2023
Environmental risk scores of persistent organic pollutants associate with higher ALS risk and shorter survival in a new Michigan case/control cohort
Goutman S, Boss J, Jang D, Mukherjee B, Richardson R, Batterman S, Feldman E. Environmental risk scores of persistent organic pollutants associate with higher ALS risk and shorter survival in a new Michigan case/control cohort. Journal Of Neurology Neurosurgery & Psychiatry 2023, 95: 241-248. PMID: 37758454, PMCID: PMC11060633, DOI: 10.1136/jnnp-2023-332121.Peer-Reviewed Original ResearchConceptsEnvironmental risk scoreAmyotrophic lateral sclerosis riskPersistent organic pollutantsALS riskInterquartile increaseHigher ALS riskAssociated with ALS riskModify disease riskOrganochlorine pesticidesAssociated with riskRisk reduction strategiesPersistent organic pollutant analysisIndividual persistent organic pollutantsPersistent organic pollutant mixturesHazard ratioDisease riskRisk scoreCase/control cohortEnvironmental exposuresControl participantsGenetic susceptibilityPolychlorinated biphenylsAlpha-hexachlorocyclohexaneOrganic pollutantsMortality ratePhthalates and Incident Diabetes in Midlife Women: The Study of Women's Health Across the Nation (SWAN)
Peng M, Karvonen-Gutierrez C, Herman W, Mukherjee B, Park S. Phthalates and Incident Diabetes in Midlife Women: The Study of Women's Health Across the Nation (SWAN). The Journal Of Clinical Endocrinology & Metabolism 2023, 108: 1947-1957. PMID: 36752637, PMCID: PMC10348472, DOI: 10.1210/clinem/dgad033.Peer-Reviewed Original ResearchConceptsStudy of Women's HealthIncidence of diabetesWomen's HealthIncident diabetesMono-carboxyisononyl phthalatePhthalate metabolitesAssociated with diabetes incidenceHazard ratioCohort of midlife womenHealth-related factorsRacially/ethnically diverse cohortHigh-molecular-weight phthalate metabolitesTime-varying exposureCox proportional hazards modelsProportional hazards modelEffect modificationMono-isobutyl phthalateRacial/ethnic groupsDiabetes incidenceMono(3-carboxypropyl) phthalateMidlife womenMono-carboxyoctyl phthalateWhite womenAsian womenLongitudinal evidenceAssociations Between Repeated Measures of Urinary Phthalate Metabolites With Hormones and Timing of Natural Menopause
Ding N, Zheutlin E, Harlow S, Randolph J, Mukherjee B, Park S. Associations Between Repeated Measures of Urinary Phthalate Metabolites With Hormones and Timing of Natural Menopause. Journal Of The Endocrine Society 2023, 7: bvad024. PMID: 36846211, PMCID: PMC9945847, DOI: 10.1210/jendso/bvad024.Peer-Reviewed Original ResearchSex hormone-binding globulinFollicle-stimulating hormoneAnti-Mullerian hormoneUrinary phthalate metabolitesTiming of natural menopausePhthalate metabolitesNatural menopauseExposure to phthalatesMeasures of urinary phthalate metabolitesAssociations of phthalate metabolitesHazard ratioAssociations of urinary phthalate metabolitesSerum concentrations of estradiolHormone-binding globulinCox proportional-hazards modelStudy of Women's HealthConcentrations of estradiolCalculate hazard ratiosProportional-hazards modelStatistically significant associationCirculating levels of testosteroneLevels of testosteroneHormone therapyOvarian reserveMidlife women
2022
Per- and Polyfluoroalkyl Substances and Incident Hypertension in Multi-Racial/Ethnic Women: The Study of Women's Health Across the Nation
Ding N, Karvonen-Gutierrez C, Mukherjee B, Calafat A, Harlow S, Park S. Per- and Polyfluoroalkyl Substances and Incident Hypertension in Multi-Racial/Ethnic Women: The Study of Women's Health Across the Nation. Hypertension 2022, 79: 1876-1886. PMID: 35695012, PMCID: PMC9308661, DOI: 10.1161/hypertensionaha.121.18809.Peer-Reviewed Original ResearchConceptsHazard ratioIncident hypertensionLowest tertileHighest tertileStudy of Women's HealthFree of hypertensionCalculate hazard ratiosAnnual follow-up visitsCardiovascular disease riskCox proportional hazards modelsQuantile g-computationWomen's cardiovascular disease riskWomen's HealthNo significant associationProportional hazards modelMidlife womenFollow-up visitG-computationDisease riskBlood pressure controlSerum concentrationsSignificant associationPositive associationHazards modelTertileMetals and risk of incident metabolic syndrome in a prospective cohort of midlife women in the United States
