Investigating parent of origin effects (POE) and anticipation in Irish Lynch syndrome kindreds.
Farrell M, Hughes D, Schmid J, Boonstra P, Mukherjee B, Walshe M, Mac Mathuna P, Green A, Gallagher D. Investigating parent of origin effects (POE) and anticipation in Irish Lynch syndrome kindreds. Journal Of Clinical Oncology 2013, 31: 1542-1542. DOI: 10.1200/jco.2013.31.15_suppl.1542.Peer-Reviewed Original ResearchAffected parent-child pairsParent-of-origin effectsParent-child pairsLS familiesLynch syndromePaired t-testInvestigate parent-of-origin effectsCancer genetics centresLynch syndrome kindredHospital-based registryT-testOffspring of affected mothersRisk of diseaseGenetic centresEvidence of anticipationInvestigate parentGenetic anticipationDisease allelesAffected fatherStatistical significanceEarly onsetMothersSeverity of diseaseFamilyCancerElevated Risk of Prostate Cancer Among Men With Lynch Syndrome
Raymond V, Mukherjee B, Wang F, Huang S, Stoffel E, Kastrinos F, Syngal S, Cooney K, Gruber S. Elevated Risk of Prostate Cancer Among Men With Lynch Syndrome. Journal Of Clinical Oncology 2013, 31: 1713-1718. PMID: 23530095, PMCID: PMC3641694, DOI: 10.1200/jco.2012.44.1238.Peer-Reviewed Original ResearchConceptsLynch syndromeCumulative lifetime riskRisk of prostate cancerAge-specific cumulative riskLifetime risk of prostate cancerFamilial cancer registryGeneral populationHazard ratioCumulative risk of prostate cancerModified segregation analysisProstate cancerFourth-degree relativesCumulative riskProstate cancer riskLS familiesCancer RegistryCancer riskLifetime riskCases of prostate cancerPopulation riskMismatch repair-deficient phenotypeWald-type CICancer diagnosisMutation carriersElevated riskInvestigating parent of origin effects (POE) and anticipation in Irish Lynch syndrome kindreds.
Farrell M, Hughes D, Schmid J, Boonstra P, Mukherjee B, Walshe M, Mac Mathuna P, Gallagher D. Investigating parent of origin effects (POE) and anticipation in Irish Lynch syndrome kindreds. Journal Of Clinical Oncology 2013, 31: 431-431. DOI: 10.1200/jco.2013.31.4_suppl.431.Peer-Reviewed Original ResearchAffected parent-child pairsParent-of-origin effectsParent-child pairsInvestigate parent-of-origin effectsLynch syndrome familiesMMR mutation carriersLynch syndrome kindredGenetic anticipationHospital-based registryOffspring of affected mothersLS familiesLynch syndromePaired t-testRisk of diseaseSyndrome familiesMutation carriersInvestigate parentT-testDisease allelesAffected fatherStatistical significanceKindredMothersSeverity of diseaseFamily