Pharmacological effects of methylone and MDMA in humans
Poyatos L, Pérez-Mañá C, Hladun O, Núñez-Montero M, de la Rosa G, Martín S, Barriocanal A, Carabias L, Kelmendi B, Taoussi O, Busardò F, Fonseca F, Torrens M, Pichini S, Farré M, Papaseit E. Pharmacological effects of methylone and MDMA in humans. Frontiers In Pharmacology 2023, 14: 1122861. PMID: 36873994, PMCID: PMC9981643, DOI: 10.3389/fphar.2023.1122861.Peer-Reviewed Original ResearchAddiction Research Center InventoryVisual analog scaleSubjective effectsClinical trialsPharmacological effectsAbuse potentialAcute pharmacological effectsCrossover clinical trialSingle oral doseMechanism of actionBlood pressureEffect profileOral doseAnalog scaleOral administrationHeart ratePrevious historyPsychostimulant usePsychomotor performanceOverall onsetPleasurable effectsMDMAPhysiological effectsShort formEarly disappearancePilot study suggests DNA methylation of the glucocorticoid receptor gene (NR3C1) is associated with MDMA-assisted therapy treatment response for severe PTSD
Lewis C, Tafur J, Spencer S, Green J, Harrison C, Kelmendi B, Rabin D, Yehuda R, Yazar-Klosinski B, Cahn B. Pilot study suggests DNA methylation of the glucocorticoid receptor gene (NR3C1) is associated with MDMA-assisted therapy treatment response for severe PTSD. Frontiers In Psychiatry 2023, 14: 959590. PMID: 36815187, PMCID: PMC9939628, DOI: 10.3389/fpsyt.2023.959590.Peer-Reviewed Original ResearchPost-traumatic stress disorderSevere post-traumatic stress disorderTreatment responseClinical trialsRecent phase 3 clinical trialsPhase 3 clinical trialsClinician-Administered PTSD ScaleParent clinical trialKey HPA axis genesHPA axis genesPTSD symptom improvementGlucocorticoid receptor geneFalse discovery rate correctionAdrenal genesPlacebo groupSymptom improvementLarge cohortMethylation changesEpigenetic changesSymptom reductionPTSD ScaleTherapyHPA genesStress disorderPilot study