Featured Publications
Motivations of women in Uganda living with rheumatic heart disease: A mixed methods study of experiences in stigma, childbearing, anticoagulation, and contraception
Chang A, Nabbaale J, Nalubwama H, Okello E, Ssinabulya I, Longenecker C, Webel A. Motivations of women in Uganda living with rheumatic heart disease: A mixed methods study of experiences in stigma, childbearing, anticoagulation, and contraception. PLOS ONE 2018, 13: e0194030. PMID: 29590159, PMCID: PMC5874006, DOI: 10.1371/journal.pone.0194030.Peer-Reviewed Original ResearchConceptsWomen of childbearing ageRheumatic heart diseaseFocus groupsLack of health system resourcesLimited health literacyQualitative descriptive methodologyHealth system resourcesHeart diseaseMixed methods studyMiddle-income countriesMale partnersChildbearing ageHealth literacyPatient empowermentWomen of reproductive ageAbandonment of patientsHealth programsPremature mortalitySide effects of contraceptivesDescriptive methodologyConsiderable stigmaIncreased risk of cardiovascular complicationsQualitative studyRisk of cardiovascular complicationsLMICsCost-effectiveness of Canakinumab for Prevention of Recurrent Cardiovascular Events
Sehested T, Bjerre J, Ku S, Chang A, Jahansouz A, Owens D, Hlatky M, Goldhaber-Fiebert J. Cost-effectiveness of Canakinumab for Prevention of Recurrent Cardiovascular Events. JAMA Cardiology 2019, 4: 128-135. PMID: 30649147, PMCID: PMC6439626, DOI: 10.1001/jamacardio.2018.4566.Peer-Reviewed Original ResearchConceptsQuality-adjusted life yearsCost-effectiveness ratioIncremental cost-effectiveness ratioRecurrent cardiovascular eventsHealth-related quality of lifeStandard of careCanakinumab Anti-inflammatory Thrombosis Outcomes StudyHs-CRP levelsLung cancer incidenceHealth-related qualityMyocardial infarctionCardiovascular eventsRate of recurrent MIHealth care sector perspectiveReduced all-cause mortalityQuality of lifeAll-cause mortalityCost-effectiveUS health care sector perspectiveHs-CRPCancer incidenceRisk of recurrent cardiovascular eventsMain OutcomesHigh-sensitivity C-reactive proteinSubstantial price reductions
2021
Preoperative Computed Tomography Angiography Reveals Leaflet-Specific Calcification and Excursion Patterns in Aortic Stenosis
Chen I, Vedula V, Malik S, Liang T, Chang A, Chung K, Sayed N, Tsao P, Giacomini J, Marsden A, Wu J. Preoperative Computed Tomography Angiography Reveals Leaflet-Specific Calcification and Excursion Patterns in Aortic Stenosis. Circulation Cardiovascular Imaging 2021, 14: 1122-1132. PMID: 34915729, PMCID: PMC9206593, DOI: 10.1161/circimaging.121.012884.Peer-Reviewed Original ResearchConceptsAortic valve areaAortic stenosisNoncoronary cuspMale patientsCalcium scoreCoronary cuspValve areaNormal valvesEvaluation of aortic stenosisTranscatheter aortic valve replacementAortic valve replacementComputed tomography angiogramRight coronary cuspLeft coronary cuspNormal aortic valveRight coronary arteryAS severityValve replacementLeaflet thickeningOstial occlusionCalcification loadAortic valveLeaflet excursionCoronary arteryPatients
2020
Breast cancer induces systemic immune changes on cytokine signaling in peripheral blood monocytes and lymphocytes
Wang L, Simons D, Lu X, Tu T, Avalos C, Chang A, Dirbas F, Yim J, Waisman J, Lee P. Breast cancer induces systemic immune changes on cytokine signaling in peripheral blood monocytes and lymphocytes. EBioMedicine 2020, 52: 102631. PMID: 31981982, PMCID: PMC6992943, DOI: 10.1016/j.ebiom.2020.102631.Peer-Reviewed Original ResearchConceptsSystemic immune changesPeripheral blood monocytesBreast Cancer Research FoundationBreast Cancer Research ProgramBC patientsImmune changesBlood monocytesPeripheral bloodImmune cellsNon-metastatic BC patientsPeripheral blood immune cellsPeripheral blood T cellsCancer patients' peripheral bloodBlood immune cellsBreast cancer patientsOverall immune statusBlood T cellsPatients' peripheral bloodTumor-infiltrating macrophagesDefense Breast Cancer Research ProgramCancer Research ProgramCancer Research FoundationConcurrent cytokineLocalized diseaseImmune status
2018
Patient and facility variation in costs of catheter ablation for atrial fibrillation
Perino A, Fan J, Schmitt S, Kaiser D, Heidenreich P, Narayan S, Wang P, Chang A, Turakhia M. Patient and facility variation in costs of catheter ablation for atrial fibrillation. Journal Of Cardiovascular Electrophysiology 2018, 29: 1081-1088. PMID: 29864193, PMCID: PMC6469652, DOI: 10.1111/jce.13655.Peer-Reviewed Original Research
2017
IL6 Signaling in Peripheral Blood T Cells Predicts Clinical Outcome in Breast Cancer
Wang L, Miyahira A, Simons D, Lu X, Chang A, Wang C, Suni M, Maino V, Dirbas F, Yim J, Waisman J, Lee P. IL6 Signaling in Peripheral Blood T Cells Predicts Clinical Outcome in Breast Cancer. Cancer Research 2017, 77: 1119-1126. PMID: 27879265, PMCID: PMC5334262, DOI: 10.1158/0008-5472.can-16-1373.Peer-Reviewed Original ResearchConceptsPeripheral blood T cellsBreast cancer patientsBlood T cellsCancer patientsT cellsIL6 levelsWorse relapse-free survivalPlasma IL6 levelsCancer cellsRelapse-free survivalSerum IL6 levelsAnti-inflammatory propertiesHost immune responseInvolved downregulationClinical outcomesPredictive biomarkersImmune responsePleiotropic cytokinePatientsIL6Cancer ResCancer progressionSurvivalDiagnosisCells
2013
Spatial organization of dendritic cells within tumor draining lymph nodes impacts clinical outcome in breast cancer patients
Chang A, Bhattacharya N, Mu J, Setiadi A, Carcamo-Cavazos V, Lee G, Simons D, Yadegarynia S, Hemati K, Kapelner A, Ming Z, Krag D, Schwartz E, Chen D, Lee P. Spatial organization of dendritic cells within tumor draining lymph nodes impacts clinical outcome in breast cancer patients. Journal Of Translational Medicine 2013, 11: 242. PMID: 24088396, PMCID: PMC3852260, DOI: 10.1186/1479-5876-11-242.Peer-Reviewed Original ResearchConceptsBreast cancer patientsLymph nodesCancer patientsImmune cellsT cellsDendritic cellsIntra-mammary lymph nodesAnti-tumor immune responseDC cancer vaccinesKaplan-Maier analysisDisease-free survivalLog-rank testClinical outcome analysisT cell interactionsIntra-group comparisonInter-group comparisonMann-Whitney testDC clustersBackgroundDendritic cellsDC clusteringClinical outcomesCancer vaccinesSurvival outcomesDC functionNon-parametric Mann-Whitney test