2021
Commentary: Treatment-resistant Depression: Considerations Related to ECT and Ketamine
Garakani A. Commentary: Treatment-resistant Depression: Considerations Related to ECT and Ketamine. Journal Of Psychiatric Practice 2021, 27: 496-497. PMID: 34768276, DOI: 10.1097/pra.0000000000000593.Commentaries, Editorials and LettersConceptsTreatment-resistant depressionElectroconvulsive therapyLiver transplantationChronic treatment-resistant depressionUse of ECTMaintenance electroconvulsive therapyMajor depressive episodeBitemporal treatmentsIntranasal formsIntranasal ketaminePartial responsePrescribed antipsychoticsAdjunctive treatmentAntirejection medicationsChronic migraineMigraine medicationsECT treatmentComorbid migraineDepressive episodePsychotic featuresOrgan transplantationKetamine abuseBrain stimulationClinical considerationsPatientsSelective Serotonin Reuptake Inhibitors: How Long Is Long Enough?
Thom RP, Alexander JL, Baron D, Garakani A, Gross L, Pine JH, Radhakrishnan R, Slaby A, Sumner CR. Selective Serotonin Reuptake Inhibitors: How Long Is Long Enough? Journal Of Psychiatric Practice 2021, 27: 361-371. PMID: 34529602, DOI: 10.1097/pra.0000000000000578.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsSelective serotonin reuptake inhibitorsLong-term SSRI useSSRI useEase of titrationFirst-line medicationSerotonin reuptake inhibitorsRisk-benefit ratioMajor depressive disorderGeneral health risksShort-term useClinical practice considerationsDiscontinuation syndromeReuptake inhibitorsSafety profileDepressive disorderPatientsPsychiatric conditionsRelapse preventionMedicationsPossible adverse consequencesSpecial populationsAnxiety disordersTolerabilityPrescribersAdverse consequencesCommentary: Psychiatric Presentations of Nonpsychiatric Illness or Treatment
Garakani A. Commentary: Psychiatric Presentations of Nonpsychiatric Illness or Treatment. Journal Of Psychiatric Practice 2021, 27: 404-405. PMID: 34529609, DOI: 10.1097/pra.0000000000000577.Commentaries, Editorials and LettersConceptsManic symptomsPsychiatric historyPerinatal brain injuryOff-label useExamples of patientsPsychogenic nauseaRefractory nauseaGastroesophageal refluxAtypical presentationMood stabilizersSubdural hematomaCertain patientsMedical historyPsychiatric presentationsBrain injuryVisual hallucinationsMedical disordersPsychiatric symptomsPatientsNonpsychiatric illnessCognitive deficitsSuicidal thinkingSymptomsTraditional treatmentBrain imagingNeurological manifestations as the predictors of severity and mortality in hospitalized individuals with COVID-19: a multicenter prospective clinical study
Amanat M, Rezaei N, Roozbeh M, Shojaei M, Tafakhori A, Zoghi A, Darazam IA, Salehi M, Karimialavijeh E, Lima BS, Garakani A, Vaccaro A, Ramezani M. Neurological manifestations as the predictors of severity and mortality in hospitalized individuals with COVID-19: a multicenter prospective clinical study. BMC Neurology 2021, 21: 116. PMID: 33726699, PMCID: PMC7960879, DOI: 10.1186/s12883-021-02152-5.Peer-Reviewed Original ResearchConceptsShortness of breathPredictors of severityTaste dysfunctionNeurological manifestationsNeurological symptomsSevere casesCOVID-19Multicenter prospective clinical studyMulti-center prospective studyHyposmia/anosmiaGuillain-Barré syndromeWeeks of dischargeProspective clinical studyCommon neurological symptomsTime of admissionNon-neurological manifestationsCoronavirus disease 2019COVID-19 diseaseCerebrovascular eventsChest tightnessStatus epilepticusEligible casesNeurological findingsProspective studyMild headache
2019
Patient Requests for Discharge from Voluntary Psychiatric Hospitalization: a Chart Review
