico
Ashrap P, Aung M, Watkins D, Mukherjee B, Rosario-Pabón Z, Vélez-Vega C, Alshawabkeh A, Cordero J, Meeker J. Maternal urinary phthalate metabolites are associated with lipidomic signatures among pregnant women in Puerto Rico. Journal Of Exposure Science & Environmental Epidemiology 2022, 32: 384-391. PMID: 35075242, PMCID: PMC9124693, DOI: 10.1038/s41370-022-00410-3.Peer-Reviewed Original ResearchConceptsUrinary phthalate metabolitesPhthalate metabolitesPlasmenyl-phosphatidylcholinesPregnant womenPuerto Rico PROTECT cohortPhthalate exposureLipidomic profilesMaternal urinary phthalate metabolitesWeeks of pregnancyMetabolite biomarkersMetabolites of di-2-ethylhexyl phthalateChild health outcomesCirculating lipid concentrationsLipidomic markersShotgun lipidomicsFatty acid chainsLipidomic signaturePROTECT cohortLipid profileCell-to-cell signalingImpactThis studyPregnancyAcid chainsPlasma samplesHealth outcomesMaternal Metals/Metalloid Blood Levels Are Associated With Lipidomic Profiles Among Pregnant Women in Puerto Rico
Kim C, Ashrap P, Watkins D, Mukherjee B, Rosario-Pabón Z, Vélez-Vega C, Alshawabkeh A, Cordero J, Meeker J. Maternal Metals/Metalloid Blood Levels Are Associated With Lipidomic Profiles Among Pregnant Women in Puerto Rico. Frontiers In Public Health 2022, 9: 754706. PMID: 35096734, PMCID: PMC8790322, DOI: 10.3389/fpubh.2021.754706.Peer-Reviewed Original ResearchConceptsAdverse birth outcomesBlood levelsPlasmenyl-phosphatidylcholinesLipidomic profilesBirth outcomesPlasmenyl phosphatidylethanolamineWeeks of pregnancyPlasma lipidomic profilesMultiple comparisonsLipid sub-classesHeavy metal exposurePolyunsaturated fatty acidsPregnant womenShotgun lipidomicsMetal exposureImportant signaling pathwaysAssessed associationsBiomarker profilesAssociated with lipidEarly detectionBirth cohortDiagnostic toolExposure to manganeseSignaling pathwayFalse discovery rate
2021
Gestational Hormone Concentrations Are Associated With Timing of Delivery in a Fetal Sex-Dependent Manner
Cathey A, Watkins D, Rosario Z, Vega C, Mukherjee B, O’Neill M, Loch-Caruso R, Alshawabkeh A, Cordero J, Meeker J. Gestational Hormone Concentrations Are Associated With Timing of Delivery in a Fetal Sex-Dependent Manner. Frontiers In Endocrinology 2021, 12: 742145. PMID: 34603214, PMCID: PMC8479114, DOI: 10.3389/fendo.2021.742145.Peer-Reviewed Original ResearchConceptsTime of deliveryFetal sexBody mass indexGestational ageMaternal agePreterm premature rupture of membranesPre-pregnancy body mass indexHormone concentrationsFetal sex-specific effectsPremature rupture of membranesOverall preterm birthPreterm premature ruptureSpontaneous preterm laborRupture of membranesReduced gestational ageOdds of PTBTime of laborSignificant public health problemTobacco smoke exposureGestational hormonesSpontaneous PTBPreterm laborWeeks gestationPreterm birthLongitudinal birth cohortPerformance of urine, blood, and integrated metal biomarkers in relation to birth outcomes in a mixture setting
Ashrap P, Watkins D, Mukherjee B, Rosario-Pabón Z, Vélez-Vega C, Alshawabkeh A, Cordero J, Meeker J. Performance of urine, blood, and integrated metal biomarkers in relation to birth outcomes in a mixture setting. Environmental Research 2021, 200: 111435. PMID: 34097892, PMCID: PMC8403638, DOI: 10.1016/j.envres.2021.111435.Peer-Reviewed Original ResearchMeSH KeywordsBiomarkersCohort StudiesFemaleHumansInfant, NewbornMetalsPregnancyPremature BirthPuerto RicoConceptsEnvironmental risk scoreIntraclass correlation coefficientBirth outcomesBody mass indexWeighted quantile sumOdds ratio of preterm birthSecond-hand smoke exposurePre-pregnancy body mass indexOdds of preterm birthAssociated with birth outcomesIncreased odds of preterm birthPractice study designHealth effectsPreterm birthMaternal educationIncreased oddsOdds ratioSmoke exposureStudy designMaternal ageMass indexArea under the curveRisk scoreLogistic regressionConfidence intervalsIndividual and joint effects of phthalate metabolites on biomarkers of oxidative stress among pregnant women in Puerto Rico
