2022
Exposure to heavy metals and hormone levels in midlife women: The Study of Women's Health Across the Nation (SWAN)
Wang X, Ding N, Harlow S, Randolph J, Mukherjee B, Gold E, Park S. Exposure to heavy metals and hormone levels in midlife women: The Study of Women's Health Across the Nation (SWAN). Environmental Pollution 2022, 317: 120740. PMID: 36436662, PMCID: PMC9897061, DOI: 10.1016/j.envpol.2022.120740.Peer-Reviewed Original ResearchConceptsUrinary metal concentrationsExposure to heavy metalsHeavy metalsMetal concentrationsStudy of Women's HealthAssociation of heavy metalsEnvironmental heavy metal exposureHeavy metal exposureSex hormone-binding globulinFollicle-stimulating hormoneWomen's HealthBayesian kernel machine regressionAssociated with E<sub>2</sub>, TMidlife womenKernel machine regressionMetal exposureSerum hormone levelsMetal mixturesHealth-related factorsNation Multi-Pollutant StudyCalculate percent changesCadmiumHormone levelsProspective cohort studyLinear mixed effects modelsBody mass index associates with amyotrophic lateral sclerosis survival and metabolomic profiles
Goutman S, Boss J, Iyer G, Habra H, Savelieff M, Karnovsky A, Mukherjee B, Feldman E. Body mass index associates with amyotrophic lateral sclerosis survival and metabolomic profiles. Muscle & Nerve 2022, 67: 208-216. PMID: 36321729, PMCID: PMC9957813, DOI: 10.1002/mus.27744.Peer-Reviewed Original ResearchMeSH KeywordsAmyotrophic Lateral SclerosisBody Mass IndexHumansMetabolomicsPrognosisProspective StudiesConceptsBody mass indexBody mass index trajectoriesMetabolomic profilesAmyotrophic lateral sclerosis survivalAmyotrophic lateral sclerosisAmyotrophic lateral sclerosis participantsMass indexBody mass index lossBody mass index trajectory groupsSelf-reported body heightParticipants lost weightShorter survivalProspective cohortSurvival associationsStudy entryMetabolomic networksGeneralized estimating equationsSymptom onsetBMI trendsWeight lossSurvivalBile acidsBody heightTrajectory groupsPotential mechanismsOccupational history associates with ALS survival and onset segment
Goutman S, Boss J, Godwin C, Mukherjee B, Feldman E, Batterman S. Occupational history associates with ALS survival and onset segment. Amyotrophic Lateral Sclerosis And Frontotemporal Degeneration 2022, 24: 219-229. PMID: 36193557, PMCID: PMC10067530, DOI: 10.1080/21678421.2022.2127324.Peer-Reviewed Original ResearchMeSH KeywordsAmyotrophic Lateral SclerosisFemaleHumansMaleMilitary PersonnelOccupational ExposureProspective StudiesRisk FactorsConceptsStandard Occupational ClassificationOccupational settingsOnset segmentSelf-reported occupational exposureAmyotrophic Lateral Sclerosis RegistrySelf-reported exposureExposure to particulate matterCervical onsetStandard Occupational Classification codesMultinomial logistic regression modelCox proportional hazards modelsLogistic regression modelsSymptom onset to diagnosisOccupational pesticide exposureProportional hazards modelAssociated with workMaintenance occupationsGrounds cleaningALS clinicALS participantsProspective cohortAdjusted modelsDiagnosis ageAmyotrophic lateral sclerosis participantsOccupational historyUnderstanding Baseline Physical Activity in Cardiac Rehabilitation Enrollees Using Mobile Health Technologies
Golbus J, Gupta K, Stevens R, Jeganathan V, Luff E, Boyden T, Mukherjee B, Klasnja P, Kheterpal S, Kohnstamm S, Nallamothu B. Understanding Baseline Physical Activity in Cardiac Rehabilitation Enrollees Using Mobile Health Technologies. Circulation Cardiovascular Quality And Outcomes 2022, 15: e009182. PMID: 35559648, PMCID: PMC9308648, DOI: 10.1161/circoutcomes.122.009182.Peer-Reviewed Original ResearchMeSH KeywordsAgedBiomedical TechnologyCardiac RehabilitationExerciseFemaleHumansMaleProspective StudiesTelemedicineConceptsBaseline physical activityMobile health technologyCardiac rehabilitationPhysical activityExercise minutesHealth technologiesWalking distanceRehabilitation indicatorsModerate-risk patientsAssociated with daily step countsPhysical activity of patientsDaily step countCardiac rehabilitation programMobile health interventionsInitiate cardiac rehabilitationPatient-level featuresActivity of patientsMultivariate linear regressionStep countsUsual careRehabilitation programHealth interventionsAssociated with ageWear timePersonal carePer- and polyfluoroalkyl substances and incident diabetes in midlife women: the Study of Women’s Health Across the Nation (SWAN)