Garakani A, Appel JM, Aloysi AS, Martinez JM, Larkin K, Buono FD. Patient Requests for Discharge from Voluntary Psychiatric Hospitalization: a Chart Review. Psychiatric Quarterly 2019, 90: 849-859. PMID: 31468251, DOI: 10.1007/s11126-019-09671-y.Peer-Reviewed Original ResearchConceptsPsychiatric hospitalizationAdmission dayUrine toxicologyVoluntary Psychiatric HospitalizationSuicidal ideationNew York City hospitalsPositive urine toxicologyPrevious psychiatric hospitalizationInpatient psychiatric admissionStepwise linear regression analysisCalendar year 2007Chart reviewEarly dischargePsychiatric admissionsPatient outcomesInpatient careTobacco useCity HospitalPatient's requestInpatient servicesLinear regression analysisCigarette usePsychiatric inpatientsVoluntary admissionHospitalization
2013
Ophthalmologic Screening in 25 Consecutive Geriatric Psychiatric Inpatient Admissions
Billick SB, Garakani A. Ophthalmologic Screening in 25 Consecutive Geriatric Psychiatric Inpatient Admissions. Psychiatric Quarterly 2013, 85: 49-56. PMID: 23963654, DOI: 10.1007/s11126-013-9269-z.Peer-Reviewed Original ResearchConceptsOphthalmologic screeningAge-related macular degenerationGeriatric psychiatric patientsPsychiatric inpatient admissionsRisk of fallsGeneral physical examinationGeriatric psychiatric inpatientsInpatient psychiatric unitAccurate differential diagnosisQuality assurance reviewGeriatric patientsInpatient admissionsPhysical examinationMacular degenerationDifferential diagnosisVisual abnormalitiesChart documentationOphthalmic problemsPsychiatric unitPsychiatric patientsPsychiatric treatmentPatientsRetinal defectsPsychiatric inpatientsVisual problems
2012
Clinician-rated versus self-rated screening for bipolar disorder among inpatients with mood symptoms and substance misuse.
Goldberg JF, Garakani A, Ackerman SH. Clinician-rated versus self-rated screening for bipolar disorder among inpatients with mood symptoms and substance misuse. The Journal Of Clinical Psychiatry 2012, 73: 1525-30. PMID: 23290325, DOI: 10.4088/jcp.12m07926.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAlcoholismBipolar DisorderCross-Sectional StudiesDiagnosis, Dual (Psychiatry)Diagnostic Self EvaluationFemaleHospitalizationHumansInterview, PsychologicalMaleMass ScreeningMiddle AgedObserver VariationPsychometricsReproducibility of ResultsSubstance-Related DisordersYoung AdultConceptsMood Disorder QuestionnaireBipolar disorderSubstance misusePredictive valueHigh negative predictive valuePatient-clinician concordanceLow positive predictive valueDSM-IV-TR criteriaMood disorder patientsHigh prevalence ratesCross-sectional assessmentCurrent substance misuseSubstance use disordersNegative predictive valuePositive predictive valueSubstance use symptomsPsychiatrist's reviewClinician interviewsPositive statusMood disordersPrevalence ratesMood symptomsLifetime substanceUse disordersBipolar diagnosis
2010
Heart Rate and Blood Pressure Changes During Autonomic Nervous System Challenge in Panic Disorder Patients
Martinez JM, Garakani A, Kaufmann H, Aaronson CJ, Gorman JM. Heart Rate and Blood Pressure Changes During Autonomic Nervous System Challenge in Panic Disorder Patients. Psychosomatic Medicine 2010, 72: 442-449. PMID: 20368476, DOI: 10.1097/psy.0b013e3181d972c2.Peer-Reviewed Original ResearchConceptsLower heart rate variabilityMean diastolic blood pressureHigher heart rateHeart rate variabilityDiastolic blood pressureBlood pressureHealthy controlsHeart ratePanic disorder patientsPD patientsLF/HFOrthostatic challengeSympathovagal balanceDisorder patientsHigher mean diastolic blood pressureGreater cardiac riskIllness severity ratingsLess ill patientsSystolic blood pressureBlood pressure changesSeverity of illnessHigher low-frequency componentsAutonomic nervous systemIll patientsCardiac risk
2009
A Clinical Study of Competency to Consent to Hospitalization and Treatment in Geriatric Inpatients*
