2022
An umbrella review on the use of antipsychotics in anxiety disorders: A registered report protocol
Garakani A, Freire RC, Buono FD, Thom RP, Larkin K, Funaro MC, Salehi M, Perez-Rodriguez MM. An umbrella review on the use of antipsychotics in anxiety disorders: A registered report protocol. PLOS ONE 2022, 17: e0269772. PMID: 35709149, PMCID: PMC9202921, DOI: 10.1371/journal.pone.0269772.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsSelective serotonin reuptake inhibitorsSerotonin-norepinephrine reuptake inhibitorsUse of antipsychoticsLong-term riskAnxiety disordersReuptake inhibitorsUmbrella reviewSide effectsPanic disorderSystematic reviewNon-antipsychotic medicationsUse of quetiapineFirst-line treatmentSerotonin reuptake inhibitorsNorepinephrine reuptake inhibitorsEvidence of efficacyCommon psychiatric disordersTraditional pharmacologic treatmentTreatment of anxietyAdjunctive treatmentPharmacologic treatmentTricyclic antidepressantsAntipsychoticsPsychiatric disordersSocial anxiety disorder
2020
Pharmacotherapy of Anxiety Disorders: Current and Emerging Treatment Options
Garakani A, Murrough JW, Freire RC, Thom RP, Larkin K, Buono FD, Iosifescu DV. Pharmacotherapy of Anxiety Disorders: Current and Emerging Treatment Options. Frontiers In Psychiatry 2020, 11: 595584. PMID: 33424664, PMCID: PMC7786299, DOI: 10.3389/fpsyt.2020.595584.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsSerotonin-norepinephrine reuptake inhibitorsSelective serotonin reuptake inhibitorsPosttraumatic stress disorderAnxiety disordersGABAergic medicationsReuptake inhibitorsRandomized double-blind placebo-controlled trialDouble-blind placebo-controlled trialPanic disorderStress disorderSpecific phobiaBeta-adrenergic medicationsPlacebo-controlled trialCurrent pharmacological treatmentsNorepinephrine reuptake inhibitorsSerotonin reuptake inhibitorsCause of disabilityPrevalent psychiatric disordersNovel pharmacotherapeutic agentsBeta-adrenergic agentsSocial anxiety disorderMixed antidepressantsGlutamate modulatorsGlutamatergic agentsObsessive-compulsive disorder
2015
Heart rate and respiratory response to doxapram in patients with panic disorder
Martinez JM, Garakani A, Aaronson CJ, Gorman JM. Heart rate and respiratory response to doxapram in patients with panic disorder. Psychiatry Research 2015, 227: 32-38. PMID: 25819170, PMCID: PMC4420657, DOI: 10.1016/j.psychres.2015.03.001.Peer-Reviewed Original ResearchConceptsPD patientsLF/HFPanic disorderHealthy controlsAnticipatory anxietyPD subjectsParasympathetic componentRespiratory responsesLF/HF ratioSensation of dyspneaHeart rate variability indicesHigher sympathetic activityInjection of salinePanic statesSympathetic activityRespiratory abnormalitiesBrain stemRespiratory stimulantHeart rateParasympathetic responsePanic attacksPatientsExaggerated fear responsePanic symptomsHF ratio
2008
Effect of medication and psychotherapy on heart rate variability in panic disorder
Garakani A, Martinez JM, Aaronson CJ, Voustianiouk A, Kaufmann H, Gorman JM. Effect of medication and psychotherapy on heart rate variability in panic disorder. Depression And Anxiety 2008, 26: 251-258. PMID: 18839407, DOI: 10.1002/da.20533.Peer-Reviewed Original ResearchConceptsHeart rate variabilityHeart rateRate variabilityLower heart rate variabilitySignificant clinical improvementWeeks of treatmentWeeks of CBTEffects of medicationPanic disorder patientsEffect of treatmentClinical improvementCardiac riskPD patientsCardiovascular diseaseTreatment respondersClinical measuresElevated riskDisorder patientsTreatment phasePatientsSymptom reductionPanic disorderHyperventilation challengeStatistical ManualSignificant decrease
2007
The effect of doxapram on brain imaging in patients with panic disorder
Garakani A, Buchsbaum MS, Newmark RE, Goodman C, Aaronson CJ, Martinez JM, Torosjan Y, Chu KW, Gorman JM. The effect of doxapram on brain imaging in patients with panic disorder. European Neuropsychopharmacology 2007, 17: 672-686. PMID: 17560768, PMCID: PMC2695988, DOI: 10.1016/j.euroneuro.2007.04.002.Peer-Reviewed Original ResearchConceptsPanic disorder patientsDisorder patientsPlacebo saline solutionEffects of doxapramNormal control subjectsHeart rate increasePositron emission tomographyGreater heart rate increasePlacebo dayControl subjectsRespiratory stimulantCingulate gyrusDoxapramNormal volunteersPatientsPanic patientsPanic attacksPanic disorderDoxapram hydrochlorideSeparate daysEmission tomographyInhibitory centersFunctional imagingAmygdala activityCounterbalanced order
2006
Neurobiology of anxiety disorders and implications for treatment.
Garakani A, Mathew SJ, Charney DS. Neurobiology of anxiety disorders and implications for treatment. Annals Of Global Health 2006, 73: 941-9. PMID: 17195879.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsPost-traumatic stress disorderCognitive behavioral therapyFear conditioningUnconditioned stimulusAnxiety disordersPartial NMDA agonistFear inhibitionFear extinctionTraumatic memoriesFear circuitryFear responsesPavlovian conditioningBehavioral therapyStress disorderSpecific phobiaNew learningAmygdala pathwayD-cycloserineAnti-anxiety treatmentPanic disorderPreliminary evidenceStimuliMemoryN-methyl-D-aspartate antagonistsNeurobiology
2003
Comorbidity of Irritable Bowel Syndrome in Psychiatric Patients: A Review
Garakani A, Win T, Virk S, Gupta S, Kaplan D, Masand PS. Comorbidity of Irritable Bowel Syndrome in Psychiatric Patients: A Review. American Journal Of Therapeutics 2003, 10: 61-67. PMID: 12522523, DOI: 10.1097/00045391-200301000-00014.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsIrritable bowel syndromePsychiatric patientsBowel syndromeChronic abdominal discomfortFunctional gastrointestinal disordersU.S. adult populationStool frequencyAbdominal bloatingAbdominal discomfortPresence of mucusGastrointestinal disordersPsychiatric comorbidityMajor depressionHigh prevalencePanic disorderPatientsAdult populationComorbiditiesAnxiety disordersSyndromeDisordersPrevalenceTreatmentRecent studiesBloating