Park S, Wang X, Ding N, Karvonen-Gutierrez C, Calafat A, Herman W, Mukherjee B, Harlow S. Per- and polyfluoroalkyl substances and incident diabetes in midlife women: the Study of Women’s Health Across the Nation (SWAN). Diabetologia 2022, 65: 1157-1168. PMID: 35399113, PMCID: PMC9177697, DOI: 10.1007/s00125-022-05695-5.Peer-Reviewed Original ResearchMeSH KeywordsDiabetes MellitusEnvironmental PollutantsFemaleFluorocarbonsGlucoseHumansProspective StudiesWomen's HealthConceptsStudy of Women's HealthIncident diabetesWomen's HealthPolyfluoroalkyl substancesDiabetes riskMidlife womenSelf-reported diabetesTotal energy intakeProspective cohort studyIncreased diabetes riskCox proportional hazards modelsPhysical activityGlucose-lowering medicationsProportional hazards modelResultsAfter adjustmentNation Multi-Pollutant StudyBottom tertileSmoking statusHighest tertileAlcohol consumptionDiabetes-free womenFollow-up visitG-computationQuantile-based g-computationCohort studyMetals and risk of incident metabolic syndrome in a prospective cohort of midlife women in the United States
Wang X, Karvonen-Gutierrez C, Herman W, Mukherjee B, Park S. Metals and risk of incident metabolic syndrome in a prospective cohort of midlife women in the United States. Environmental Research 2022, 210: 112976. PMID: 35202625, PMCID: PMC9869389, DOI: 10.1016/j.envres.2022.112976.Peer-Reviewed Original ResearchConceptsEnvironmental risk scoreCohort of midlife womenIncident MetSMidlife womenHazard ratioRisk of incident MetSRisk of incident metabolic syndromeProspective cohortStudy of Women's HealthFree of MetSRisk of cardiometabolic diseasesIncident metabolic syndromeMetabolic syndromeImpaired fasting glucoseCox proportional hazards modelsHigh-density lipoprotein cholesterolHigh blood pressureMetS incidenceWomen's HealthProportional hazards modelAbdominal obesityNation Multi-Pollutant StudyDevelopment of metabolic syndromeCardiometabolic diseasesHigh triglycerides
2021
Per- and Polyfluoroalkyl Substances and Hormone Levels During the Menopausal Transition
Harlow S, Hood M, Ding N, Mukherjee B, Calafat A, Randolph J, Gold E, Park S. Per- and Polyfluoroalkyl Substances and Hormone Levels During the Menopausal Transition. The Journal Of Clinical Endocrinology & Metabolism 2021, 106: e4427-e4437. PMID: 34181018, PMCID: PMC8677593, DOI: 10.1210/clinem/dgab476.Peer-Reviewed Original ResearchConceptsMidlife womenSex hormone-binding globulinFollicle-stimulating hormoneInverse associationStudy of Women's HealthPositive associationMenopausal transitionBody mass indexReproductive ageWomen's HealthSignificant linear trendNo significant associationNulliparous womenLinear mixed modelsSmoking statusYears of ageMass indexHormone-binding globulinMenopausal statusLongitudinal serum concentrationsSignificant associationSerum PFAS concentrationsMidlifeWomenPolyfluoroalkyl substances
2019
Urinary concentrations of phenols in association with biomarkers of oxidative stress in pregnancy: Assessment of effects independent of phthalates
Ferguson K, Lan Z, Yu Y, Mukherjee B, McElrath T, Meeker J. Urinary concentrations of phenols in association with biomarkers of oxidative stress in pregnancy: Assessment of effects independent of phthalates. Environment International 2019, 131: 104903. PMID: 31288179, PMCID: PMC6728185, DOI: 10.1016/j.envint.2019.104903.Peer-Reviewed Original ResearchConceptsUrinary phthalate metabolitesOxidative stress biomarkersNon-null associationsPhthalate metabolitesBiomarkers of oxidative stressInterquartile rangeBenzophenone-3Associated with increasesOutcome biomarkersIncreased maternal oxidative stressStress biomarkersExposure to environmental phenolsOxidative stressReduced fetal growthUrinary oxidative stress biomarkersMaternal oxidative stressEffect estimatesAdaptive elastic net modelStudy populationPreterm birthFetal growthConcentration of phenolUrinary phenolPregnancyUrinary concentrationsAssociation Between Life Purpose and Mortality Among US Adults Older Than 50 Years
