Featured Publications
Pulmonary Capillary Wedge Pressure Patterns During Exercise Predict Exercise Capacity and Incident Heart Failure
Eisman A, Shah R, Dhakal B, Pappagianopoulos P, Wooster L, Bailey C, Cunningham T, Hardin K, Baggish A, Ho J, Malhotra R, Lewis G. Pulmonary Capillary Wedge Pressure Patterns During Exercise Predict Exercise Capacity and Incident Heart Failure. Circulation Heart Failure 2018, 11: e004750. PMID: 29695381, PMCID: PMC5937988, DOI: 10.1161/circheartfailure.117.004750.Peer-Reviewed Original ResearchConceptsHeart failure outcomesExercise capacityCardiac outcomesHeart failureLeft ventricular ejection fractionLeft ventricular filling pressureMeasure of left ventricular filling pressureComposite cardiac outcomeDefinitions of HFpEFExercise hemodynamic measurementsPeak VO<sub>2</sub>Ventricular ejection fractionAdverse cardiac outcomesVentricular filling pressureFailure outcomesCardiopulmonary exercise testingBody mass indexPredicting exercise capacityIncident heart failureDifferentiate HFpEFNon-HFpEFEjection fractionHFpEF diagnosisMm HgFollow-up
2020
Exercise Pulmonary Hypertension Predicts Clinical Outcomes in Patients With Dyspnea on Effort
Ho J, Zern E, Lau E, Wooster L, Bailey C, Cunningham T, Eisman A, Hardin K, Farrell R, Sbarbaro J, Schoenike M, Houstis N, Baggish A, Shah R, Nayor M, Malhotra R, Lewis G. Exercise Pulmonary Hypertension Predicts Clinical Outcomes in Patients With Dyspnea on Effort. Journal Of The American College Of Cardiology 2020, 75: 17-26. PMID: 31918830, PMCID: PMC7043927, DOI: 10.1016/j.jacc.2019.10.048.Peer-Reviewed Original ResearchConceptsExercise pulmonary hypertensionPulmonary artery pressurePulmonary hypertensionAbnormal pulmonary artery pressureCardiac outputChronic exertional dyspneaEvent-free survivalInvasive hemodynamic monitoringPredicting clinical outcomesBurden of PHCV event-free survivalCardiopulmonary exercise testingPredicting adverse eventsTargeted therapeutic interventionsPH subtypesExertional dyspneaPrognostic implicationsClinical outcomesAdverse eventsResting pHResponse to exerciseDeath eventsFollow-upHemodynamic assessmentArterial pressure
2019
Differential Clinical Profiles, Exercise Responses, and Outcomes Associated With Existing HFpEF Definitions
Ho J, Zern E, Wooster L, Bailey C, Cunningham T, Eisman A, Hardin K, Zampierollo G, Jarolim P, Pappagianopoulos P, Malhotra R, Nayor M, Lewis G. Differential Clinical Profiles, Exercise Responses, and Outcomes Associated With Existing HFpEF Definitions. Circulation 2019, 140: 353-365. PMID: 31132875, PMCID: PMC6684250, DOI: 10.1161/circulationaha.118.039136.Peer-Reviewed Original ResearchConceptsHeart Failure Society of AmericaEuropean Society of CardiologyClinical profileHeart failureCardiovascular outcomesComprehensive cardiopulmonary exercise testingHemodynamic profile of patientsChronic exertional dyspneaDefinitions of HFpEFExercise responseSuspected heart failureAmerican College of Cardiology/American Heart AssociationInvasive hemodynamic monitoringPhenotype of patientsIncidence of cardiovascular outcomesCardiopulmonary exercise testingProfile of patientsClinical trial criteriaSociety of CardiologyPeak oxygen uptakeConsecutive patientsHFpEF subgroupsEjection fractionExertional dyspneaPrognostic implications
2018
Impaired right ventricular reserve predicts adverse cardiac outcomes in adults with congenital right heart disease
