2010
NMDA Receptors Activated by Subventricular Zone Astrocytic Glutamate Are Critical for Neuroblast Survival Prior to Entering a Synaptic Network
Platel JC, Dave KA, Gordon V, Lacar B, Rubio ME, Bordey A. NMDA Receptors Activated by Subventricular Zone Astrocytic Glutamate Are Critical for Neuroblast Survival Prior to Entering a Synaptic Network. Neuron 2010, 65: 859-872. PMID: 20346761, PMCID: PMC2861893, DOI: 10.1016/j.neuron.2010.03.009.Peer-Reviewed Original ResearchConceptsAdult-born neuronsNMDA receptorsNMDAR activitySynaptic networksNeuroblast survivalGlutamate release machineryAstrocyte-like cellsLoss of neuroblastsNeonatal electroporationSpecialized astrocytesAstrocytic glutamateOlfactory bulbVesicular releaseRelease machineryReceptorsNeuroblastsNeuronsIntercellular mechanismsSurvivalGlutamateNeuroblast apoptosisAstrocytesNeurogenesisNeurotransmittersSVZGABAA Increases Calcium in Subventricular Zone Astrocyte-Like Cells Through L- and T-Type Voltage-Gated Calcium Channels
Young SZ, Platel JC, Nielsen JV, Jensen NA, Bordey A. GABAA Increases Calcium in Subventricular Zone Astrocyte-Like Cells Through L- and T-Type Voltage-Gated Calcium Channels. Frontiers In Cellular Neuroscience 2010, 4: 8. PMID: 20422045, PMCID: PMC2857959, DOI: 10.3389/fncel.2010.00008.Peer-Reviewed Original ResearchVoltage-gated calcium channelsT-type voltage-gated calcium channelsAstrocyte-like cellsSubventricular zoneReceptor activationCalcium channelsFunctional voltage-gated calcium channelsChannel activator BayK 8644Glial fibrillary acidic protein promoterHuman glial fibrillary acidic protein promoterNeurogenic subventricular zonePostnatal subventricular zoneAcidic protein promoterAmbient GABABayK 8644Transgenic miceReceptor activityL-typeProtein promoterReceptorsTonicActivationCellsIntracellularMibefradil
2009
GABA increases Ca2+ in cerebellar granule cell precursors via depolarization: Implications for proliferation
Dave KA, Bordey A. GABA increases Ca2+ in cerebellar granule cell precursors via depolarization: Implications for proliferation. IUBMB Life 2009, 61: 496-503. PMID: 19391160, PMCID: PMC2675662, DOI: 10.1002/iub.185.Peer-Reviewed Original ResearchConceptsGamma-aminobutyric acidRole of GABAVertebrate central nervous systemComplement of receptorsCerebellar granule cell precursorsCell precursorsGranule cell precursorsDevelopmental processesMetabotropic glutamate receptorsCentral nervous systemCell proliferationAdult mammalsNovel targetAmino acid glutamatePharmacological regulationCurrent knowledgeGlutamate receptorsNeural cancersNervous systemCerebellar tumorsCalcium increaseReceptorsProliferationMammalsNovel dataEpendymal cells along the lateral ventricle express functional P2X7 receptors
Genzen JR, Platel JC, Rubio ME, Bordey A. Ependymal cells along the lateral ventricle express functional P2X7 receptors. Purinergic Signalling 2009, 5: 299-307. PMID: 19274488, PMCID: PMC2717311, DOI: 10.1007/s11302-009-9143-5.Peer-Reviewed Original ResearchP2X7 receptorEpendymal cellsSubventricular zoneWhole-cell patch-clamp recordingsCentral nervous system injuryFunctional P2X7 receptorsFunctional purinergic receptorsNervous system injuryPatch-clamp recordingsMouse subventricular zoneSVZ neurogenic nicheNeural progenitor responseAbsence of responseSystem injuryCerebral ventricleProgenitor responseLateral ventricleNeurogenic nichePurinergic receptorsClamp recordingsExtracellular adenosineReceptorsCellular damageWidespread expressionInflammation
2008
GABAA receptors, anesthetics and anticonvulsants in brain development.
