2022
Whole Genome Association Study of the Plasma Metabolome Identifies Metabolites Linked to Cardiometabolic Disease in Black Individuals
Tahir U, Katz D, Avila-Pachecho J, Bick A, Pampana A, Robbins J, Yu Z, Chen Z, Benson M, Cruz D, Ngo D, Deng S, Shi X, Zheng S, Eisman A, Farrell L, Hall M, Correa A, Tracy R, Durda P, Taylor K, Liu Y, Johnson W, Guo X, Yao J, Chen Y, Manichaikul A, Ruberg F, Blaner W, Jain D, Bouchard C, Sarzynski M, Rich S, Rotter J, Wang T, Wilson J, Clish C, Natarajan P, Gerszten R. Whole Genome Association Study of the Plasma Metabolome Identifies Metabolites Linked to Cardiometabolic Disease in Black Individuals. Nature Communications 2022, 13: 4923. PMID: 35995766, PMCID: PMC9395431, DOI: 10.1038/s41467-022-32275-3.Peer-Reviewed Original ResearchMeSH KeywordsBlack PeopleCardiovascular DiseasesGenome-Wide Association StudyHumansMetabolomeMetabolomicsTandem Mass SpectrometryConceptsGenome association studiesGenomic diversityAssociation studiesWhole-genome association studiesLocus-metabolite associationsIndividuals of European ancestryIntegrative omics approachMetabolite peaksGenetic informationCardiometabolic diseasesSpecific allelesEuropean ancestryOmics approachesSickle cell diseaseMulti-ethnic cohortTransthyretin amyloidosisAncestryHereditary diseaseIdentified metabolitesCell diseaseHuman metabolismUnknown metabolitesDiversityBlack individualsJackson Heart Study
2016
Association of Fitness in Young Adulthood With Survival and Cardiovascular Risk: The Coronary Artery Risk Development in Young Adults (CARDIA) Study
Shah R, Murthy V, Colangelo L, Reis J, Venkatesh B, Sharma R, Abbasi S, Goff D, Carr J, Rana J, Terry J, Bouchard C, Sarzynski M, Eisman A, Neilan T, Das S, Jerosch-Herold M, Lewis C, Carnethon M, Lewis G, Lima J. Association of Fitness in Young Adulthood With Survival and Cardiovascular Risk: The Coronary Artery Risk Development in Young Adults (CARDIA) Study. JAMA Internal Medicine 2016, 176: 1-9. PMID: 26618471, PMCID: PMC5292201, DOI: 10.1001/jamainternmed.2015.6309.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAsymptomatic DiseasesCardiovascular DiseasesCoronary Artery DiseaseExercise TestFemaleHeart VentriclesHumansHypertrophy, Left VentricularLongitudinal StudiesMaleMiddle AgedMortalityObesityPhysical FitnessProportional Hazards ModelsProspective StudiesTomography, X-Ray ComputedUltrasonographyUnited StatesVascular CalcificationYoung AdultConceptsCardiorespiratory fitnessIncident cardiovascular diseaseCoronary artery calcificationCardiovascular diseaseEffects of cardiorespiratory fitnessHazard of cardiovascular diseaseCoronary Artery Risk DevelopmentHigher level of fitnessImprove cardiorespiratory fitnessAssociation of fitnessBaseline cardiorespiratory fitnessExercise test durationAssessment of obesityAssociated with lower riskFollow-upLevel of fitnessTreadmill exercise testBaseline study visitCardiovascular disease eventsYoung adultsLeft ventricular massSubclinical cardiovascular diseasePresence of coronary artery calcificationYoung adulthoodAssociated with coronary artery calcification