Prediction of outcomes after acute kidney injury in hospitalised patients: protocol for a systematic review
Arora T, Martin M, Grimshaw A, Mansour S, Wilson FP. Prediction of outcomes after acute kidney injury in hospitalised patients: protocol for a systematic review. BMJ Open 2020, 10: e042035. PMID: 33371041, PMCID: PMC7757434, DOI: 10.1136/bmjopen-2020-042035.Peer-Reviewed Original ResearchConceptsAcute kidney injuryPrediction of outcomeSystematic reviewKidney injuryOutcomes of AKIResolution of AKIProgression of AKILong-term outcomesBias assessment toolRisk of biasMultivariable predictive modelMeta-Analyses (PRISMA) guidelinesPreferred Reporting ItemsFull-text reviewPrediction model RiskAKI careCohort studyNegative long-term outcomesThird reviewerReporting ItemsAbstract screeningComprehensive searchPatientsCommon diseaseData extractionEvaluation of Daratumumab for the Treatment of Multiple Myeloma in Patients With High-risk Cytogenetic Factors
Giri S, Grimshaw A, Bal S, Godby K, Kharel P, Djulbegovic B, Dimopoulos MA, Facon T, Usmani SZ, Mateos MV, Costa LJ. Evaluation of Daratumumab for the Treatment of Multiple Myeloma in Patients With High-risk Cytogenetic Factors. JAMA Oncology 2020, 6: 1759-1765. PMID: 32970151, PMCID: PMC7516804, DOI: 10.1001/jamaoncol.2020.4338.Peer-Reviewed Original ResearchConceptsProgression-free survivalHigh-risk MMBackbone regimensRefractory MMHazard ratioMultiple myelomaClinical trialsSystematic reviewDerSimonian-Laird random-effects modelPhase 3 trialImproved response ratesPreferred Reporting ItemsRandom-effects modelCochrane riskSame regimenCytogenetic riskCochrane LibraryMeeting libraryI2 statisticImproved outcomesMAIN OUTCOMEThird investigatorCochran's QPatientsReporting Items