2022
Biomarkers of Exposure to Phthalate Mixtures and Adverse Birth Outcomes in a Puerto Rico Birth Cohort
Cathey A, Watkins D, Rosario Z, Vélez C, Mukherjee B, Alshawabkeh A, Cordero J, Meeker J. Biomarkers of Exposure to Phthalate Mixtures and Adverse Birth Outcomes in a Puerto Rico Birth Cohort. Environmental Health Perspectives 2022, 130: 037009. PMID: 35333099, PMCID: PMC8953418, DOI: 10.1289/ehp8990.Peer-Reviewed Original ResearchConceptsSpontaneous preterm birthPreterm birthFetal sexGestational agePregnancy outcomesBirth outcomesBayesian kernel machine regressionPhthalate metabolitesRisk of early deliveryAssociated with increased odds of PTBOdds of preterm birthPhthalate mixtureReduced gestational ageIndividual phthalate metabolitesMeasures of birth weightAssociated with increased riskPhthalate metabolite mixturesAdverse birth outcomesAssociated with increased oddsPuerto Rico TestsiteEnvironmental risk scoreEarly deliveryBirth weightPregnancy cohortLongitudinal pregnancy cohortMediation by hormone concentrations on the associations between repeated measures of phthalate mixture exposure and timing of delivery
Cathey A, Aung M, Watkins D, Rosario Z, Vélez Vega C, Alshawabkeh A, Cordero J, Mukherjee B, Meeker J. Mediation by hormone concentrations on the associations between repeated measures of phthalate mixture exposure and timing of delivery. Journal Of Exposure Science & Environmental Epidemiology 2022, 32: 374-383. PMID: 34987188, PMCID: PMC9124667, DOI: 10.1038/s41370-021-00408-3.Peer-Reviewed Original ResearchConceptsSpontaneous preterm birthPreterm birthCorticotropin-releasing hormoneFetal sexMale fetusesEarly deliveryHormone concentrationsAssociated with earlier deliveryPhthalate exposurePhthalate mixtureReduced gestational ageTime of deliveryEnvironmental risk scoreGestational ageFemale fetusesUrinary phthalatesSex-specific analysesEndocrine-disrupting capabilitiesReleasing hormoneSerum hormonesFetusesRisk scoreSusceptible to endocrine disruptionBirth cohortHormone
2021
Hormone concentrations mediate the associations between exposure to phthalate mixtures and preterm birth
Cathey A, Aung M, Watkins D, Rosario Z, Vélez Vega C, Alshawabkeh A, Cordero J, Mukherjee B, Meeker J. Hormone concentrations mediate the associations between exposure to phthalate mixtures and preterm birth. ISEE Conference Abstracts 2021, 2021 DOI: 10.1289/isee.2021.p-299.Peer-Reviewed Original ResearchIndividual and joint effects of phthalate metabolites on biomarkers of oxidative stress among pregnant women in Puerto Rico
Cathey A, Eaton J, Ashrap P, Watkins D, Rosario Z, Vega C, Alshawabkeh A, Cordero J, Mukherjee B, Meeker J. Individual and joint effects of phthalate metabolites on biomarkers of oxidative stress among pregnant women in Puerto Rico. Environment International 2021, 154: 106565. PMID: 33882432, PMCID: PMC9923976, DOI: 10.1016/j.envint.2021.106565.Peer-Reviewed Original ResearchConceptsBayesian kernel machine regressionPhthalate metabolitesEnvironmental risk scoreBiomarkers of oxidative stressPregnant womenPhthalate mixtureBayesian kernel machine regression analysisEffects of phthalate metabolitesOxidative stressIndividual phthalate metabolitesLipid oxidative stressUrinary biomarker measurementsKernel machine regressionAdverse birth outcomesPuerto Rico TestsiteOxidative stress biomarkersChemical fractionationContamination threatLongitudinal birth cohortPhthalate compoundsLinear mixed effects modelsBirth outcomesOxidative stress mechanismsStudy visitsPhthalate exposure