Cathey A, Eaton J, Ashrap P, Watkins D, Rosario Z, Vega C, Alshawabkeh A, Cordero J, Mukherjee B, Meeker J. Individual and joint effects of phthalate metabolites on biomarkers of oxidative stress among pregnant women in Puerto Rico. Environment International 2021, 154: 106565. PMID: 33882432, PMCID: PMC9923976, DOI: 10.1016/j.envint.2021.106565.Peer-Reviewed Original ResearchMeSH KeywordsBayes TheoremBiomarkersFemaleHumansOxidative StressPhthalic AcidsPregnancyPregnant WomenPuerto RicoConceptsBayesian kernel machine regressionPhthalate metabolitesEnvironmental risk scoreBiomarkers of oxidative stressPregnant womenPhthalate mixtureBayesian kernel machine regression analysisEffects of phthalate metabolitesOxidative stressIndividual phthalate metabolitesLipid oxidative stressUrinary biomarker measurementsKernel machine regressionAdverse birth outcomesPuerto Rico TestsiteOxidative stress biomarkersChemical fractionationContamination threatLongitudinal birth cohortPhthalate compoundsLinear mixed effects modelsBirth outcomesOxidative stress mechanismsStudy visitsPhthalate exposurePsychosocial status modifies the effect of maternal blood metal and metalloid concentrations on birth outcomes
Ashrap P, Aker A, Watkins D, Mukherjee B, Rosario-Pabón Z, Vélez-Vega C, Alshawabkeh A, Cordero J, Meeker J. Psychosocial status modifies the effect of maternal blood metal and metalloid concentrations on birth outcomes. Environment International 2021, 149: 106418. PMID: 33548848, PMCID: PMC7897320, DOI: 10.1016/j.envint.2021.106418.Peer-Reviewed Original ResearchConceptsAdverse birth outcomesPsychosocial statusBirth outcomesBody mass indexPsychosocial stressPreterm birthOdds ratioAssociated with adverse birth outcomesPre-pregnancy body mass indexSecond-hand smoke exposurePrenatal psychosocial stressPregnant womenBlood metalsClusters of womenEffects of psychosocial stressPuerto Rico TestsiteIncreased odds ratioSocial supportPerceived stressMaternal educationAdverse associationOverall preterm birthLow birth weightSpontaneous preterm birthCohort study
2020
Maternal blood metal and metalloid concentrations in association with birth outcomes in Northern Puerto Rico
Ashrap P, Watkins D, Mukherjee B, Boss J, Richards M, Rosario Z, Vélez-Vega C, Alshawabkeh A, Cordero J, Meeker J. Maternal blood metal and metalloid concentrations in association with birth outcomes in Northern Puerto Rico. Environment International 2020, 138: 105606. PMID: 32179314, PMCID: PMC7198231, DOI: 10.1016/j.envint.2020.105606.Peer-Reviewed Original ResearchConceptsBayesian kernel machine regressionShorter gestational agePreterm birthGestational ageEnvironmental risk scoreBirth outcomesMetal concentrationsNon-essential metal(loid)sHigher risk of preterm birthRisk of preterm birthLow-level prenatal lead exposureInterquartile rangeOdds of preterm birthAssociated with higher risk of preterm birthRisk scoreEffects of metalsPredictors of birth outcomesAssociated with birth outcomesBayesian kernel machine regression modelsBirthweight z-scoreAssociated with adverse birth outcomesAssociated with higher riskAdverse birth outcomesKernel machine regressionPuerto Rico TestsitePredictors of urinary and blood Metal(loid) concentrations among pregnant women in Northern Puerto Rico
