Featured Publications
Protein-metabolite association studies identify novel proteomic determinants of metabolite levels in human plasma
Benson M, Eisman A, Tahir U, Katz D, Deng S, Ngo D, Robbins J, Hofmann A, Shi X, Zheng S, Keyes M, Yu Z, Gao Y, Farrell L, Shen D, Chen Z, Cruz D, Sims M, Correa A, Tracy R, Durda P, Taylor K, Liu Y, Johnson W, Guo X, Yao J, Chen Y, Manichaikul A, Jain D, Yang Q, Consortium N, Bouchard C, Sarzynski M, Rich S, Rotter J, Wang T, Wilson J, Clish C, Sarkar I, Natarajan P, Gerszten R. Protein-metabolite association studies identify novel proteomic determinants of metabolite levels in human plasma. Cell Metabolism 2023, 35: 1646-1660.e3. PMID: 37582364, PMCID: PMC11118091, DOI: 10.1016/j.cmet.2023.07.012.Peer-Reviewed Original ResearchConceptsAssociation studiesPlasma metabolomics studyKnockout strainGene-metabolitesProtein regulationHuman geneticsProteomic determinantsHuman plasmaMendelian randomizationSignaling pathwayThyroxine-binding globulinMetabolomics studiesMR associationsProteinBioactive proteinsMetabolite levelsHuman cohortsPlasma samplesUnrecognized associationCirculating proteinsHuman metabolismBiochemical profileMetabolitesAssociationPlasma
2007
Inhibition of Rho via Arg and p190RhoGAP in the Postnatal Mouse Hippocampus Regulates Dendritic Spine Maturation, Synapse and Dendrite Stability, and Behavior
Sfakianos MK, Eisman A, Gourley SL, Bradley WD, Scheetz AJ, Settleman J, Taylor JR, Greer CA, Williamson A, Koleske AJ. Inhibition of Rho via Arg and p190RhoGAP in the Postnatal Mouse Hippocampus Regulates Dendritic Spine Maturation, Synapse and Dendrite Stability, and Behavior. Journal Of Neuroscience 2007, 27: 10982-10992. PMID: 17928439, PMCID: PMC6672862, DOI: 10.1523/jneurosci.0793-07.2007.Peer-Reviewed Original ResearchConceptsDendritic spine maturationDendritic regressionSpine maturationDendritic spinesNormal morphological maturationDendritic spine lossPostnatal day 21Late postnatal developmentPostnatal mouse hippocampusDendrite stabilityPyramidal dendritesSpine lossSynaptic refinementProgressive deficitsHippocampal synapsesMature neuronsArbor developmentInhibitory pathwaysMouse hippocampusDendrite arborsDay 21Postnatal developmentMorphological maturationDendritic branchesDendrite morphogenesis