1999
A Human Anti-HIV Autoantibody Enhances EBV Transformation and HIV Infection
Cavacini L, Wisnewski A, Peterson J, Montefiori D, Emes C, Duval M, Kingsbury G, Wang A, Scadden D, Posner M. A Human Anti-HIV Autoantibody Enhances EBV Transformation and HIV Infection. Clinical Immunology 1999, 93: 263-273. PMID: 10600338, DOI: 10.1006/clim.1999.4790.Peer-Reviewed Original ResearchConceptsUninfected lymphoid cellsLymphoid cellsEBV transformationB cellsHIV-1-infected cellsHIV-1 infectionComplement-dependent mannerCross-reactive natureB cell proliferationNormal B cellsHIV infectionHIV pathogenesisNK cellsAntibody responseFree gp120Immunoglobulin productionT cellsHIV-1Human mAbsViral infectionVH3 family genesIgG mAbsHuman IgG mAbsUninfected cellsInfection
1998
Phase I Study of a Human Monoclonal Antibody Directed against the CD4-Binding Site of HIV Type 1 Glycoprotein 120
Cavacini LA, Samore MH, Gambertoglio J, Jackson B, Duval M, Wisnewski A, Hammer S, Koziel C, Trapnell C, Posner MR. Phase I Study of a Human Monoclonal Antibody Directed against the CD4-Binding Site of HIV Type 1 Glycoprotein 120. AIDS Research And Human Retroviruses 1998, 14: 545-550. PMID: 9591708, DOI: 10.1089/aid.1998.14.545.Peer-Reviewed Original ResearchConceptsSingle doseHIV Type 1 Glycoprotein 120HIV-1-infected individualsHIV-1-infected cellsAnti-HIV-1 activityFunctional activityCD4-binding siteCD4 binding siteHuman monoclonal antibodyAbility of serumInfused antibodyQuantitative microcultureAntibody infusionEscalation studyFull functional activityGlycoprotein 120Primary isolatesHIV-1Immune responseSingle injectionGp120-CD4PatientsSite antibodiesCD4Spectrum of isolates
1996
Human antibody variable region gene usage in HIV-1 infection.
Wisnewski A, Cavacini L, Posner M. Human antibody variable region gene usage in HIV-1 infection. JAIDS Journal Of Acquired Immune Deficiency Syndromes 1996, 11: 31-8. PMID: 8528730, DOI: 10.1097/00042560-199601010-00004.Peer-Reviewed Original ResearchConceptsHIV-1 infectionHIV-1 pathogenesisVariable region gene usageRegion gene usageGene usageHuman immunodeficiency virus type 1 (HIV-1) infectionHIV-1-infected patientsVirus type 1 infectionHuman humoral immune responseAnti-HIV-1 antibodiesDifferent lymphoid compartmentsType 1 infectionHumoral immune responsePeripheral blood lymphocytesPolymerase chain reaction studiesHuman monoclonal antibodyAIDS patientsInfected patientsBlood lymphocytesLymphoid compartmentsGene expressionHIV-1Immune responseSerum IgSerological studies