Wang X, Karvonen-Gutierrez C, Herman W, Mukherjee B, Park S. Metals and risk of incident metabolic syndrome in a prospective cohort of midlife women in the United States. Environmental Research 2022, 210: 112976. PMID: 35202625, PMCID: PMC9869389, DOI: 10.1016/j.envres.2022.112976.Peer-Reviewed Original ResearchConceptsEnvironmental risk scoreCohort of midlife womenIncident MetSMidlife womenHazard ratioRisk of incident MetSRisk of incident metabolic syndromeProspective cohortStudy of Women's HealthFree of MetSRisk of cardiometabolic diseasesIncident metabolic syndromeMetabolic syndromeImpaired fasting glucoseCox proportional hazards modelsHigh-density lipoprotein cholesterolHigh blood pressureMetS incidenceWomen's HealthProportional hazards modelAbdominal obesityNation Multi-Pollutant StudyDevelopment of metabolic syndromeCardiometabolic diseasesHigh triglycerides
2021
Urinary concentrations of phenols and parabens and incident diabetes in midlife women
Lee S, Karvonen-Gutierrez C, Mukherjee B, Herman W, Harlow S, Park S. Urinary concentrations of phenols and parabens and incident diabetes in midlife women. Environmental Epidemiology 2021, 5: e171. PMID: 34934892, PMCID: PMC8683147, DOI: 10.1097/ee9.0000000000000171.Peer-Reviewed Original ResearchIncident diabetesHazard ratioAssociated with incident diabetesStudy of Women's HealthMid-life womenAdjusted hazard ratiosAssociation of incident diabetesProspective cohort studyWomen's HealthNo significant associationWomen's backgroundConcentration of phenolJoint effectsExposure variablesG-computationQuantile-based g-computationWithin-person variabilityBenzophenone-3Cohort studyDiabetes-freeBisphenol ANonlinear associationSignificant associationJoint effect of mixturesConcentrations of bisphenol AUrinary metals and metal mixtures and timing of natural menopause in midlife women: The Study of Women’s Health Across the Nation
Wang X, Ding N, Harlow S, Randolph J, Mukherjee B, Gold E, Park S. Urinary metals and metal mixtures and timing of natural menopause in midlife women: The Study of Women’s Health Across the Nation. Environment International 2021, 157: 106781. PMID: 34311223, PMCID: PMC8490279, DOI: 10.1016/j.envint.2021.106781.Peer-Reviewed Original ResearchConceptsMetal mixturesMetal concentrationsTiming of natural menopauseCox proportional hazards modelsNatural menopauseStudy of Women's HealthProportional hazards modelHazard ratioEnvironmental risk scoreLowest quartileIndividual metal concentrationsExposure to metalsUrinary metal concentrationsHazards modelMedian follow-upMonths of amenorrheaWomen's HealthAssociated with earlier natural menopauseEarly natural menopauseUrinary metalsNation Multi-Pollutant StudyBleeding episodesHormone therapyPremenopausal womenMedian age
2020
Associations of Perfluoroalkyl Substances with Incident Natural Menopause: The Study of Women’s Health Across the Nation
Ding N, Harlow S, Randolph J, Calafat A, Mukherjee B, Batterman S, Gold E, Park S. Associations of Perfluoroalkyl Substances with Incident Natural Menopause: The Study of Women’s Health Across the Nation. The Journal Of Clinical Endocrinology & Metabolism 2020, 105: dgaa303. PMID: 32491182, PMCID: PMC7418447, DOI: 10.1210/clinem/dgaa303.Peer-Reviewed Original ResearchConceptsStudy of Women's HealthNatural menopauseHazard ratioSerum concentrationsWomen's HealthCohort of midlife womenConfidence intervalsCalculate hazard ratiosAdverse health outcomesPFAS serum concentrationsMonths of amenorrheaAssociation of perfluoroalkyl substancesEarly natural menopauseBaseline serum concentrationsCox proportional hazards modelsAssociated with earlier natural menopauseIsotope dilution tandem mass spectrometryHealth outcomesProportional hazards modelReverse causationBleeding episodesMidlife womenLowest tertileMedian timeHormone use
