2020
Impact of depressive symptoms on self-perceived severity of autonomic dysfunction in multiple system atrophy: relevance for patient-reported outcomes in clinical trials
Martinez J, Palma JA, Norcliffe-Kaufmann L, Garakani A, Kaufmann H. Impact of depressive symptoms on self-perceived severity of autonomic dysfunction in multiple system atrophy: relevance for patient-reported outcomes in clinical trials. Clinical Autonomic Research 2020, 30: 215-221. PMID: 32246226, PMCID: PMC7341538, DOI: 10.1007/s10286-020-00681-6.Peer-Reviewed Original ResearchConceptsMultiple system atrophyOrthostatic Hypotension QuestionnaireSymptoms of depressionOrthostatic hypotensionAutonomic dysfunctionDepressive symptomsSelf-perceived severityAutonomic symptomsSystem atrophyDepression scoresOHQ scoresOrthostatic blood pressure fallUnified MSA Rating ScaleProbable multiple system atrophyComposite Autonomic Symptom ScoreBlood pressure fallResultsFifty-eight patientsSystolic blood pressureZung depression scorePatient-reported outcomesAutonomic symptom scoreClinical trial designMultivariable regression modelsQuality of lifeConclusionsIn patients
2010
Heart Rate and Blood Pressure Changes During Autonomic Nervous System Challenge in Panic Disorder Patients
Martinez JM, Garakani A, Kaufmann H, Aaronson CJ, Gorman JM. Heart Rate and Blood Pressure Changes During Autonomic Nervous System Challenge in Panic Disorder Patients. Psychosomatic Medicine 2010, 72: 442-449. PMID: 20368476, DOI: 10.1097/psy.0b013e3181d972c2.Peer-Reviewed Original ResearchConceptsLower heart rate variabilityMean diastolic blood pressureHigher heart rateHeart rate variabilityDiastolic blood pressureBlood pressureHealthy controlsHeart ratePanic disorder patientsPD patientsLF/HFOrthostatic challengeSympathovagal balanceDisorder patientsHigher mean diastolic blood pressureGreater cardiac riskIllness severity ratingsLess ill patientsSystolic blood pressureBlood pressure changesSeverity of illnessHigher low-frequency componentsAutonomic nervous systemIll patientsCardiac risk