Henschel O, Gipson KE, Bordey A. GABAA receptors, anesthetics and anticonvulsants in brain development. CNS & Neurological Disorders - Drug Targets 2008, 7: 211-24. PMID: 18537647, PMCID: PMC2557552, DOI: 10.2174/187152708784083812.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsGABAergic drugsBrain developmentLong-term cognitive deficitsMain inhibitory neurotransmitterFunction of GABANeonatal periodInhibitory neurotransmitterGABAA receptorsMature brainNeuronal excitabilitySide effectsCognitive deficitsClinical perspectiveGABACNS developmentReceptorsReceptor propertiesDrugsAnticonvulsantsAnestheticsBasic scienceReviewSedativesExcitabilityNeurotransmitters
2007
GABA and glutamate signaling: homeostatic control of adult forebrain neurogenesis
Platel JC, Lacar B, Bordey A. GABA and glutamate signaling: homeostatic control of adult forebrain neurogenesis. Journal Of Molecular Histology 2007, 38: 303-311. PMID: 17554632, PMCID: PMC2556597, DOI: 10.1007/s10735-007-9103-8.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsSubventricular zoneOlfactory bulb interneuronsGABAergic signalingGlutamate receptorsBulb interneuronsForebrain neurogenesisAMPA/kainate receptorsMetabotropic glutamate receptorsNeurogenic subventricular zoneRole of glutamateHomeostatic controlIonotropic glutamate receptorsEmbryonic cortical developmentSVZ neuroblastsNeurotransmitter GABASVZ cellsCortical developmentKainate receptorsGABA transporter subtypesNeurotransmitter glutamateGABA clearanceGABATransporter subtypesReceptorsInterneurons
2005
Nonsynaptic GABA signaling in postnatal subventricular zone controls proliferation of GFAP-expressing progenitors
Liu X, Wang Q, Haydar TF, Bordey A. Nonsynaptic GABA signaling in postnatal subventricular zone controls proliferation of GFAP-expressing progenitors. Nature Neuroscience 2005, 8: 1179-1187. PMID: 16116450, PMCID: PMC1380263, DOI: 10.1038/nn1522.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornBotulinum ToxinsBromodeoxyuridineCadmiumCell CountCell ProliferationChelating AgentsCyclooxygenase InhibitorsDose-Response Relationship, DrugDose-Response Relationship, RadiationDrug InteractionsEgtazic AcidElectric StimulationEnzyme InhibitorsGABA AntagonistsGamma-Aminobutyric AcidGene Expression RegulationGlial Fibrillary Acidic ProteinGreen Fluorescent ProteinsImmunohistochemistryIn Vitro TechniquesLateral VentriclesMeclofenamic AcidMembrane PotentialsMiceMice, TransgenicNeuronsNickelPatch-Clamp TechniquesPotassiumSodium Channel BlockersSpider VenomsStem CellsTetrodotoxinConceptsPostnatal subventricular zoneGFAP-expressing cellsSubventricular zoneCell cycleGABAA receptorsStem cellsNeuroblastsProgenitorsGlial fibrillary acidic proteinSVZ cellsGABAA receptor currentsGABAA receptor activationFibrillary acidic proteinReceptor activationCellsProliferationGABA releaseMouse slicesLocal cuesAcidic proteinReceptor currentsSpontaneous depolarizationsGFAPGABAReceptors
1996
Patch‐clamp characterization of nicotinic receptors in a subpopulation of lamina X neurones in rat spinal cord slices.
Bordey A, Feltz P, Trouslard J. Patch‐clamp characterization of nicotinic receptors in a subpopulation of lamina X neurones in rat spinal cord slices. The Journal Of Physiology 1996, 490: 673-678. PMID: 8683466, PMCID: PMC1158705, DOI: 10.1113/jphysiol.1996.sp021176.Peer-Reviewed Original ResearchConceptsLamina X neuronesSpinal cord slicesNicotinic acetylcholine receptorsCord slicesD-tubocurarineCentral canalTransverse thoracolumbar spinal cord slicesAcetylcholine receptorsAction potentialsRat spinal cord slicesWhole-cell patch-clamp techniqueDirect postsynaptic effectPatch-clamp techniqueStrong inward rectificationPostsynaptic effectsDorsal commissureNicotinic receptorsNicotinic agonistsPatch-clamp characterizationNeuronesVentral halfReceptors resultsReversal potentialReceptorsInward rectification