2018
Bone Lead Levels and Risk of Incident Primary Open-Angle Glaucoma: The VA Normative Aging Study
Wang W, Moroi S, Bakulski K, Mukherjee B, Weisskopf M, Schaumberg D, Sparrow D, Vokonas P, Hu H, Park S. Bone Lead Levels and Risk of Incident Primary Open-Angle Glaucoma: The VA Normative Aging Study. Environmental Health Perspectives 2018, 126: 087002. PMID: 30102601, PMCID: PMC6108844, DOI: 10.1289/ehp3442.Peer-Reviewed Original ResearchConceptsPrimary open-angle glaucomaIncident primary open-angle glaucomaRisk of primary open-angle glaucomaOpen-angle glaucomaHazard ratioIncident cases of POAGCases of primary open-angle glaucomaAsymmetric cup-to-disc ratioFollow-upPrimary open-angle glaucoma casesEtiology of primary open-angle glaucomaCup-to-disc ratioVisual field defectsCox proportional hazards regressionAssociated with hazard ratiosProportional hazards regressionOxidative stressEstimate hazard ratiosDisc hemorrhageOcular evaluationPatella leadField defectsCumulative lead doseProspective cohortSurvival curvesAssociations between mixtures of urinary phthalate metabolites with gestational age at delivery: a time to event analysis using summative phthalate risk scores
Boss J, Zhai J, Aung M, Ferguson K, Johns L, McElrath T, Meeker J, Mukherjee B. Associations between mixtures of urinary phthalate metabolites with gestational age at delivery: a time to event analysis using summative phthalate risk scores. Environmental Health 2018, 17: 56. PMID: 29925380, PMCID: PMC6011420, DOI: 10.1186/s12940-018-0400-3.Peer-Reviewed Original ResearchConceptsMono-2-ethyl-5-carboxypentyl phthalateEnvironmental risk scoreGestational ageHazard ratioPreterm birthRisk scoreInterquartile rangeIncreased odds of preterm birthCases of preterm birthOdds of preterm birthUrinary phthalate metabolite concentrationsPhthalate metabolite concentrationsUrinary phthalate metabolitesPhthalate metabolite measurementsCox proportional hazards modelsInterquartile range changeTime to deliveryProportional hazards modelLongitudinal birth cohortSingle-pollutant analysesSignificant public health concernUrinary metabolite concentrationsBackgroundPreterm birthPregnant womenExposure to phthalates
2016
Repeated measures of inflammation and oxidative stress biomarkers in preeclamptic and normotensive pregnancies
Ferguson K, Meeker J, McElrath T, Mukherjee B, Cantonwine D. Repeated measures of inflammation and oxidative stress biomarkers in preeclamptic and normotensive pregnancies. American Journal Of Obstetrics And Gynecology 2016, 216: 527.e1-527.e9. PMID: 28043842, PMCID: PMC5420472, DOI: 10.1016/j.ajog.2016.12.174.Peer-Reviewed Original ResearchConceptsTumor necrosis factor-aNormotensive pregnanciesC-reactive proteinMeasures of inflammationHazard ratioOxidative stress biomarkersInterleukin-1bTime pointsInflammation biomarkersStudy visitsTime of preeclampsia diagnosisPrediction of preeclampsiaOxidative stressHigher body mass indexOxidative stress biomarker 8-isoprostaneStress biomarkersCox proportional hazards modelsCompared to other time pointsBody mass indexProspective birth cohortCalculate hazard ratiosSmall study populationPanel of inflammationFactor AProportional hazards modelUrinary Concentrations of Bisphenol A and Phthalate Metabolites Measured during Pregnancy and Risk of Preeclampsia
