2014
No effect of acute exposure to coarse particulate matter air pollution in a rural location on high-density lipoprotein function
Maiseyeu A, Yang H, Ramanathan G, Yin F, Bard R, Morishita M, Dvonch J, Wang L, Spino C, Mukherjee B, Badgeley M, Barajas-Espinosa A, Sun Q, Harkema J, Rajagopalan S, Araujo J, Brook R. No effect of acute exposure to coarse particulate matter air pollution in a rural location on high-density lipoprotein function. Inhalation Toxicology 2014, 26: 23-29. PMID: 24417404, PMCID: PMC4445365, DOI: 10.3109/08958378.2013.850761.Peer-Reviewed Original ResearchConceptsRural locationsParticulate matter air pollutionHDL dysfunctionHDL anti-oxidative capacityRandomized double-blind crossover studyDouble-blind crossover studyHDL functionHDL-mediated cholesterol efflux capacityParaoxonase activityFiltered airVascular protective functionCholesterol efflux capacityHigh-density lipoprotein (HDL) particlesMetrics of HDL functionHDL-mediated effluxConcentrated ambient particlesCrossover studyImpact of PMEfflux capacityPM exposureVenous bloodAnimal studiesHealthy humansCoarse PMWilcoxon test
2013
The effect of acute exposure to coarse particulate matter air pollution in a rural location on circulating endothelial progenitor cells: results from a randomized controlled study
Brook R, Bard R, Kaplan M, Yalavarthi S, Morishita M, Dvonch J, Wang L, Yang H, Spino C, Mukherjee B, Oral E, Sun Q, Brook J, Harkema J, Rajagopalan S. The effect of acute exposure to coarse particulate matter air pollution in a rural location on circulating endothelial progenitor cells: results from a randomized controlled study. Inhalation Toxicology 2013, 25: 587-592. PMID: 23919441, PMCID: PMC4364610, DOI: 10.3109/08958378.2013.814733.Peer-Reviewed Original ResearchConceptsCirculating endothelial progenitor cellsRural locationsVascular endothelial growth factorEndothelial progenitor cellsCirculating EPC levelsCoarse PMWhite blood cellsParticulate matterConcentrated ambient particlesParticulate matter air pollutionAir pollutionFine particulate matterEPC levelsProgenitor cellsWilcoxon signed-rank testRandomized double-blind crossover studyDouble-blind crossover studyFiltered airSigned-rank testBlood cellsPeripheral venous bloodSympathetic nervous system activityEndothelial growth factorAssociated with alterationsCardiovascular disease
2011
PM2.5-induced changes in cardiac function of hypertensive rats depend on wind direction and specific sources in Steubenville, Ohio
Kamal A, Rohr A, Mukherjee B, Morishita M, Keeler G, Harkema J, Wagner J. PM2.5-induced changes in cardiac function of hypertensive rats depend on wind direction and specific sources in Steubenville, Ohio. Inhalation Toxicology 2011, 23: 417-430. PMID: 21639710, DOI: 10.3109/08958378.2011.580387.Peer-Reviewed Original ResearchConceptsNE windsSW windsSource factorsMobile source factorsPositive matrix factorizationConcentrated ambient particlesPotential emission sourcesSources of PM(2.5Adverse health effectsPM constituentsWind directionParticulate matterMobile sourcesIndividual elemental componentsTrace elementsAmbient particlesIron/steel productionPM(2.5IncinerationAmbient PM(2.5Metal factorWindHealth effectsExposure to concentrated ambient particlesSouthwest