Alimujiang A, Wiensch A, Boss J, Fleischer N, Mondul A, McLean K, Mukherjee B, Pearce C. Association Between Life Purpose and Mortality Among US Adults Older Than 50 Years. JAMA Network Open 2019, 2: e194270. PMID: 31125099, PMCID: PMC6632139, DOI: 10.1001/jamanetworkopen.2019.4270.Peer-Reviewed Original ResearchConceptsHealth and Retirement StudyCause-specific mortalityAll-causeHealth outcomesUS adultsHealth and Retirement Study participantsCohort study of US adultsCause-specific mortality analysesInterview periodStudy of US adultsInfluence health outcomesAssociated with all-cause mortalityLife purposeCohort study sampleWeighted Cox proportional hazards modelsNational cohort studyPurpose in lifeQuality of lifeAll-cause mortalityCox proportional hazards modelsEnhance overall qualityAssociated with decreased mortalityProportional hazards modelRetirement StudyMortality associations
2018
Bone Lead Levels and Risk of Incident Primary Open-Angle Glaucoma: The VA Normative Aging Study
Wang W, Moroi S, Bakulski K, Mukherjee B, Weisskopf M, Schaumberg D, Sparrow D, Vokonas P, Hu H, Park S. Bone Lead Levels and Risk of Incident Primary Open-Angle Glaucoma: The VA Normative Aging Study. Environmental Health Perspectives 2018, 126: 087002. PMID: 30102601, PMCID: PMC6108844, DOI: 10.1289/ehp3442.Peer-Reviewed Original ResearchMeSH KeywordsAgedBostonGlaucoma, Open-AngleHumansIncidenceLeadMaleMassachusettsMiddle AgedPatellaProspective StudiesRisk FactorsTibiaConceptsPrimary open-angle glaucomaIncident primary open-angle glaucomaRisk of primary open-angle glaucomaOpen-angle glaucomaHazard ratioIncident cases of POAGCases of primary open-angle glaucomaAsymmetric cup-to-disc ratioFollow-upPrimary open-angle glaucoma casesEtiology of primary open-angle glaucomaCup-to-disc ratioVisual field defectsCox proportional hazards regressionAssociated with hazard ratiosProportional hazards regressionOxidative stressEstimate hazard ratiosDisc hemorrhageOcular evaluationPatella leadField defectsCumulative lead doseProspective cohortSurvival curvesUsing community health workers to refer pregnant women and young children to health care facilities in rural West Bengal, India: A prospective cohort study
Wagner A, Xia L, Ghosh A, Datta S, Pandey P, Santra S, Chattopadhyay S, Nandi U, Mazumder T, Joshi S, Pal J, Mukherjee B. Using community health workers to refer pregnant women and young children to health care facilities in rural West Bengal, India: A prospective cohort study. PLOS ONE 2018, 13: e0199607. PMID: 29928057, PMCID: PMC6013192, DOI: 10.1371/journal.pone.0199607.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultChild, PreschoolCommunity Health WorkersDeveloping CountriesDevelopmental DisabilitiesFeasibility StudiesFemaleFollow-Up StudiesHumansIndiaInfantLongitudinal StudiesMaleMothersPatient Acceptance of Health CarePregnancyPregnancy ComplicationsProspective StudiesReferral and ConsultationRisk FactorsRural PopulationVulnerable PopulationsYoung AdultConceptsCommunity health workersCommunity health worker visitsHealth behaviorsMothers of young childrenHealth careHealth workersPregnant womenHealth of vulnerable populationsOverall health behaviorsPositive health outcomesPreventive health careRisk of pregnancy-related complicationsRural areasHealth care facilitiesEarly childhood developmental delaysMothers of childrenRural areas of IndiaYoung childrenChildhood developmental delayPregnancy-related complicationsHealth outcomesCare facilitiesMedical characteristicsRe-contactedCare
2017
Environmental phenol associations with ultrasound and delivery measures of fetal growth
