2019
Manganese is associated with increased plasma interleukin-1β during pregnancy, within a mixtures analysis framework of urinary trace metals
Aung M, Meeker J, Boss J, Bakulski K, Mukherjee B, Cantonwine D, McElrath T, Ferguson K. Manganese is associated with increased plasma interleukin-1β during pregnancy, within a mixtures analysis framework of urinary trace metals. Reproductive Toxicology 2019, 93: 43-53. PMID: 31881266, PMCID: PMC7138746, DOI: 10.1016/j.reprotox.2019.12.004.Peer-Reviewed Original ResearchConceptsIL-1BBayesian kernel machine regressionKernel machine regressionInterleukin-1bInterquartile range differenceCross-sectional studyAssociated with biomarkersReproductive health outcomesImmune signaling moleculesHealth outcomesLIFECODES birth cohortPregnant womenImmune perturbationsImmune biomarkersBirth cohortUrinary manganeseMachine regressionLinear regressionExposure analytesAssociationSignaling moleculesRegressionPair-wise associationsTrimesterPregnancyPrediction and associations of preterm birth and its subtypes with eicosanoid enzymatic pathways and inflammatory markers
Aung M, Yu Y, Ferguson K, Cantonwine D, Zeng L, McElrath T, Pennathur S, Mukherjee B, Meeker J. Prediction and associations of preterm birth and its subtypes with eicosanoid enzymatic pathways and inflammatory markers. Scientific Reports 2019, 9: 17049. PMID: 31745121, PMCID: PMC6863859, DOI: 10.1038/s41598-019-53448-z.Peer-Reviewed Original ResearchConceptsSpontaneous preterm birthPreterm birthMultiple logistic regressionCross-sectional study of pregnant womenAssociation of preterm birthCases of preterm birthStudy of pregnant womenOverall preterm birthPreterm birth casesPreterm birth outcomesCytochrome P450 metabolitesLogistic regressionOxidative stress markersAberrant placentationCross-sectional studyDelivered termCytochrome P450 productPredictive biomarkersPregnant womenPretermEicosanoid metabolitesImmune biomarkersLipoxygenase metabolitesBirth casesResolvin D1
2018
The Relationships between Maternal Urinary Trace Metals and Plasma Immune Biomarkers during Pregnancy
Aung T, Meeker J, Boss J, Bakulski K, Mukherjee B, Cantonwine D, McElrath T, Ferguson K. The Relationships between Maternal Urinary Trace Metals and Plasma Immune Biomarkers during Pregnancy. ISEE Conference Abstracts 2018, 2018 DOI: 10.1289/isesisee.2018.o01.04.23.Peer-Reviewed Original Research
2016
Decreased Anti-Tumor Cytotoxic Immunity among Microsatellite-Stable Colon Cancers from African Americans
Basa R, Davies V, Li X, Murali B, Shah J, Yang B, Li S, Khan M, Tian M, Tejada R, Hassan A, Washington A, Mukherjee B, Carethers J, McGuire K. Decreased Anti-Tumor Cytotoxic Immunity among Microsatellite-Stable Colon Cancers from African Americans. PLOS ONE 2016, 11: e0156660. PMID: 27310868, PMCID: PMC4911070, DOI: 10.1371/journal.pone.0156660.Peer-Reviewed Original ResearchConceptsGranzyme B+ cellsColorectal cancerCytotoxic immunityB+ cellsAnti-tumor cytotoxic T lymphocytesColon cancerMicrosatellite-stable colon cancerCytotoxic T lymphocytesIL-17 expressionWilcoxon rank sum testProtection to patientsAfrican American colorectal cancerRank sum testTwo-sample Wilcoxon rank-sum testCD57+CD8+Invasive borderCytotoxic markersNo significant differenceT lymphocytesColon tumorsDescriptive summary statisticsImmune biomarkersTumor samplesImmune cytotoxicity