Yeh D, Schmidt A, Eisman A, Serfas J, Naqvi M, Youniss M, Ryfa A, Khan A, Safi L, Tabtabai S, Bhatt A, Lewis G. Impaired right ventricular reserve predicts adverse cardiac outcomes in adults with congenital right heart disease. Heart 2018, 104: 2044. PMID: 30030334, DOI: 10.1136/heartjnl-2017-312572.Peer-Reviewed Original ResearchConceptsCardiopulmonary exercise testingRV reserveRight ventricleHeart failureNew York Heart Association classPrimary composite clinical outcomeFirst-pass radionuclide ventriculographyPrevalence of heart failureRV ejection fractionRV systolic functionEvent-free survivalMedian follow-upCongenital heart diseaseReserve groupComposite clinical outcomeAdverse cardiac outcomesTertiary care centreRight ventricular reserveAdverse cardiovascular outcomesPredicting adverse cardiovascular outcomesSystolic function assessmentRV dilatationACHD populationPrognostic impactAsymptomatic patients
2016
Pulmonary Vascular Distensibility Predicts Pulmonary Hypertension Severity, Exercise Capacity, and Survival in Heart Failure
Malhotra R, Dhakal B, Eisman A, Pappagianopoulos P, Dress A, Weiner R, Baggish A, Semigran M, Lewis G. Pulmonary Vascular Distensibility Predicts Pulmonary Hypertension Severity, Exercise Capacity, and Survival in Heart Failure. Circulation Heart Failure 2016, 9: e003011. PMID: 27301469, PMCID: PMC4911900, DOI: 10.1161/circheartfailure.115.003011.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAntihypertensive AgentsArterial PressureCase-Control StudiesDouble-Blind MethodExercise TestExercise ToleranceFemaleHeart FailureHumansHypertension, PulmonaryKaplan-Meier EstimateLinear ModelsMaleMiddle AgedModels, CardiovascularMultivariate AnalysisPhosphodiesterase 5 InhibitorsPredictive Value of TestsProportional Hazards ModelsProspective StudiesPulmonary ArteryRisk AssessmentRisk FactorsSeverity of Illness IndexSildenafil CitrateStroke VolumeTime FactorsTreatment OutcomeVascular StiffnessVasodilator AgentsVentricular Function, RightConceptsPV distensibilityPulmonary arterial hypertensionReduced ejection fractionHeart failureEjection fractionExercise capacityArterial hypertensionHF patientsRight ventricular ejection fractionPulmonary artery wedge pressureReduced ejection fraction groupPulmonary arterial hypertension groupFirst-pass radionuclide ventriculographyPulmonary vasodilator therapyRV systolic functionVentricular ejection fractionLeft heart failurePulmonary artery pressureEjection fraction groupPulmonary hypertension severityRight ventricular performanceArterial hypertension groupInvasive hemodynamic monitoringWeeks of treatmentPredictors of peak VO2Association of Fitness in Young Adulthood With Survival and Cardiovascular Risk: The Coronary Artery Risk Development in Young Adults (CARDIA) Study
Shah R, Murthy V, Colangelo L, Reis J, Venkatesh B, Sharma R, Abbasi S, Goff D, Carr J, Rana J, Terry J, Bouchard C, Sarzynski M, Eisman A, Neilan T, Das S, Jerosch-Herold M, Lewis C, Carnethon M, Lewis G, Lima J. Association of Fitness in Young Adulthood With Survival and Cardiovascular Risk: The Coronary Artery Risk Development in Young Adults (CARDIA) Study. JAMA Internal Medicine 2016, 176: 1-9. PMID: 26618471, PMCID: PMC5292201, DOI: 10.1001/jamainternmed.2015.6309.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAsymptomatic DiseasesCardiovascular DiseasesCoronary Artery DiseaseExercise TestFemaleHeart VentriclesHumansHypertrophy, Left VentricularLongitudinal StudiesMaleMiddle AgedMortalityObesityPhysical FitnessProportional Hazards ModelsProspective StudiesTomography, X-Ray ComputedUltrasonographyUnited StatesVascular CalcificationYoung AdultConceptsCardiorespiratory fitnessIncident cardiovascular diseaseCoronary artery calcificationCardiovascular diseaseEffects of cardiorespiratory fitnessHazard of cardiovascular diseaseCoronary Artery Risk DevelopmentHigher level of fitnessImprove cardiorespiratory fitnessAssociation of fitnessBaseline cardiorespiratory fitnessExercise test durationAssessment of obesityAssociated with lower riskFollow-upLevel of fitnessTreadmill exercise testBaseline study visitCardiovascular disease eventsYoung adultsLeft ventricular massSubclinical cardiovascular diseasePresence of coronary artery calcificationYoung adulthoodAssociated with coronary artery calcification