Ferguson K, Meeker J, Cantonwine D, Mukherjee B, Pace G, Weller D, McElrath T. Environmental phenol associations with ultrasound and delivery measures of fetal growth. Environment International 2017, 112: 243-250. PMID: 29294443, PMCID: PMC5899051, DOI: 10.1016/j.envint.2017.12.011.Peer-Reviewed Original ResearchMeSH KeywordsBirth WeightFemaleFetal DevelopmentHumansInfant, NewbornMaleMaternal ExposurePhenolPregnancyProspective StudiesConceptsInverse associationBirth weight z-scoreWeight z-scoreZ-scoreFetal weightInterquartile range differenceFetal growthBirth weightUltrasound estimationUltrasound estimation of fetal weightEstimation of fetal weightLIFECODES birth cohortStandard deviation decreaseEstimated fetal weightBirth cohortOutcome measuresInvestigate sex differencesWomen's HospitalPregnant womenStudy populationStudy visitsDeviation decreaseDelivery measuresPregnancyAssociationSubclinical Changes in Maternal Thyroid Function Parameters in Pregnancy and Fetal Growth
Johns L, Ferguson K, Cantonwine D, Mukherjee B, Meeker J, McElrath T. Subclinical Changes in Maternal Thyroid Function Parameters in Pregnancy and Fetal Growth. The Journal Of Clinical Endocrinology & Metabolism 2017, 103: 1349-1358. PMID: 29293986, PMCID: PMC6018657, DOI: 10.1210/jc.2017-01698.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAsymptomatic DiseasesBirth WeightCase-Control StudiesFemaleFetal DevelopmentHumansInfant, NewbornPregnancyPregnancy ComplicationsPremature BirthProspective StudiesSocioeconomic FactorsThyroid DiseasesThyroid Function TestsThyroid GlandThyroid HormonesThyroxineUltrasonography, PrenatalYoung AdultConceptsBirth weight z-scoreOvert thyroid diseaseThyroid function parametersWeight z-scoreFetal growthThyroid diseaseInverse associationPregnant womenMeasurements of estimated fetal weightSubclinical changesIndices of fetal growthCase-control study of preterm birthStudy of preterm birthZ-scoreAbnormal fetal growthMaternal thyroid functionWeeks of gestationInfluence fetal growthZ-score decreaseThyroid-stimulating hormoneProspective birth cohortCase-control studyFunction parametersFetal weightPreterm birth
2016
Increasing efficiency for estimating treatment–biomarker interactions with historical data
Boonstra P, Taylor J, Mukherjee B. Increasing efficiency for estimating treatment–biomarker interactions with historical data. Statistical Methods In Medical Research 2016, 25: 2959-2971. PMID: 24855118, PMCID: PMC5450810, DOI: 10.1177/0962280214535370.Peer-Reviewed Original ResearchMeSH KeywordsBiomarkersClinical Trials, Phase II as TopicHumansMaleProspective StudiesProstatic Neoplasms, Castration-ResistantSample SizeUrinary phthalate metabolite and bisphenol A associations with ultrasound and delivery indices of fetal growth
Ferguson K, Meeker J, Cantonwine D, Chen Y, Mukherjee B, McElrath T. Urinary phthalate metabolite and bisphenol A associations with ultrasound and delivery indices of fetal growth. Environment International 2016, 94: 531-537. PMID: 27320326, PMCID: PMC4980186, DOI: 10.1016/j.envint.2016.06.013.Peer-Reviewed Original ResearchConceptsActual fetal weightUrinary phthalate metabolitesPhthalate metabolitesFetal weightFetal growthDi-2-ethylhexyl phthalate metabolitesNon-anomalous singleton pregnanciesAssociated with decreased fetal growthConcentrations of phthalate metabolitesTime pointsExposure to di-2-ethylhexyl phthalateSingleton pregnanciesLongitudinal birth cohortFetal sexDi-2-ethylhexyl phthalateInterquartile range increaseCross-sectional associationsUltrasound scanPregnancyInverse associationMaternal exposureDelivery indexUrine samplesStandard deviation decreaseBirth cohort
2015
Extreme Air Pollution Conditions Adversely Affect Blood Pressure and Insulin Resistance
Brook R, Sun Z, Brook J, Zhao X, Ruan Y, Yan J, Mukherjee B, Rao X, Duan F, Sun L, Liang R, Lian H, Zhang S, Fang Q, Gu D, Sun Q, Fan Z, Rajagopalan S. Extreme Air Pollution Conditions Adversely Affect Blood Pressure and Insulin Resistance. Hypertension 2015, 67: 77-85. PMID: 26573709, PMCID: PMC4830086, DOI: 10.1161/hypertensionaha.115.06237.Peer-Reviewed Original ResearchConceptsFine particulate matterParticulate matterAmbient fine particulate matterSD increaseAssociated with worsening insulin resistanceBlack carbon levelsBlack carbon exposurePublic health warningsAir pollutionBeijing metropolitan areaBlack carbonHealth warningsAssociated with rangeCardiometabolic healthCarbon levelsDiastolic blood pressureExposure windowsCardiometabolic diseasesHealth effectsNonsmoking adultsMetabolic syndromeDeveloping world todayCarbon exposureSystolic blood pressure elevationHealthUrinary Bisphenol A Levels during Pregnancy and Risk of Preterm Birth
