Prenatal exposure to per- and polyfluoroalkyl substances (PFAS) and their influence on inflammatory biomarkers in pregnancy: Findings from the LIFECODES cohort
Siwakoti R, Harris S, Ferguson K, Hao W, Cantonwine D, Mukherjee B, McElrath T, Meeker J. Prenatal exposure to per- and polyfluoroalkyl substances (PFAS) and their influence on inflammatory biomarkers in pregnancy: Findings from the LIFECODES cohort. Environment International 2024, 194: 109145. PMID: 39550829, DOI: 10.1016/j.envint.2024.109145.Peer-Reviewed Original ResearchC-reactive proteinNested case-control study of preterm birthCase-control study of preterm birthInflammatory biomarkersIL-10TNF-aInterquartile range increaseNested case-control studyStudy of preterm birthPre-pregnancy BMIQuantile-based g-computation approachIL-6Prenatal PFAS exposureInflammatory processPregnancy plasma samplesMeasurement of inflammatory biomarkersBirth outcomesLinear mixed modelsInverse associationRange increaseMaternal raceMaternal demographicsTNF-a levelsAdverse pregnancyAfrican AmericansPrenatal per- and polyfluoroalkyl substances (PFAS) and maternal oxidative stress: Evidence from the LIFECODES study
Siwakoti R, Park S, Ferguson K, Hao W, Cantonwine D, Mukherjee B, McElrath T, Meeker J. Prenatal per- and polyfluoroalkyl substances (PFAS) and maternal oxidative stress: Evidence from the LIFECODES study. Chemosphere 2024, 360: 142363. PMID: 38768789, PMCID: PMC11487489, DOI: 10.1016/j.chemosphere.2024.142363.Peer-Reviewed Original ResearchFetal sexMaternal raceEffect modificationOS biomarkersOxidative stressPre-pregnancy BMIAdverse pregnancy outcomesNo significant effect modificationMaternal oxidative stressPlasma PFASsSignificant effect modificationInterquartile range increasePositive associationExposure to OSPre-pregnancyPregnancy outcomesMaternal ageMultivariate linear regressionSex-specific effectsLinear mixed-effects modelsPotential confoundersInsurance statusRange increaseEndocrine functionEducation level