2011
High Risk of Colorectal and Endometrial Cancer in Ashkenazi Families With the MSH2 A636P Founder Mutation
Mukherjee B, Rennert G, Ahn J, Dishon S, Lejbkowicz F, Rennert H, Shiovitz S, Moreno V, Gruber S. High Risk of Colorectal and Endometrial Cancer in Ashkenazi Families With the MSH2 A636P Founder Mutation. Gastroenterology 2011, 140: 1919-1926. PMID: 21419771, PMCID: PMC4835182, DOI: 10.1053/j.gastro.2011.02.071.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAgedAged, 80 and overCase-Control StudiesColorectal Neoplasms, Hereditary NonpolyposisEndometrial NeoplasmsFemaleFounder EffectGene FrequencyGenetic Predisposition to DiseaseGenetic TestingHeredityHumansIsraelJewsLikelihood FunctionsMaleMass ScreeningMiddle AgedMutationMutS Homolog 2 ProteinPedigreePenetrancePhenotypeProportional Hazards ModelsRegistriesRisk AssessmentRisk FactorsSex FactorsYoung AdultConceptsRisk of colorectal cancerHazard ratioColorectal cancerCumulative riskPopulation-basedLifetime risk of colorectal cancerCumulative risk of colorectal cancerEstimates of colorectal cancerAge-specific cumulative riskHigh risk of colorectalCases of colorectal cancerModified segregation analysisRisk of colorectalClinical genetics servicesClinic-based sampleEndometrial cancerRisk of ECCase-control studyGenetic servicesLynch syndromeCancer screeningEC riskLifetime riskAshkenazi familiesEstimated penetrance
2010
Risk of colorectal cancer in self‐reported inflammatory bowel disease and modification of risk by statin and NSAID use
Samadder N, Mukherjee B, Huang S, Ahn J, Rennert H, Greenson J, Rennert G, Gruber S. Risk of colorectal cancer in self‐reported inflammatory bowel disease and modification of risk by statin and NSAID use. Cancer 2010, 117: 1640-1648. PMID: 21472711, PMCID: PMC3117060, DOI: 10.1002/cncr.25731.Peer-Reviewed Original ResearchConceptsRisk of colorectal cancerAssociated with reduced risk of colorectal cancerHistory of inflammatory bowel diseaseRisk of inflammatory bowel diseaseAssociated with reduced riskLong-term statin useColorectal cancerMolecular Epidemiology of Colorectal Cancer studyPersonal history of inflammatory bowel diseaseIncreased risk of CRCReduced risk of colorectal cancerRelative riskIBD-associated colorectal cancerIncident colorectal cancerNonsteroidal anti-inflammatory drugsUnconditional logistic regressionNonsteroidal anti-inflammatory drug useStatin useModification of riskReduced riskInflammatory bowel diseaseColorectal cancer studyIn-person interviewsNon-IBD colorectal cancersCase-control study
2009
Calculation of Risk of Colorectal and Endometrial Cancer Among Patients With Lynch Syndrome
Stoffel E, Mukherjee B, Raymond V, Tayob N, Kastrinos F, Sparr J, Wang F, Bandipalliam P, Syngal S, Gruber S. Calculation of Risk of Colorectal and Endometrial Cancer Among Patients With Lynch Syndrome. Gastroenterology 2009, 137: 1621-1627. PMID: 19622357, PMCID: PMC2767441, DOI: 10.1053/j.gastro.2009.07.039.Peer-Reviewed Original ResearchConceptsRisk of colorectal cancerCumulative risk of colorectal cancerHazard ratioColorectal cancerCumulative riskLifetime risk of colorectal cancerMismatch repair gene mutation carriersEstimates of colorectal cancerAge-specific cumulative riskMismatch repair gene mutationsEstimates of lifetime riskCancer genetics clinicsCases of colorectal cancerModified segregation analysisRisk of colorectalColorectal cancer riskHereditary colorectal cancerEndometrial cancerGene mutation carriersRepair gene mutationsRisk of ECOverestimation of penetrationFirst-degree relativesLynch syndromeCancer surveillanceM2006 Elevated Risk of Colorectal Cancer in Inflammatory Bowel Disease and Modification of Risk By Statin Use: A Population-Based Case-Control Study
Samadder N, Huang S, Mukherjee B, Rennert G, Gruber S. M2006 Elevated Risk of Colorectal Cancer in Inflammatory Bowel Disease and Modification of Risk By Statin Use: A Population-Based Case-Control Study. Gastroenterology 2009, 136: a-465. DOI: 10.1016/s0016-5085(09)62140-5.Peer-Reviewed Original Research