Cantonwine D, Ferguson K, Mukherjee B, McElrath T, Meeker J. Urinary Bisphenol A Levels during Pregnancy and Risk of Preterm Birth. Environmental Health Perspectives 2015, 123: 895-901. PMID: 25815860, PMCID: PMC4559950, DOI: 10.1289/ehp.1408126.Peer-Reviewed Original ResearchConceptsRisk of preterm birthPreterm birthBisphenol A exposurePreterm premature rupture of membranesClinical classificationClassification of preterm birthSubcategories of preterm birthPremature rupture of membranesBisphenol A levelsCases of preterm birthAssociated with preterm birthSpontaneous preterm laborPreterm premature ruptureRupture of membranesSpontaneous preterm birthIntrauterine growth restrictionNested case-control studyProspective birth cohort studyUrinary bisphenol ACase-control studyAssociated with increased oddsA levelsTertiary teaching hospitalBirth cohort studyDelivered preterm
2014
Repeated measures of urinary oxidative stress biomarkers during pregnancy and preterm birth
Ferguson K, McElrath T, Chen Y, Loch-Caruso R, Mukherjee B, Meeker J. Repeated measures of urinary oxidative stress biomarkers during pregnancy and preterm birth. American Journal Of Obstetrics And Gynecology 2014, 212: 208.e1-208.e8. PMID: 25111586, PMCID: PMC4312513, DOI: 10.1016/j.ajog.2014.08.007.Peer-Reviewed Original ResearchConceptsSpontaneous preterm birthPreterm birthAssociated with increased odds of spontaneous preterm birthCases of spontaneous preterm birthOdds of spontaneous preterm birthPathways to preterm birthMechanisms of preterm birthNested case-control studyLevels of 8-isoprostaneOxidative stressUrinary biomarkers of oxidative stressConcentrations of 8-isoprostaneUrinary oxidative stress biomarkersLevels of 8-OHdGMaternal oxidative stressCase-control studyProspective birth cohortUrinary 8-OHdG concentrationsAssociated with increased oddsInvestigate oxidative stressDelivered pretermBiomarkers of oxidative stressPlacental originUrinary concentrations of 8-isoprostanePretermVariability in urinary phthalate metabolite levels across pregnancy and sensitive windows of exposure for the risk of preterm birth
Ferguson K, McElrath T, Ko Y, Mukherjee B, Meeker J. Variability in urinary phthalate metabolite levels across pregnancy and sensitive windows of exposure for the risk of preterm birth. Environment International 2014, 70: 118-124. PMID: 24934852, PMCID: PMC4104181, DOI: 10.1016/j.envint.2014.05.016.Peer-Reviewed Original ResearchConceptsAdjusted odds ratiosUrinary phthalate metabolite levelsPreterm birthPhthalate metabolite levelsOdds ratioOdds of preterm birthAssociated with increased odds of preterm birthIncreased risk of delivering pretermCases of preterm birthWeeks of completed gestationRisk of delivering pretermAssociated with increased oddsMetabolite levelsPresentation of preeclampsiaSignificant public health problemSpontaneous preterm birthIntrauterine growth restrictionLongitudinal birth cohortPhthalate metabolite concentrationsPublic health problemBirth outcomesBirth cohortGrowth restrictionThird trimesterPregnant womenPersonal Black Carbon Exposure Influences Ambulatory Blood Pressure
Zhao X, Sun Z, Ruan Y, Yan J, Mukherjee B, Yang F, Duan F, Sun L, Liang R, Lian H, Zhang S, Fang Q, Gu D, Brook J, Sun Q, Brook R, Rajagopalan S, Fan Z. Personal Black Carbon Exposure Influences Ambulatory Blood Pressure. Hypertension 2014, 63: 871-877. PMID: 24420543, PMCID: PMC4445364, DOI: 10.1161/hypertensionaha.113.02588.Peer-Reviewed Original ResearchConceptsPersonal black carbonAir pollutionBlack carbonBeijing Municipal Environmental Monitoring CenterFine particulate matter concentrationsCombustion-related air pollutionFine particulate matterAmbulatory blood pressureEnvironmental Monitoring CenterParticulate matter concentrationsBlood pressureHigh air pollutionReduce air pollutionMm HgLow frequency to high frequency ratioPublic health effectsParticulate matterTwenty-four-hour ambulatory blood pressureExposure to high levelsMatter concentrationSystolic blood pressureDiastolic blood pressurePollutionBlood pressure effectsGeneralized linear model