2023
Uterine Collagen Cross-Linking: Biology, Role in Disorders, and Therapeutic Implications
Kurt I, Kulhan M, AlAshqar A, Borahay M. Uterine Collagen Cross-Linking: Biology, Role in Disorders, and Therapeutic Implications. Reproductive Sciences 2023, 31: 645-660. PMID: 37907804, DOI: 10.1007/s43032-023-01386-7.Peer-Reviewed Original ResearchPreterm birthUterine fibroidsLysyl oxidaseWarrants further investigationUterine extracellular matrixCervical insufficiencyHealthy pregnancyUterine disordersUterine tissueAdvanced glycationTherapeutic implicationsTherapeutic targetPathogenic featuresSteroid hormonesNitric oxideBiomechanical strengthUterine collagenNormal biophysical propertiesFibroidsFurther investigationPentosidinePyridinolineDisordersBirthTissue integrityOxidative Stress and Antioxidants in Uterine Fibroids: Pathophysiology and Clinical Implications
AlAshqar A, Lulseged B, Mason-Otey A, Liang J, Begum U, Afrin S, Borahay M. Oxidative Stress and Antioxidants in Uterine Fibroids: Pathophysiology and Clinical Implications. Antioxidants 2023, 12: 807. PMID: 37107181, PMCID: PMC10135366, DOI: 10.3390/antiox12040807.Peer-Reviewed Original ResearchUterine fibroidsClinical implicationsOxidative stressFibroid developmentUterine fibroid developmentProfibrotic mechanismsBody of evidenceDietary factorsNeoplastic entitiesComplex pathobiologyCurrent evidenceFibroidsPathobiologyPharmaceutical antioxidantsAntioxidantsPathophysiologyTumorsDiagnosisHypoxiaBiomarkers
2021
Vascular biology of uterine fibroids: connecting fibroids and vascular disorders.
Kirschen GW, AlAshqar A, Miyashita-Ishiwata M, Reschke L, El Sabeh M, Borahay MA. Vascular biology of uterine fibroids: connecting fibroids and vascular disorders. Reproduction 2021, 162: r1-r18. PMID: 34034234, PMCID: PMC8320308, DOI: 10.1530/rep-21-0087.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsVascular disordersMyometrial smooth muscle cellsSystemic vascular disorderSmooth muscle cellsAbdominal painAldosterone systemUrinary retentionEndothelial dysfunctionEssential hypertensionUterine fibroidsBenign tumorsFibroid growthDisease processFibroidsNovel treatmentsFibroid pathogenesisMuscle cellsCell-intrinsic factorsVascular biologyPharmaceutical agentsUterusVasculature systemDisordersConstipationHypertension