Protein-metabolite association studies identify novel proteomic determinants of metabolite levels in human plasma
Benson M, Eisman A, Tahir U, Katz D, Deng S, Ngo D, Robbins J, Hofmann A, Shi X, Zheng S, Keyes M, Yu Z, Gao Y, Farrell L, Shen D, Chen Z, Cruz D, Sims M, Correa A, Tracy R, Durda P, Taylor K, Liu Y, Johnson W, Guo X, Yao J, Chen Y, Manichaikul A, Jain D, Yang Q, Consortium N, Bouchard C, Sarzynski M, Rich S, Rotter J, Wang T, Wilson J, Clish C, Sarkar I, Natarajan P, Gerszten R. Protein-metabolite association studies identify novel proteomic determinants of metabolite levels in human plasma. Cell Metabolism 2023, 35: 1646-1660.e3. PMID: 37582364, PMCID: PMC11118091, DOI: 10.1016/j.cmet.2023.07.012.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsGenome-Wide Association StudyHumansMetabolomicsMicePolymorphism, Single NucleotideProteomicsSignal TransductionConceptsAssociation studiesPlasma metabolomics studyKnockout strainGene-metabolitesProtein regulationHuman geneticsProteomic determinantsHuman plasmaMendelian randomizationSignaling pathwayThyroxine-binding globulinMetabolomics studiesMR associationsProteinBioactive proteinsMetabolite levelsHuman cohortsPlasma samplesUnrecognized associationCirculating proteinsHuman metabolismBiochemical profileMetabolitesAssociationPlasma