2017
A Systematic Review of Proinsulin-Secreting Pancreatic Neuroendocrine Tumors
Murtha TD, Lupsa BC, Majumdar S, Jain D, Salem RR. A Systematic Review of Proinsulin-Secreting Pancreatic Neuroendocrine Tumors. Journal Of Gastrointestinal Surgery 2017, 21: 1335-1341. PMID: 28510792, DOI: 10.1007/s11605-017-3428-8.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsPancreatic neuroendocrine tumorsNeuroendocrine tumorsSystematic reviewRare pancreatic neuroendocrine tumorYale-New Haven HospitalMajority of patientsMedian tumor diameterLower insulin levelsBiomedical databases PubMedNew Haven HospitalSymptomatic hypoglycemiaMost patientsFemale predominanceTumor diameterClinicopathologic featuresInsulin levelsUncommon diseaseMean ageOvid MEDLINEHormonal levelsDatabases PubMedPatientsProinsulinomaHormone productionTumors
2010
Cardiomyopathy in Congenital and Acquired Generalized Lipodystrophy
Lupsa BC, Sachdev V, Lungu AO, Rosing DR, Gorden P. Cardiomyopathy in Congenital and Acquired Generalized Lipodystrophy. Medicine 2010, 89: 245-250. PMID: 20616664, PMCID: PMC3090142, DOI: 10.1097/md.0b013e3181e9442f.Peer-Reviewed Original ResearchConceptsCohort of patientsGeneralized lipodystrophyCardiac findingsInsulin resistanceHypertrophic cardiomyopathyAcquired Generalized LipodystrophyLower leptin levelsExtreme insulin resistanceDiabetes mellitusLeptin therapyLeptin levelsSevere dyslipidemiaCardiac statusFrequent findingClinical trialsRare disorderPatientsAdipose tissueCardiomyopathyLipodystrophyCongenitalSeipin mutationsUnderlying mechanismPhenotypic featuresCohort
2009
Efficacy of leptin therapy in the different forms of human lipodystrophy
Chong AY, Lupsa BC, Cochran EK, Gorden P. Efficacy of leptin therapy in the different forms of human lipodystrophy. Diabetologia 2009, 53: 27. PMID: 19727665, DOI: 10.1007/s00125-009-1502-9.Peer-Reviewed Original ResearchConceptsForms of lipodystrophyLipodystrophy patientsLeptin therapyLeptin replacementSerum triacylglycerolOpen-label prospective studySevere insulin resistanceNational InstituteGlycaemic controlHDL cholesterolLDL cholesterolTotal cholesterolMetabolic abnormalitiesKidney diseaseProspective studyInsulin resistanceRare disorderSustained improvementPatientsAdipose tissueLipodystrophyHuman lipodystrophyPPARγ geneTherapyDyslipidaemiaAutoimmune Forms of Hypoglycemia
Lupsa BC, Chong AY, Cochran EK, Soos MA, Semple RK, Gorden P. Autoimmune Forms of Hypoglycemia. Medicine 2009, 88: 141-153. PMID: 19440117, DOI: 10.1097/md.0b013e3181a5b42e.Peer-Reviewed Original ResearchConceptsInsulin autoimmune syndromeType B insulin resistanceAnti-insulin receptor antibodiesAutoimmune syndromeAutoimmune formInsulin resistanceReceptor antibodiesPancreatic surgical proceduresCause of hypoglycemiaNon-Asian patientsAnti-insulin antibodiesNon-Asian populationsLaboratory featuresClinical courseWhite patientsHypoglycemic patientsRare causeInsulin levelsHyperinsulinemic hypoglycemiaSurgical proceduresCorrect diagnosisHypoglycemiaPatientsSyndromeElevated levels