2017
Single-Cell Metabolomics by Mass Spectrometry for Drug Discovery: Moving Forward
K R, T W, SF N, AV W. Single-Cell Metabolomics by Mass Spectrometry for Drug Discovery: Moving Forward. Drug Designing Open Access 2017, 6: 1-5. DOI: 10.4172/2169-0138.1000149.Peer-Reviewed Original ResearchSingle-cell metabolomicsMolecular levelSingle-cell isolationCellular functionsCellular statesOmics approachesFunctional screenMetabolite poolsCell metabolomicsCellular interactionsBiological researchMass spectrometryCell sortingDrug discoveryMetabolomicsTandem mass spectrometryDrug developmentMetabolomics researchConcentrations of metabolitesEnvironmental influencesComprehensive understandingComprehensive informationSortingFuture prospectsCells
2015
Impact of recent innovations in the use of mass cytometry in support of drug development
Nassar AF, Ogura H, Wisnewski AV. Impact of recent innovations in the use of mass cytometry in support of drug development. Drug Discovery Today 2015, 20: 1169-1175. PMID: 26092491, PMCID: PMC4668584, DOI: 10.1016/j.drudis.2015.06.001.Peer-Reviewed Original ResearchConceptsSingle-cell technologiesSingle-cell levelDrug developmentSingle cellsDiseased statesCell levelMechanism of actionMass cytometryCellsDrug profilingIndividual biological cellsCyTOFImportant roleSignal overlapCytometryIndividual samplesBiological cellsProfilingSignificant advancesCell technology