Featured Publications
Impact of Cardiovascular Risk on the Relative Benefit and Harm of Intensive Treatment of Hypertension
Phillips RA, Xu J, Peterson LE, Arnold RM, Diamond JA, Schussheim AE. Impact of Cardiovascular Risk on the Relative Benefit and Harm of Intensive Treatment of Hypertension. Journal Of The American College Of Cardiology 2018, 71: 1601-1610. PMID: 29525494, DOI: 10.1016/j.jacc.2018.01.074.Peer-Reviewed Original ResearchMeSH KeywordsAgedAntihypertensive AgentsFemaleHumansHypertensionMaleProportional Hazards ModelsRisk AssessmentUnited StatesConceptsSignificant serious adverse eventsPrimary outcome eventIntensive treatment groupCVD riskOutcome eventsHarm ratioIntensive treatmentTreatment groupsTreatment guidelinesAmerican CollegeCardiology/American Heart AssociationFuture cardiovascular disease riskCox proportional hazards modelBaseline CVD riskQuartiles of baselineSerious adverse eventsBlood pressure treatmentCardiovascular disease riskAmerican Heart AssociationProportional hazards modelLower ratesSPRINT populationAdverse eventsCardiovascular riskPrimary outcome
2001
Left ventricular midwall function improves with antihypertensive therapy and regression of left ventricular hypertrophy in patients with asymptomatic hypertension
Schussheim A, Diamond J, Phillips R. Left ventricular midwall function improves with antihypertensive therapy and regression of left ventricular hypertrophy in patients with asymptomatic hypertension. The American Journal Of Cardiology 2001, 87: 61-65. PMID: 11137835, DOI: 10.1016/s0002-9149(00)01273-x.Peer-Reviewed Original ResearchConceptsMidwall fractional shorteningLV mass regressionAntihypertensive therapyAsymptomatic hypertensionVentricular hypertrophyMidwall functionMass regressionEarly hypertensive heart diseaseConventional echocardiographic parametersHypertensive heart diseaseLeft ventricular massPotential beneficial effectsEchocardiographic parametersFractional shorteningHypertensive personsIndependent predictorsVentricular massDrug therapyMyocardial performanceHeart diseaseCardiac performanceVentricular geometryChamber functionPatientsTherapy
1998
Midwall fractional shortening is an independent predictor of left ventricular diastolic dysfunction in asymptomatic patients with systemic hypertension
Schussheim A, Diamond J, Jhang J, Phillips R. Midwall fractional shortening is an independent predictor of left ventricular diastolic dysfunction in asymptomatic patients with systemic hypertension. The American Journal Of Cardiology 1998, 82: 1056-1059. PMID: 9817481, DOI: 10.1016/s0002-9149(98)00558-x.Peer-Reviewed Original ResearchConceptsMidwall fractional shorteningAbnormal diastolic functionMidwall shorteningHypertensive patientsSystolic functionDiastolic functionFractional shorteningDiastolic dysfunctionBlood pressureIndependent predictorsSystolic performanceEndocardial shorteningFiber shorteningLeft ventricular systolic performanceDepressed midwall shorteningHealthy hypertensive patientsLV diastolic abnormalitiesLV inflow velocityNormal midwall shorteningTarget organ damageVentricular diastolic dysfunctionIsovolumic relaxation timeLV systolic functionHigh blood pressureVentricular systolic performance
1997
Usefulness of Subnormal Midwall Fractional Shortening in Predicting Left Ventricular Exercise Dysfunction in Asymptomatic Patients With Systemic Hypertension
Schussheim A, Devereux R, de Simone G, Borer J, Herrold E, Laragh J. Usefulness of Subnormal Midwall Fractional Shortening in Predicting Left Ventricular Exercise Dysfunction in Asymptomatic Patients With Systemic Hypertension. The American Journal Of Cardiology 1997, 79: 1070-1074. PMID: 9114766, DOI: 10.1016/s0002-9149(97)00049-0.Peer-Reviewed Original ResearchConceptsMidwall fractional shorteningAsymptomatic hypertensive patientsLV ejection fractionFractional shorteningBlood pressureHypertensive patientsEjection fractionHigher mean diastolic blood pressureExtracardiac target organ damageHigher urinary protein excretionLower midwall fractional shorteningMean diastolic blood pressureLV functional reserveSerum creatinine levelsTarget organ damageUrinary protein excretionDiastolic blood pressureSystolic blood pressureHigher LV massBody mass indexIdentification of patientsExercise dysfunctionAsymptomatic patientsSystemic hypertensionCreatinine levels
1995
Altered Na+-H+-exchange activity in the spontaneously hypertensive perfused rat heart
Schussheim A, Radda G. Altered Na+-H+-exchange activity in the spontaneously hypertensive perfused rat heart. Journal Of Molecular And Cellular Cardiology 1995, 27: 1475-1481. PMID: 8523411, DOI: 10.1016/s0022-2828(95)90128-0.Peer-Reviewed Original ResearchConceptsRat heartWistar-Kyoto controlsHypertensive rat heartsSHR groupSHR heartsFunctional recoveryDeveloped pressureHypercapnic acidosisControl groupPerfusion techniqueAcidosisSignificant differencesHeartExchange activitySpecific inhibitorMagnetic resonance spectroscopyGroupEarly periodHypertensionMajor role