Billick SB, Perez DR, Garakani A. A Clinical Study of Competency to Consent to Hospitalization and Treatment in Geriatric Inpatients*. Journal Of Forensic Sciences 2009, 54: 943-946. PMID: 19486444, DOI: 10.1111/j.1556-4029.2009.01047.x.Peer-Reviewed Original ResearchConceptsMini-Mental State ExamBlessed Dementia ScaleGeriatric medicine unitMedical-surgical patientsMental State ExamSurgical patientsGeriatric patientsGeriatric inpatientsMedicine unitDementia ScaleClinical studiesClinical examUseful adjunctPatientsAge groupsFindings of competenceState ExamHospitalizationScoresWAIS-R subtestsTreatmentCompetency questionnaireExamInpatientsGreat variability
2008
Effect of medication and psychotherapy on heart rate variability in panic disorder
Garakani A, Martinez JM, Aaronson CJ, Voustianiouk A, Kaufmann H, Gorman JM. Effect of medication and psychotherapy on heart rate variability in panic disorder. Depression And Anxiety 2008, 26: 251-258. PMID: 18839407, DOI: 10.1002/da.20533.Peer-Reviewed Original ResearchConceptsHeart rate variabilityHeart rateRate variabilityLower heart rate variabilitySignificant clinical improvementWeeks of treatmentWeeks of CBTEffects of medicationPanic disorder patientsEffect of treatmentClinical improvementCardiac riskPD patientsCardiovascular diseaseTreatment respondersClinical measuresElevated riskDisorder patientsTreatment phasePatientsSymptom reductionPanic disorderHyperventilation challengeStatistical ManualSignificant decreaseA randomized, double-blind, and placebo-controlled trial of quetiapine augmentation of fluoxetine in major depressive disorder
Garakani A, Martinez JM, Marcus S, Weaver J, Rickels K, Fava M, Hirschowitz J. A randomized, double-blind, and placebo-controlled trial of quetiapine augmentation of fluoxetine in major depressive disorder. International Clinical Psychopharmacology 2008, 23: 269-275. PMID: 18703936, DOI: 10.1097/yic.0b013e328301a74c.Peer-Reviewed Original ResearchConceptsMontgomery-Asberg Depression Rating Scale scoreMajor depressive disorderDepression Rating Scale scoresHamilton Anxiety ScaleRating Scale scoresPlacebo groupDepressive disorderScale scoreCGI improvement scoreCombination of quetiapinePlacebo-controlled trialClinical global improvementWeeks of treatmentOnset of actionMixed effects linear regressionQuetiapine augmentationAnxiety ScaleFluoxetine groupFluoxetine treatmentCGI scoresImproved sleepMixed effects regressionInsomnia scoresQuetiapineFluoxetineShort-term tolerability of a nonazapirone selective serotonin 1A agonist in adults with generalized anxiety disorder: A 28-day, open-label study
Mathew SJ, Garakani A, Reinhard JF, Oshana S, Donahue S. Short-term tolerability of a nonazapirone selective serotonin 1A agonist in adults with generalized anxiety disorder: A 28-day, open-label study. Clinical Therapeutics 2008, 30: 1658-1666. PMID: 18840371, DOI: 10.1016/j.clinthera.2008.09.006.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAnti-Anxiety AgentsAnxiety DisordersDiagnostic and Statistical Manual of Mental DisordersDrug Administration ScheduleFemaleHumansMaleMiddle AgedPiperazinesPsychiatric Status Rating ScalesSerotonin 5-HT1 Receptor AgonistsSerotonin Receptor AgonistsSingle-Blind MethodSulfonamidesSurveys and QuestionnairesTreatment OutcomeConceptsGeneralized anxiety disorderShort-term tolerabilityAdverse eventsPRX-00023Hamilton Anxiety Rating Scale scoresVital signsResponse criteriaAnxiety disordersTotal scoreOpen-label studySerotonin 1A agonistSingle-blind placeboAnxiety Rating Scale scoresSerious adverse eventsStudy end pointInfluenza-like symptomsOpen-label treatmentPrimary outcome measureDiagnosis of GADRating Scale scoresEnd point changeSample of patientsSerotonin 1A receptorPremature ventricular contractionsSelective partial agonist