Ashrap P, Watkins D, Mukherjee B, Boss J, Richards M, Rosario Z, Vélez-Vega C, Alshawabkeh A, Cordero J, Meeker J. Predictors of urinary and blood Metal(loid) concentrations among pregnant women in Northern Puerto Rico. Environmental Research 2020, 183: 109178. PMID: 32007748, PMCID: PMC7167342, DOI: 10.1016/j.envres.2020.109178.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsArsenicChromiumFemaleHumansMaternal ExposureMetalsMetals, HeavyPregnancyPuerto RicoTrace ElementsConceptsBlood concentrations of CuTrace metal exposureConcentrations of CuExposure reduction strategiesBiomarkers of exposureBlood HgMetalloid exposureMetal exposureNorthern Puerto RicoBlood CdTrace metalsBlood PbRice consumptionExposure sourcesPuerto RicoMetal(loid)sMetal(loidExposure assessmentBiomarker variationsPbPublic waterZnFishMnMetal
2019
Interactions between chemicals and non-chemical stressors: The modifying effect of life events on the association between triclocarban, phenols and parabens with gestational length in a Puerto Rican cohort
Aker A, McConnell R, Loch-Caruso R, Park S, Mukherjee B, Rosario Z, Vélez-Vega C, Huerta-Montanez G, Alshawabkeh A, Cordero J, Meeker J. Interactions between chemicals and non-chemical stressors: The modifying effect of life events on the association between triclocarban, phenols and parabens with gestational length in a Puerto Rican cohort. The Science Of The Total Environment 2019, 708: 134719. PMID: 31785910, PMCID: PMC6957748, DOI: 10.1016/j.scitotenv.2019.134719.Peer-Reviewed Original ResearchConceptsLife eventsLinear regression modelsMultiple linear regression modelNegative life eventsPresence of negative life eventsPsychosocial stress measuresAdverse birth outcomesPregnancy cohort studyRegression modelsEffects of psychosocial stressPsychosocial factorsNon-chemical stressorsBirth outcomesEffects of life eventsCohort studyPsychosocial stressPositive LEsPositive life eventsExposure biomarkersSignificant modifiersPrenatal exposureSignificant interactionWomenAssociationRate of eventsA repeated measures study of phenol, paraben and Triclocarban urinary biomarkers and circulating maternal hormones during gestation in the Puerto Rico PROTECT cohort
Aker A, Ferguson K, Rosario Z, Mukherjee B, Alshawabkeh A, Calafat A, Cordero J, Meeker J. A repeated measures study of phenol, paraben and Triclocarban urinary biomarkers and circulating maternal hormones during gestation in the Puerto Rico PROTECT cohort. Environmental Health 2019, 18: 28. PMID: 30940137, PMCID: PMC6444601, DOI: 10.1186/s12940-019-0459-5.Peer-Reviewed Original ResearchConceptsUrinary biomarkersAssociated with adverse birth outcomesAdverse birth outcomesPregnant womenBirth outcomesAdverse outcomesSerum hormonesStudy visitsParaben biomarkersThyroid hormonesParaben exposurePercent changeHormoneBiomarker concentrationsMaternal hormonesBiomarkersOutcomesVisitsAssociationExposureGestationRandom interceptPregnancyThyroid
2018
The associations between prenatal exposure to triclocarban, phenols and parabens with gestational age and birth weight in northern Puerto Rico
Aker A, Ferguson K, Rosario Z, Mukherjee B, Alshawabkeh A, Cordero J, Meeker J. The associations between prenatal exposure to triclocarban, phenols and parabens with gestational age and birth weight in northern Puerto Rico. Environmental Research 2018, 169: 41-51. PMID: 30412856, PMCID: PMC6347499, DOI: 10.1016/j.envres.2018.10.030.Peer-Reviewed Original ResearchConceptsAssociated with gestational ageGestational ageOdds of SGAInfant sexBirth outcomesStudy visitsVisit 1Odds of preterm birthOdds of LGAAssociated with adverse birth outcomesBirthweight z-scoreBiomarker concentrationsAdverse birth outcomesPuerto Rico TestsitePreterm birthPregnant womenBirth weightUrinary biomarker concentrationsExposure biomarkersLogistic regression modelsVisit 3SGADecreased oddsZ-scoreCalculate odds