Cantonwine D, Meeker J, Ferguson K, Mukherjee B, Hauser R, McElrath T. Urinary Concentrations of Bisphenol A and Phthalate Metabolites Measured during Pregnancy and Risk of Preeclampsia. Environmental Health Perspectives 2016, 124: 1651-1655. PMID: 27177253, PMCID: PMC5047771, DOI: 10.1289/ehp188.Peer-Reviewed Original ResearchRisk of preeclampsiaUrinary concentrations of BPAUrinary concentrations of bisphenol APhthalate metabolitesUrinary concentrationsAssociated with increased risk of preeclampsiaHazard ratioCases of preeclampsiaNested case-control studyDevelopment of preeclampsiaProspective birth cohort studyAssociated with increased riskPhthalate metabolite concentrationsCox proportional hazards modelsAdjusted Cox proportional hazards modelsCase-control studyAdjusted hazard ratiosCalculate hazard ratiosProportional hazards modelBirth cohort studyWeeks gestationPreterm birthAssociated with onsetPreeclampsiaUrinary BPA
2013
Elevated Risk of Prostate Cancer Among Men With Lynch Syndrome
Raymond V, Mukherjee B, Wang F, Huang S, Stoffel E, Kastrinos F, Syngal S, Cooney K, Gruber S. Elevated Risk of Prostate Cancer Among Men With Lynch Syndrome. Journal Of Clinical Oncology 2013, 31: 1713-1718. PMID: 23530095, PMCID: PMC3641694, DOI: 10.1200/jco.2012.44.1238.Peer-Reviewed Original ResearchConceptsLynch syndromeCumulative lifetime riskRisk of prostate cancerAge-specific cumulative riskLifetime risk of prostate cancerFamilial cancer registryGeneral populationHazard ratioCumulative risk of prostate cancerModified segregation analysisProstate cancerFourth-degree relativesCumulative riskProstate cancer riskLS familiesCancer RegistryCancer riskLifetime riskCases of prostate cancerPopulation riskMismatch repair-deficient phenotypeWald-type CICancer diagnosisMutation carriersElevated risk
2011
High Risk of Colorectal and Endometrial Cancer in Ashkenazi Families With the MSH2 A636P Founder Mutation
Mukherjee B, Rennert G, Ahn J, Dishon S, Lejbkowicz F, Rennert H, Shiovitz S, Moreno V, Gruber S. High Risk of Colorectal and Endometrial Cancer in Ashkenazi Families With the MSH2 A636P Founder Mutation. Gastroenterology 2011, 140: 1919-1926. PMID: 21419771, PMCID: PMC4835182, DOI: 10.1053/j.gastro.2011.02.071.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAgedAged, 80 and overCase-Control StudiesColorectal Neoplasms, Hereditary NonpolyposisEndometrial NeoplasmsFemaleFounder EffectGene FrequencyGenetic Predisposition to DiseaseGenetic TestingHeredityHumansIsraelJewsLikelihood FunctionsMaleMass ScreeningMiddle AgedMutationMutS Homolog 2 ProteinPedigreePenetrancePhenotypeProportional Hazards ModelsRegistriesRisk AssessmentRisk FactorsSex FactorsYoung AdultConceptsRisk of colorectal cancerHazard ratioColorectal cancerCumulative riskPopulation-basedLifetime risk of colorectal cancerCumulative risk of colorectal cancerEstimates of colorectal cancerAge-specific cumulative riskHigh risk of colorectalCases of colorectal cancerModified segregation analysisRisk of colorectalClinical genetics servicesClinic-based sampleEndometrial cancerRisk of ECCase-control studyGenetic servicesLynch syndromeCancer screeningEC riskLifetime riskAshkenazi familiesEstimated penetrance
2009
Calculation of Risk of Colorectal and Endometrial Cancer Among Patients With Lynch Syndrome
Stoffel E, Mukherjee B, Raymond V, Tayob N, Kastrinos F, Sparr J, Wang F, Bandipalliam P, Syngal S, Gruber S. Calculation of Risk of Colorectal and Endometrial Cancer Among Patients With Lynch Syndrome. Gastroenterology 2009, 137: 1621-1627. PMID: 19622357, PMCID: PMC2767441, DOI: 10.1053/j.gastro.2009.07.039.Peer-Reviewed Original ResearchConceptsRisk of colorectal cancerCumulative risk of colorectal cancerHazard ratioColorectal cancerCumulative riskLifetime risk of colorectal cancerMismatch repair gene mutation carriersEstimates of colorectal cancerAge-specific cumulative riskMismatch repair gene mutationsEstimates of lifetime riskCancer genetics clinicsCases of colorectal cancerModified segregation analysisRisk of colorectalColorectal cancer riskHereditary colorectal cancerEndometrial cancerGene mutation carriersRepair gene mutationsRisk of ECOverestimation of penetrationFirst-degree relativesLynch syndromeCancer surveillance