2024
Improving prediction models of amyotrophic lateral sclerosis (ALS) using polygenic, pre-existing conditions, and survey-based risk scores in the UK Biobank
Jin W, Boss J, Bakulski K, Goutman S, Feldman E, Fritsche L, Mukherjee B. Improving prediction models of amyotrophic lateral sclerosis (ALS) using polygenic, pre-existing conditions, and survey-based risk scores in the UK Biobank. Journal Of Neurology 2024, 271: 6923-6934. PMID: 39249108, DOI: 10.1007/s00415-024-12644-2.Peer-Reviewed Original ResearchPolygenic risk scoresRisk scorePre-existing conditionsPhenome-wide association studyControls of European descentPhenotype risk scoreUK Biobank dataAmyotrophic lateral sclerosis riskRisk score distributionIncreased ALS riskInfluence of environmental exposuresExposure-related factorsCombined risk scoreUK BiobankAmyotrophic lateral sclerosisBaseline demographic covariatesBiobank dataPRS-CSALS riskAmyotrophic lateral sclerosis diagnosisDiagnosis 1Demographic covariatesAssociation studiesEuropean descentMethodsUtilizing data
2023
Uncovering associations between pre-existing conditions and COVID-19 Severity: A polygenic risk score approach across three large biobanks
Fritsche L, Nam K, Du J, Kundu R, Salvatore M, Shi X, Lee S, Burgess S, Mukherjee B. Uncovering associations between pre-existing conditions and COVID-19 Severity: A polygenic risk score approach across three large biobanks. PLOS Genetics 2023, 19: e1010907. PMID: 38113267, PMCID: PMC10763941, DOI: 10.1371/journal.pgen.1010907.Peer-Reviewed Original ResearchConceptsPolygenic risk scoresMichigan Genomics InitiativeUK BiobankPre-existing conditionsPhenome-wide association studyAssociation studiesCohort-specific analysesPolygenic risk score approachUK Biobank cohortMeta-analysisIncreased risk of hospitalizationGenome-wide association studiesBody mass indexRisk of hospitalizationIdentified novel associationsRisk score approachCOVID-19 outcome dataCOVID-19 hospitalizationCOVID-19Mass indexRisk scoreBiobankCardiovascular conditionsCOVID-19 severityIncreased risk
2021
Understanding the Patterns of Serological Testing for COVID-19 Pre- and Post-Vaccination Rollout in Michigan
Zhao Z, Salerno S, Shi X, Lee S, Mukherjee B, Fritsche L. Understanding the Patterns of Serological Testing for COVID-19 Pre- and Post-Vaccination Rollout in Michigan. Journal Of Clinical Medicine 2021, 10: 4341. PMID: 34640359, PMCID: PMC8509702, DOI: 10.3390/jcm10194341.Peer-Reviewed Original ResearchNon-Hispanic black race/ethnicityRegional health centersEver-smoking statusHealth centersBlack race/ethnicityAssociated with ageCirculatory diseasesSARS-CoV-2 antibody testingMichigan MedicinePre-existing conditionsNeighborhood variablesCOVID-19SARS-CoV-2 antibodiesSARS-CoV-2Vaccinated individualsVaccine-induced immunityRespiratory diseaseIndividualsCOVID-19 infectionExploratory analysisLiver diseaseAgeSerological testsA Phenome-Wide Association Study (PheWAS) of COVID-19 Outcomes by Race Using the Electronic Health Records Data in Michigan Medicine
Salvatore M, Gu T, Mack J, Sankar S, Patil S, Valley T, Singh K, Nallamothu B, Kheterpal S, Lisabeth L, Fritsche L, Mukherjee B. A Phenome-Wide Association Study (PheWAS) of COVID-19 Outcomes by Race Using the Electronic Health Records Data in Michigan Medicine. Journal Of Clinical Medicine 2021, 10: 1351. PMID: 33805886, PMCID: PMC8037108, DOI: 10.3390/jcm10071351.Peer-Reviewed Original ResearchPhenome-wide association studyCOVID-19 outcomesIntensive care unitAssociation studiesNon-Hispanic blacksNon-Hispanic whitesAcademic medical centerAssociated with hospitalizationHealthcare deliveryAssociated with mortalityMedicine backgroundPre-existing conditionsMedical phenomeDisease preventionVulnerable populationsPulmonary heart diseaseTargeted screeningMental disordersCOVID-19Associated with intensive care unitMedical CenterRecord DataCare unitGenitourinary conditionsHeart disease