2014
Urinary Phthalate Metabolite Associations with Biomarkers of Inflammation and Oxidative Stress Across Pregnancy in Puerto Rico
Ferguson K, Cantonwine D, Rivera-González L, Loch-Caruso R, Mukherjee B, Del Toro L, Jiménez-Vélez B, Calafat A, Ye X, Alshawabkeh A, Cordero J, Meeker J. Urinary Phthalate Metabolite Associations with Biomarkers of Inflammation and Oxidative Stress Across Pregnancy in Puerto Rico. Environmental Science And Technology 2014, 48: 7018-7025. PMID: 24845688, PMCID: PMC4066910, DOI: 10.1021/es502076j.Peer-Reviewed Original ResearchConceptsMono-n-butyl phthalateBiomarkers of inflammationIL-10Prospective cohort study of pregnant womenDi-2-ethylhexyl phthalate metabolitesCohort study of pregnant womenIL-6Study of pregnant womenAssociated with increased IL-6Oxidative stressUrinary phthalate metabolitesC-reactive proteinProspective cohort studyAdverse birth outcomesMetabolites of di-2-ethylhexyl phthalateOxidative stress markersPreterm birthMetabolite associationsPregnant womenMono-n-butylDi-2-ethylhexyl phthalateOxidative stress biomarkersBirth outcomesTNF-aInflammation biomarkers
2013
Urinary phthalate metabolite concentrations among pregnant women in Northern Puerto Rico: Distribution, temporal variability, and predictors
Cantonwine D, Cordero J, Rivera-González L, Del Toro L, Ferguson K, Mukherjee B, Calafat A, Crespo N, Jiménez-Vélez B, Padilla I, Alshawabkeh A, Meeker J. Urinary phthalate metabolite concentrations among pregnant women in Northern Puerto Rico: Distribution, temporal variability, and predictors. Environment International 2013, 62: 1-11. PMID: 24161445, PMCID: PMC3874859, DOI: 10.1016/j.envint.2013.09.014.Peer-Reviewed Original ResearchConceptsMono-3-carboxypropyl phthalateMono-ethyl phthalateUrinary phthalate metabolite concentrationsMono-carboxyisooctyl phthalatePhthalate metabolite concentrationsPregnant womenMono-carboxyisononyl phthalatePhthalate metabolitesMono-2-ethylhexyl phthalatePhthalate biomarkersDetectable concentrations of phthalate metabolitesMono-2-ethyl-5-oxohexyl phthalateMetabolite concentrationsMono-2-ethyl-5-carboxypentyl phthalateConcentrations of phthalate metabolitesMono-2-ethyl-5-carboxypentylUrinary phthalate biomarkersMono-2-ethyl-5-hydroxyhexyl phthalateWomen of reproductive ageUrine samplesAssociated with phthalate exposureMono-isobutyl phthalateMono-n-butyl phthalateMono-benzyl phthalateIntraclass correlation coefficientDistribution, Variability, and Predictors of Urinary Concentrations of Phenols and Parabens among Pregnant Women in Puerto Rico
Meeker J, Cantonwine D, Rivera-González L, Ferguson K, Mukherjee B, Calafat A, Ye X, Del Toro L, Crespo-Hernández N, Jiménez-Vélez B, Alshawabkeh A, Cordero J. Distribution, Variability, and Predictors of Urinary Concentrations of Phenols and Parabens among Pregnant Women in Puerto Rico. Environmental Science And Technology 2013, 47: 3439-3447. PMID: 23469879, PMCID: PMC3638245, DOI: 10.1021/es400510g.Peer-Reviewed Original ResearchConceptsBenzophenone-3Bisphenol AConcentrations of bisphenol AConcentrations of triclosanPuerto RicoUrinary concentrations of triclosanNorthern Puerto RicoConcentration of phenolHuman exposureB-PbTriclosanIntraclass correlation coefficientFrequent detectionUrinary concentrationsMethyl parabenParabensPropyl parabenEndocrine-related diseasesPregnant womenReduce exposureButyl parabenWomen of reproductive agePuerto Rican pregnant womenConcentrationRico