2023
Uterine Collagen Cross-Linking: Biology, Role in Disorders, and Therapeutic Implications
Kurt I, Kulhan M, AlAshqar A, Borahay M. Uterine Collagen Cross-Linking: Biology, Role in Disorders, and Therapeutic Implications. Reproductive Sciences 2023, 31: 645-660. PMID: 37907804, DOI: 10.1007/s43032-023-01386-7.Peer-Reviewed Original ResearchPreterm birthUterine fibroidsLysyl oxidaseWarrants further investigationUterine extracellular matrixCervical insufficiencyHealthy pregnancyUterine disordersUterine tissueAdvanced glycationTherapeutic implicationsTherapeutic targetPathogenic featuresSteroid hormonesNitric oxideBiomechanical strengthUterine collagenNormal biophysical propertiesFibroidsFurther investigationPentosidinePyridinolineDisordersBirthTissue integrity
2021
Vascular biology of uterine fibroids: connecting fibroids and vascular disorders.
Kirschen GW, AlAshqar A, Miyashita-Ishiwata M, Reschke L, El Sabeh M, Borahay MA. Vascular biology of uterine fibroids: connecting fibroids and vascular disorders. Reproduction 2021, 162: r1-r18. PMID: 34034234, PMCID: PMC8320308, DOI: 10.1530/rep-21-0087.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsVascular disordersMyometrial smooth muscle cellsSystemic vascular disorderSmooth muscle cellsAbdominal painAldosterone systemUrinary retentionEndothelial dysfunctionEssential hypertensionUterine fibroidsBenign tumorsFibroid growthDisease processFibroidsNovel treatmentsFibroid pathogenesisMuscle cellsCell-intrinsic factorsVascular biologyPharmaceutical agentsUterusVasculature systemDisordersConstipationHypertensionDiet and Nutrition in Gynecological Disorders: A Focus on Clinical Studies
Afrin S, AlAshqar A, Sabeh M, Miyashita-Ishiwata M, Reschke L, Brennan JT, Fader A, Borahay MA. Diet and Nutrition in Gynecological Disorders: A Focus on Clinical Studies. Nutrients 2021, 13: 1747. PMID: 34063835, PMCID: PMC8224039, DOI: 10.3390/nu13061747.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsGynecological disordersDietary habitsPolycystic ovary syndromeCurrent clinical dataPotential confounding factorsPlant-derived natural compoundsOvary syndromeGynecological malignanciesVitamin DGynecological diseasesClinical dataClinical studiesUterine leiomyomaPhysical activityMediterranean dietConfounding factorsEpidemiological investigationsHealthy lifestyleHomeostatic functionsRed meatBalanced dietNutritional factorsNutritional dataDietDisorders